Abstract
Background: Hypokalemic periodic paralysis (hypokalemic PP) is the most common type of channelopathies that affect the muscular system. There is a lack of reports on the profile of patients with this neurological disorder in the Indonesian population. Methods: This was a retrospective descriptive study. Data were collected from medical records of patients admitted to the Sanglah General Hospital, Bali, Indonesia with hypokalemic periodic paralysis from January 2018 to March 2020. Results: A total of 17 patients with hypokalemic PP were admitted to the hospital during the period. The mean age was 35.6 years, range from 21 to 77 years. The majority of the patients were male (10, 58.8%). Six patients (35.3%) had a history of episodes of periodic paralysis. Almost all of the patients (94.12%) have no family history of periodic paralysis. Most of the patients (15, 88.23%) presented with tetraparesis, and only 2 (11.77%) presented with paraparesis. Four mortality was recorded during the period. The median initial serum K+ level was 1.69 mmol/L with a range from 0.93 mmol/L to 3.36 mmol/L. 4 patients (23.52%) with primary hypokalemic PP and 13 (76.48%) with secondary hypokalemic PP. The secondary causes of hypokalemic PP were gastrointestinal potassium loss (3 patients, 17.64%), Kidney loss (5 patients, 29.41%), thyroid disease (4 patients, 23.52%), and hyperinsulinemia (1 patient, 5.88%). Conclusion: A larger proportion of the presenting cases was secondary hypokalemic PP. Systematic examinations have to be done to figure out the exact cause of the hypokalemic to prevent further attacks and manage the underlying problem.

Key words: hypokalemic periodic paralysis, channelopathies, renal tubular acidosis, thyroid disease