E-ISSN 2534-9821
 

Original Research (Original Article) 


EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY

Eman Arif Rahman, Sri Vitayani Muchtar, Farida Tabri, Siswanto Wahab, Anni Adriani, Arifin Seweng, Rizalinda Sjahril.

Abstract
Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. In leprosy, cell-mediated immune responses are an important aspect of host resistance to mycobacterial infections and allegedly governed by anequilibrium between type 1 cytokines including Interleukin-12 (IL-12); with type 2 cytokines such as Interleukin-4 (IL-4). Currently, the World Health Organization (WHO) recommends 3 leprosy treatment regimens, one of them is Rifampicin Ofloxacin Minocycline (ROM). To date, studies on the effects of ROM on leprosy have been limited, none have specifically assessed the effects of ROM on specific immune systems, especially cytokines.
Methods: The study was conducted by prospective research method. The sample of this research were all multibacillary (MB) type of leprosy patients according to WHO classification who had received ROM therapy and recorded as the patient at research location and had medical record previous of interleukin-12 and interleukin-4 levels. After 12 months of ROM therapy, blood samples were collected and calculated using the Enzyme-Linked Immunosorbent Assay (ELISA) using the Quantikine® high sensitivity (HSv) kit.
Results: There was a statistically significant increase in IL-4 after 12 months of a 3-months-ROM therapy. In contrast, the levels of IL-12 after 12 months showed significant decreases.
Conclusions: Increased levels of IL-4 and decreased IL-12 can be caused by many factors. Therefore, further research with a closer supervision is required.

Key words: Leprosy, Rifampicin Ofloxacin Minocycline therapy, Interleukin-12, Interleukin-4


 
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Pubmed Style

Eman Arif Rahman, Sri Vitayani Muchtar, Farida Tabri, Siswanto Wahab, Anni Adriani, Arifin Seweng, Rizalinda Sjahril. EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY. Int J Med Rev Case Rep. 2018; 2(4): 161-165. doi:10.5455/IJMRCR.MULTIBACILLARY-TYPE-LEPROSY-INTERLEUKINS


Web Style

Eman Arif Rahman, Sri Vitayani Muchtar, Farida Tabri, Siswanto Wahab, Anni Adriani, Arifin Seweng, Rizalinda Sjahril. EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY. http://mdpub.net/?mno=297715 [Access: July 17, 2019]. doi:10.5455/IJMRCR.MULTIBACILLARY-TYPE-LEPROSY-INTERLEUKINS


AMA (American Medical Association) Style

Eman Arif Rahman, Sri Vitayani Muchtar, Farida Tabri, Siswanto Wahab, Anni Adriani, Arifin Seweng, Rizalinda Sjahril. EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY. Int J Med Rev Case Rep. 2018; 2(4): 161-165. doi:10.5455/IJMRCR.MULTIBACILLARY-TYPE-LEPROSY-INTERLEUKINS



Vancouver/ICMJE Style

Eman Arif Rahman, Sri Vitayani Muchtar, Farida Tabri, Siswanto Wahab, Anni Adriani, Arifin Seweng, Rizalinda Sjahril. EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY. Int J Med Rev Case Rep. (2018), [cited July 17, 2019]; 2(4): 161-165. doi:10.5455/IJMRCR.MULTIBACILLARY-TYPE-LEPROSY-INTERLEUKINS



Harvard Style

Eman Arif Rahman, Sri Vitayani Muchtar, Farida Tabri, Siswanto Wahab, Anni Adriani, Arifin Seweng, Rizalinda Sjahril (2018) EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY. Int J Med Rev Case Rep, 2 (4), 161-165. doi:10.5455/IJMRCR.MULTIBACILLARY-TYPE-LEPROSY-INTERLEUKINS



Turabian Style

Eman Arif Rahman, Sri Vitayani Muchtar, Farida Tabri, Siswanto Wahab, Anni Adriani, Arifin Seweng, Rizalinda Sjahril. 2018. EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY. International Journal of Medical Reviews and Case Reports, 2 (4), 161-165. doi:10.5455/IJMRCR.MULTIBACILLARY-TYPE-LEPROSY-INTERLEUKINS



Chicago Style

Eman Arif Rahman, Sri Vitayani Muchtar, Farida Tabri, Siswanto Wahab, Anni Adriani, Arifin Seweng, Rizalinda Sjahril. "EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY." International Journal of Medical Reviews and Case Reports 2 (2018), 161-165. doi:10.5455/IJMRCR.MULTIBACILLARY-TYPE-LEPROSY-INTERLEUKINS



MLA (The Modern Language Association) Style

Eman Arif Rahman, Sri Vitayani Muchtar, Farida Tabri, Siswanto Wahab, Anni Adriani, Arifin Seweng, Rizalinda Sjahril. "EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY." International Journal of Medical Reviews and Case Reports 2.4 (2018), 161-165. Print. doi:10.5455/IJMRCR.MULTIBACILLARY-TYPE-LEPROSY-INTERLEUKINS



APA (American Psychological Association) Style

Eman Arif Rahman, Sri Vitayani Muchtar, Farida Tabri, Siswanto Wahab, Anni Adriani, Arifin Seweng, Rizalinda Sjahril (2018) EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY. International Journal of Medical Reviews and Case Reports, 2 (4), 161-165. doi:10.5455/IJMRCR.MULTIBACILLARY-TYPE-LEPROSY-INTERLEUKINS