The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia

Agung Kurniawan; Ronald E. Lusikooy; Mappincara Mappincara; Murny A. Rauf; Ibrahim Labeda; Warsinggih Warsinggih; Samuel Sampetoding; M. Ihwan Kusuma; M. Iwan Dani; Ilham Jaya Patellongi; Muhammad Faruk

doi:10.5455/IJMRCR.colorectal-cancer-indonesia

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Original Research
Online Published: 27 Jun 2020

Int J Med Rev Case Rep. 2020; 4(6): 56-62

doi: 10.5455/IJMRCR.colorectal-cancer-indonesia

The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia

Agung Kurniawan, Ronald E. Lusikooy, Mappincara Mappincara, Murny A. Rauf, Ibrahim Labeda, Warsinggih Warsinggih, Samuel Sampetoding, M. Ihwan Kusuma, M. Iwan Dani, Ilham Jaya Patellongi, Muhammad Faruk.

Cited By: 2

Abstract
Introduction: Tumor markers combination (CEA, CA19-9, and CA125) can increase sensitivity due to interactions between several epitopes and tumor cells, especially in colorectal cancer (CRC) diagnosis. Therefore, this study aimed to assess the relationship between triple tumor markers (CEA, CA 19-9, CA 125) and CRC metastases.
Materials and Methods: The research samples were CRC patients at Dr. Wahidin Sudirohusodo Hospital, Makassar from November 2019 to April 2020. The histopathology data were collected through endoscopic or anal biopsy, CEA, CA 19-9, CA 125, Thorax X-Ray, Abdomen CT Scan, Surgery, and data processing. Furthermore, statistical tests were performed with the Mann Whitney difference test (significance = p <0.05).
Results: 57 samples were obtained, consisting of 19 metastatic CRC and 38 non-metastatic cases with an age range of 18-82 years, and an average of 56.9 years. Furthermore, most of the patients were males with a ratio of 2:1, and the tumors are mostly located in the rectum by 68.5%, of which many are in stage II with 52.6%. The CEA value was obtained at ≥ 10 ng/ml (61.4%) and <10 ng/ml (38.6%), CA 19-9 was ≥ 10 ng/ml (61.4%) and < 10 ng/ml (38.6%), and CA 125 was ≥ 10 ng/ml (61.4%) and < 10 ng/ml (38.6%). Also, most metastases are located in the liver. Triple tumor marker significantly correlated with CRC (p <0.05), and the accuracy of the three combinations increased (87.7%), which indicates the markers can establish the presence or absence of metastasis in CRC patients.
Conclusion: The markers (CEA, CA 19-9 and CA 125) can be used to establish the presence or absence of metastasis in CRC patients.

Key words: Tumor Markers, Metastasis, Colorectal Cancer, CEA

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How to Cite this Article

Pubmed Style

Kurniawan A, Lusikooy RE, Mappincara M, Rauf MA, Labeda I, Warsinggih W, Sampetoding S, Kusuma MI, Dani MI, Patellongi IJ, Faruk M. The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia. Int J Med Rev Case Rep. 2020; 4(6): 56-62. doi:10.5455/IJMRCR.colorectal-cancer-indonesia

Web Style

Kurniawan A, Lusikooy RE, Mappincara M, Rauf MA, Labeda I, Warsinggih W, Sampetoding S, Kusuma MI, Dani MI, Patellongi IJ, Faruk M. The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia. https://www.mdpub.net//?mno=105504 [Access: June 27, 2026]. doi:10.5455/IJMRCR.colorectal-cancer-indonesia

AMA (American Medical Association) Style

Kurniawan A, Lusikooy RE, Mappincara M, Rauf MA, Labeda I, Warsinggih W, Sampetoding S, Kusuma MI, Dani MI, Patellongi IJ, Faruk M. The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia. Int J Med Rev Case Rep. 2020; 4(6): 56-62. doi:10.5455/IJMRCR.colorectal-cancer-indonesia

Vancouver/ICMJE Style

Kurniawan A, Lusikooy RE, Mappincara M, Rauf MA, Labeda I, Warsinggih W, Sampetoding S, Kusuma MI, Dani MI, Patellongi IJ, Faruk M. The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia. Int J Med Rev Case Rep. (2020), [cited June 27, 2026]; 4(6): 56-62. doi:10.5455/IJMRCR.colorectal-cancer-indonesia

Harvard Style

Kurniawan, A., Lusikooy, . R. E., Mappincara, . M., Rauf, . M. A., Labeda, . I., Warsinggih, . W., Sampetoding, . S., Kusuma, . M. I., Dani, . M. I., Patellongi, . I. J. & Faruk, . M. (2020) The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia. Int J Med Rev Case Rep, 4 (6), 56-62. doi:10.5455/IJMRCR.colorectal-cancer-indonesia

Turabian Style

Kurniawan, Agung, Ronald E. Lusikooy, Mappincara Mappincara, Murny A. Rauf, Ibrahim Labeda, Warsinggih Warsinggih, Samuel Sampetoding, M. Ihwan Kusuma, M. Iwan Dani, Ilham Jaya Patellongi, and Muhammad Faruk. 2020. The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia. International Journal of Medical Reviews and Case Reports, 4 (6), 56-62. doi:10.5455/IJMRCR.colorectal-cancer-indonesia

Chicago Style

Kurniawan, Agung, Ronald E. Lusikooy, Mappincara Mappincara, Murny A. Rauf, Ibrahim Labeda, Warsinggih Warsinggih, Samuel Sampetoding, M. Ihwan Kusuma, M. Iwan Dani, Ilham Jaya Patellongi, and Muhammad Faruk. "The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia." International Journal of Medical Reviews and Case Reports 4 (2020), 56-62. doi:10.5455/IJMRCR.colorectal-cancer-indonesia

MLA (The Modern Language Association) Style

Kurniawan, Agung, Ronald E. Lusikooy, Mappincara Mappincara, Murny A. Rauf, Ibrahim Labeda, Warsinggih Warsinggih, Samuel Sampetoding, M. Ihwan Kusuma, M. Iwan Dani, Ilham Jaya Patellongi, and Muhammad Faruk. "The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia." International Journal of Medical Reviews and Case Reports 4.6 (2020), 56-62. Print. doi:10.5455/IJMRCR.colorectal-cancer-indonesia

APA (American Psychological Association) Style

Kurniawan, A., Lusikooy, . R. E., Mappincara, . M., Rauf, . M. A., Labeda, . I., Warsinggih, . W., Sampetoding, . S., Kusuma, . M. I., Dani, . M. I., Patellongi, . I. J. & Faruk, . M. (2020) The relationship between triple tumor marker (CEA, CA 19-9, AND CA 125) and colorectal cancer metastases at Makassar, Indonesia. International Journal of Medical Reviews and Case Reports, 4 (6), 56-62. doi:10.5455/IJMRCR.colorectal-cancer-indonesia

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