E-ISSN 2534-9821
 

Review Article 


A clinical approach of renal involvement in granulomatosis with polyangiitis

Stoian Marilena, Indrei Lucia, Stoica Viktor.

Abstract
Granulomatosis with polyangiitis (GPA, Wegener’s granulomatosis) is one of the antineutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis involving various organs such as nasal septum, sinuses, upper respiratory tract, lungs, and kidneys. GPA is pathologically characterized by necrotizing granulomatous inflammation ANCA-associated small vessel vasculitis represent a major challenge in hospital admissions; therefore, early and accurate diagnosis with aggressive treatment is essential to improve the disease outcome.
Renal involvement of Granulomatosis with Polyangiitis is characterized morphologically by extensive crescent formation (extracapillary proliferation in Bowman's space), and clinically by crescentic or rapidly progressive glomerulonephritis that causes hematuria, erythrocyte casts, and proteinuria with progressive loss of renal function.
The diagnosis of Granulomatosis with Polyangiitis is established most securely by biopsy specimens showing the triad of vasculitis, granulomata, and large areas of necrosis (known as geographic necrosis) admitted with acute and chronic inflammatory cells. Usually, renal involvement is severe and is the leading cause of mortality. The combination of high-dose corticosteroids and cyclophosphamide is the mainstay of treatment for vasculitis and disease resistance to this combination is rare.

Key words: Granulomatosis with Polyangiitis, vasculitis, crescentic glomerulonephritis, ANCA-small vessel vasculitis, Anti-GBM glomerulonephritis


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Stoian Marilena
Articles by Indrei Lucia
Articles by Stoica Viktor
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Marilena S, Lucia I, Viktor S. A clinical approach of renal involvement in granulomatosis with polyangiitis. Int J Med Rev Case Rep. 2020; 4(5): 116-119. doi:10.5455/IJMRCR.granulomatosis-polyangiitis


Web Style

Marilena S, Lucia I, Viktor S. A clinical approach of renal involvement in granulomatosis with polyangiitis. http://www.mdpub.net/?mno=106205 [Access: July 02, 2020]. doi:10.5455/IJMRCR.granulomatosis-polyangiitis


AMA (American Medical Association) Style

Marilena S, Lucia I, Viktor S. A clinical approach of renal involvement in granulomatosis with polyangiitis. Int J Med Rev Case Rep. 2020; 4(5): 116-119. doi:10.5455/IJMRCR.granulomatosis-polyangiitis



Vancouver/ICMJE Style

Marilena S, Lucia I, Viktor S. A clinical approach of renal involvement in granulomatosis with polyangiitis. Int J Med Rev Case Rep. (2020), [cited July 02, 2020]; 4(5): 116-119. doi:10.5455/IJMRCR.granulomatosis-polyangiitis



Harvard Style

Marilena, S., Lucia, . I. & Viktor, . S. (2020) A clinical approach of renal involvement in granulomatosis with polyangiitis. Int J Med Rev Case Rep, 4 (5), 116-119. doi:10.5455/IJMRCR.granulomatosis-polyangiitis



Turabian Style

Marilena, Stoian, Indrei Lucia, and Stoica Viktor. 2020. A clinical approach of renal involvement in granulomatosis with polyangiitis. International Journal of Medical Reviews and Case Reports, 4 (5), 116-119. doi:10.5455/IJMRCR.granulomatosis-polyangiitis



Chicago Style

Marilena, Stoian, Indrei Lucia, and Stoica Viktor. "A clinical approach of renal involvement in granulomatosis with polyangiitis." International Journal of Medical Reviews and Case Reports 4 (2020), 116-119. doi:10.5455/IJMRCR.granulomatosis-polyangiitis



MLA (The Modern Language Association) Style

Marilena, Stoian, Indrei Lucia, and Stoica Viktor. "A clinical approach of renal involvement in granulomatosis with polyangiitis." International Journal of Medical Reviews and Case Reports 4.5 (2020), 116-119. Print. doi:10.5455/IJMRCR.granulomatosis-polyangiitis



APA (American Psychological Association) Style

Marilena, S., Lucia, . I. & Viktor, . S. (2020) A clinical approach of renal involvement in granulomatosis with polyangiitis. International Journal of Medical Reviews and Case Reports, 4 (5), 116-119. doi:10.5455/IJMRCR.granulomatosis-polyangiitis