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Online Publishing Date:
24 / 01 / 2022

 


Effectiveness of oral Ivabradine and oral Clonidine as pre medications on intraocular pressure changes following intubation with succinylcholine: A comparative study

Pragati Garg, Sanjay Chaubey, Mahrukh Khan, Asim Ahmad.


Abstract
Purpose: Endotracheal intubation with succinylcholine causes an undesirable rise in IOP. Clonidine, a selective alpha 2 agonist reduces IOP and provides better hemodynamic stability. Ivabradine, a sinus node inhibitor, shows attenuating effects for hemodynamics. The aim of this study is to compare the effectiveness of both these drugs as premeditates on IOP changes post-intubation with succinylcholine.
Methods: A hospital-based analytical comparative study was done on 105 patients in the age group 18-50 years scheduled for elective surgeries under general anaesthesia. The patients were randomly allocated into three groups of 35 each by computer-generated randomized tables. Group I was given oral ivabradine, Group II was given oral clonidine and Group III received a placebo 1 hour before intubation. IOP was measured just before premedication (T0), just before intubation (T1), just after induction of anaesthesia (T2), 2 minutes after intubation (T3), 5minutes after intubation (T4), 8minutes after intubation (T5), 10 minutes after intubation (T6). P<0.05 was taken as a significant value.
Results: The study findings showed that in comparison to ivabradine and placebo, clonidine was able to significantly decrease the IOP after intubation with succinylcholine (p<0.001). The range of IOP rise from baseline IOP to IOP following intubation with succinylcholine was very less with clonidine administration in comparison to ivabradine and the placebo group. Results were statistically significant at all periods of time when the IOP was measured after intubation (p<0.001).
Conclusion: Oral clonidine can effectively and safely be recommended as a premedicate for reducing the rise in IOP following endotracheal intubation with succinylcholine.

Key words: Intraocular Pressure (IOP), Clonidine, Ivabradine


 
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How to Cite this Article
Pubmed Style

Garg P, Chaubey S, Khan M, Ahmad A. Effectiveness of oral Ivabradine and oral Clonidine as pre medications on intraocular pressure changes following intubation with succinylcholine: A comparative study. Int J Med Rev Case Rep. 2022; 6(5): 38-41. doi:10.5455/IJMRCR.ivabradine-ocular

Web Style

Garg P, Chaubey S, Khan M, Ahmad A. Effectiveness of oral Ivabradine and oral Clonidine as pre medications on intraocular pressure changes following intubation with succinylcholine: A comparative study. https://www.mdpub.net/?mno=75099 [Access: April 04, 2024]. doi:10.5455/IJMRCR.ivabradine-ocular

AMA (American Medical Association) Style

Garg P, Chaubey S, Khan M, Ahmad A. Effectiveness of oral Ivabradine and oral Clonidine as pre medications on intraocular pressure changes following intubation with succinylcholine: A comparative study. Int J Med Rev Case Rep. 2022; 6(5): 38-41. doi:10.5455/IJMRCR.ivabradine-ocular


Vancouver/ICMJE Style

Garg P, Chaubey S, Khan M, Ahmad A. Effectiveness of oral Ivabradine and oral Clonidine as pre medications on intraocular pressure changes following intubation with succinylcholine: A comparative study. Int J Med Rev Case Rep. (2022), [cited April 04, 2024]; 6(5): 38-41. doi:10.5455/IJMRCR.ivabradine-ocular


Harvard Style

Garg, P., Chaubey, . S., Khan, . M. & Ahmad, . A. (2022) Effectiveness of oral Ivabradine and oral Clonidine as pre medications on intraocular pressure changes following intubation with succinylcholine: A comparative study. Int J Med Rev Case Rep, 6 (5), 38-41. doi:10.5455/IJMRCR.ivabradine-ocular


Turabian Style

Garg, Pragati, Sanjay Chaubey, Mahrukh Khan, and Asim Ahmad. 2022. Effectiveness of oral Ivabradine and oral Clonidine as pre medications on intraocular pressure changes following intubation with succinylcholine: A comparative study. International Journal of Medical Reviews and Case Reports, 6 (5), 38-41. doi:10.5455/IJMRCR.ivabradine-ocular


Chicago Style

Garg, Pragati, Sanjay Chaubey, Mahrukh Khan, and Asim Ahmad. "Effectiveness of oral Ivabradine and oral Clonidine as pre medications on intraocular pressure changes following intubation with succinylcholine: A comparative study." International Journal of Medical Reviews and Case Reports 6 (2022), 38-41. doi:10.5455/IJMRCR.ivabradine-ocular


MLA (The Modern Language Association) Style

Garg, Pragati, Sanjay Chaubey, Mahrukh Khan, and Asim Ahmad. "Effectiveness of oral Ivabradine and oral Clonidine as pre medications on intraocular pressure changes following intubation with succinylcholine: A comparative study." International Journal of Medical Reviews and Case Reports 6.5 (2022), 38-41. Print. doi:10.5455/IJMRCR.ivabradine-ocular


APA (American Psychological Association) Style

Garg, P., Chaubey, . S., Khan, . M. & Ahmad, . A. (2022) Effectiveness of oral Ivabradine and oral Clonidine as pre medications on intraocular pressure changes following intubation with succinylcholine: A comparative study. International Journal of Medical Reviews and Case Reports, 6 (5), 38-41. doi:10.5455/IJMRCR.ivabradine-ocular


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