E-ISSN 2534-9821
 

Case Report 


Motor and functional outcome of myelopathy following intrathecal chemotherapy

Pedro Ferreira, Teresa Silva, Anuraj Parmanande, Susana Rosa, Jaime Pamplona.

Abstract
Intrathecal (IT) chemotherapy is a widely used treatment for hematologic tumors with central nervous system involvement. We describe a 50-year-old patient with Burkitt type acute lymphocytic leukemia who developed a neurotoxic myelopathy after IT chemotherapy with methotrexate (MTX) and cytarabine (Ara-C). This type of adverse event is rare, is usually unresponsive to pharmacologic treatment and can be potentially devastating for the patient. Although rehabilitation was effective in restoring functional independence, only partial neurological recovery was achieved. Proper classification of spinal cord injury and outcome measures are essential to assess prognosis and treatment outcome in these patients.

Key words: myelopathy, intrathecal chemotherapy, functional independence


 
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How to Cite this Article
Pubmed Style

Ferreira P, Silva T, Parmanande A, Rosa S, Pamplona J. Motor and functional outcome of myelopathy following intrathecal chemotherapy. Int J Med Rev Case Rep. 2020; 4(12): 57-60. doi:10.5455/IJMRCR.Motor-functional-outcome-myelopathy


Web Style

Ferreira P, Silva T, Parmanande A, Rosa S, Pamplona J. Motor and functional outcome of myelopathy following intrathecal chemotherapy. http://www.mdpub.net/?mno=101252 [Access: January 10, 2021]. doi:10.5455/IJMRCR.Motor-functional-outcome-myelopathy


AMA (American Medical Association) Style

Ferreira P, Silva T, Parmanande A, Rosa S, Pamplona J. Motor and functional outcome of myelopathy following intrathecal chemotherapy. Int J Med Rev Case Rep. 2020; 4(12): 57-60. doi:10.5455/IJMRCR.Motor-functional-outcome-myelopathy



Vancouver/ICMJE Style

Ferreira P, Silva T, Parmanande A, Rosa S, Pamplona J. Motor and functional outcome of myelopathy following intrathecal chemotherapy. Int J Med Rev Case Rep. (2020), [cited January 10, 2021]; 4(12): 57-60. doi:10.5455/IJMRCR.Motor-functional-outcome-myelopathy



Harvard Style

Ferreira, P., Silva, . T., Parmanande, . A., Rosa, . S. & Pamplona, . J. (2020) Motor and functional outcome of myelopathy following intrathecal chemotherapy. Int J Med Rev Case Rep, 4 (12), 57-60. doi:10.5455/IJMRCR.Motor-functional-outcome-myelopathy



Turabian Style

Ferreira, Pedro, Teresa Silva, Anuraj Parmanande, Susana Rosa, and Jaime Pamplona. 2020. Motor and functional outcome of myelopathy following intrathecal chemotherapy. International Journal of Medical Reviews and Case Reports, 4 (12), 57-60. doi:10.5455/IJMRCR.Motor-functional-outcome-myelopathy



Chicago Style

Ferreira, Pedro, Teresa Silva, Anuraj Parmanande, Susana Rosa, and Jaime Pamplona. "Motor and functional outcome of myelopathy following intrathecal chemotherapy." International Journal of Medical Reviews and Case Reports 4 (2020), 57-60. doi:10.5455/IJMRCR.Motor-functional-outcome-myelopathy



MLA (The Modern Language Association) Style

Ferreira, Pedro, Teresa Silva, Anuraj Parmanande, Susana Rosa, and Jaime Pamplona. "Motor and functional outcome of myelopathy following intrathecal chemotherapy." International Journal of Medical Reviews and Case Reports 4.12 (2020), 57-60. Print. doi:10.5455/IJMRCR.Motor-functional-outcome-myelopathy



APA (American Psychological Association) Style

Ferreira, P., Silva, . T., Parmanande, . A., Rosa, . S. & Pamplona, . J. (2020) Motor and functional outcome of myelopathy following intrathecal chemotherapy. International Journal of Medical Reviews and Case Reports, 4 (12), 57-60. doi:10.5455/IJMRCR.Motor-functional-outcome-myelopathy