E-ISSN 2534-9821
 

Original Research 


Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy

Denny Moniaga, Syakib Bakri, Haerani Rasyid, Tutik Harjiyanti, Hasyim Kasim, Sahyudin Saleh, Muhammad Ilyas, Arifin Seweng.

Abstract
Background: Acute kidney injury in malignant subjects can be caused by the process of the malignant itself or its therapy, in this case chemotherapy. Neutrophil Gelatinase Associated Lipocalin detects acute renal injury earlier than creatinine. This study measure the dynamics of Neutrophil Gelatinase Associated Lipocalin serum in malignant subjects treated with chemotherapy.
Method: Analytical research with cohort design. The research subjects were subjects aged > 18 years treated with chemotherapy at Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Serum level of Neutrophil Gelatinase Associated Lipocalin measured before and 24 hours after chemotherapy.
Results: Post-chemotherapy Neutrophil Gelatinase Associated Lipocalin serum level was significantly higher than pre-chemotherapy (280,330 ng / ml vs. 204,453 ng / ml, p <0,001). The increased percentage of Neutrophil Gelatinase Associated Lipocalin serum level was significantly higher in subjects with serum creatinine level > 1.3 mg / dl compared to subjects with serum creatinine level < 1.3 mg / dl (185% vs 52%, p <0, 05). The increased percentage of Neutrophil Gelatinase Associated Lipocalin serum level was found to be higher in subjects with diabetes and / or hypertension than those without diabetes and / or hypertension (160% vs 48%, p <0.05).
Discussion: This study found overall increased of Neutrophil Gelatinase Associated Lipocalin serum level in malignant patients 24 hours after chemotherapy, especially in patients with serum creatinine > 1.3 mg/dl and with diabetes and/or hypertension. Possible explanation is previous kidney injury, hypertension, and diabetes melitus makes kidney vulnerable to nephrotoxic substances.

Key words: Neutrophil Gelatinase Associated Lipocalin, acute kidney injury, malignancy, chemotherapy


 
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How to Cite this Article
Pubmed Style

Moniaga D, Bakri S, Rasyid H, Harjiyanti T, Kasim H, Saleh S, Ilyas M, Seweng A. Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. Int J Med Rev Case Rep. 2019; 3(1): 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy


Web Style

Moniaga D, Bakri S, Rasyid H, Harjiyanti T, Kasim H, Saleh S, Ilyas M, Seweng A. Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. http://mdpub.net/?mno=19296 [Access: February 18, 2019]. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy


AMA (American Medical Association) Style

Moniaga D, Bakri S, Rasyid H, Harjiyanti T, Kasim H, Saleh S, Ilyas M, Seweng A. Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. Int J Med Rev Case Rep. 2019; 3(1): 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy



Vancouver/ICMJE Style

Moniaga D, Bakri S, Rasyid H, Harjiyanti T, Kasim H, Saleh S, Ilyas M, Seweng A. Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. Int J Med Rev Case Rep. (2019), [cited February 18, 2019]; 3(1): 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy



Harvard Style

Moniaga, D., Bakri, . S., Rasyid, . H., Harjiyanti, . T., Kasim, . H., Saleh, . S., Ilyas, . M. & Seweng, . A. (2019) Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. Int J Med Rev Case Rep, 3 (1), 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy



Turabian Style

Moniaga, Denny, Syakib Bakri, Haerani Rasyid, Tutik Harjiyanti, Hasyim Kasim, Sahyudin Saleh, Muhammad Ilyas, and Arifin Seweng. 2019. Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. International Journal of Medical Reviews and Case Reports, 3 (1), 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy



Chicago Style

Moniaga, Denny, Syakib Bakri, Haerani Rasyid, Tutik Harjiyanti, Hasyim Kasim, Sahyudin Saleh, Muhammad Ilyas, and Arifin Seweng. "Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy." International Journal of Medical Reviews and Case Reports 3 (2019), 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy



MLA (The Modern Language Association) Style

Moniaga, Denny, Syakib Bakri, Haerani Rasyid, Tutik Harjiyanti, Hasyim Kasim, Sahyudin Saleh, Muhammad Ilyas, and Arifin Seweng. "Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy." International Journal of Medical Reviews and Case Reports 3.1 (2019), 1-4. Print. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy



APA (American Psychological Association) Style

Moniaga, D., Bakri, . S., Rasyid, . H., Harjiyanti, . T., Kasim, . H., Saleh, . S., Ilyas, . M. & Seweng, . A. (2019) Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. International Journal of Medical Reviews and Case Reports, 3 (1), 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy