E-ISSN 2534-9821
 

Original Research 


The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level

Asvina Anis Anwar, Farida Tabri, Anni Adriani, Khairuddin Djawad, Agussalim Bukhari, Ilhamjaya Patellongi.

Abstract
Introduction: Reactive oxygen species (ROS) are produced continuously in our body as a result of biochemical reactions which may cause oxidative stress and various dysfunctions. Antioxidants are substances which are postulated to prevent or even overcome the adverse effects of free radicals. Glutathione is a type of antioxidant that is required for maintaining mitochondrial function, DNA health, improving immune function and providing anti-inflammatory effects. However, the benefit of glutathione as a health supplement in healthy individuals is yet to be elucidated.
Method: a total of 30 healthy women was included in this double-blinded randomized controlled trial study. Subjects were randomly allocated into two groups receiving placebo and antioxidant capsule, respectively. One capsule of antioxidant contains 500 mg L-glutathione, 250 mg ascorbic acid, 50 mg alpha-lipoic acid (ALA), and 4 mg zinc which was given every day to the treatment group for 12 weeks. The total antioxidant serum (TAS) level before and after 12 weeks of treatment was examined using ELISA.
Result: No significant TAS level difference was observed between both groups before and after treatment (p>0.05). In addition, there was also no significant difference in TAS level within the group before and after 12 weeks of treatment (p>0.05). No significant side effects were observed.
Conclusion: This study shows that short term administration of antioxidant supplement containing glutathione, ascorbic acid, ALA, and zinc did not significantly affect the antioxidant level.

Key words: alpha lipoic acid, glutathione, total antioxidant status, vitamin C, zinc


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Asvina Anis Anwar
Articles by Farida Tabri
Articles by Anni Adriani
Articles by Khairuddin Djawad
Articles by Agussalim Bukhari
Articles by Ilhamjaya Patellongi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Anwar AA, Tabri F, Adriani A, Djawad K, Bukhari A, Patellongi I, . The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level. Int J Med Rev Case Rep. 2019; 3(5): 195-197. doi:10.5455/IJMRCR.Glutathione-Supplementation-TAS


Web Style

Anwar AA, Tabri F, Adriani A, Djawad K, Bukhari A, Patellongi I, . The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level. http://www.mdpub.net/?mno=21112 [Access: August 11, 2020]. doi:10.5455/IJMRCR.Glutathione-Supplementation-TAS


AMA (American Medical Association) Style

Anwar AA, Tabri F, Adriani A, Djawad K, Bukhari A, Patellongi I, . The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level. Int J Med Rev Case Rep. 2019; 3(5): 195-197. doi:10.5455/IJMRCR.Glutathione-Supplementation-TAS



Vancouver/ICMJE Style

Anwar AA, Tabri F, Adriani A, Djawad K, Bukhari A, Patellongi I, . The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level. Int J Med Rev Case Rep. (2019), [cited August 11, 2020]; 3(5): 195-197. doi:10.5455/IJMRCR.Glutathione-Supplementation-TAS



Harvard Style

Anwar, A. A., Tabri, F. ., Adriani, A. ., Djawad, K. ., Bukhari, A. ., Patellongi, I. . & (2019) The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level. Int J Med Rev Case Rep, 3 (5), 195-197. doi:10.5455/IJMRCR.Glutathione-Supplementation-TAS



Turabian Style

Anwar, Asvina Anis, Farida Tabri, Anni Adriani, Khairuddin Djawad, Agussalim Bukhari, Ilhamjaya Patellongi, and . 2019. The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level. International Journal of Medical Reviews and Case Reports, 3 (5), 195-197. doi:10.5455/IJMRCR.Glutathione-Supplementation-TAS



Chicago Style

Anwar, Asvina Anis, Farida Tabri, Anni Adriani, Khairuddin Djawad, Agussalim Bukhari, Ilhamjaya Patellongi, and . "The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level." International Journal of Medical Reviews and Case Reports 3 (2019), 195-197. doi:10.5455/IJMRCR.Glutathione-Supplementation-TAS



MLA (The Modern Language Association) Style

Anwar, Asvina Anis, Farida Tabri, Anni Adriani, Khairuddin Djawad, Agussalim Bukhari, Ilhamjaya Patellongi, and . "The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level." International Journal of Medical Reviews and Case Reports 3.5 (2019), 195-197. Print. doi:10.5455/IJMRCR.Glutathione-Supplementation-TAS



APA (American Psychological Association) Style

Anwar, A. A., Tabri, F. ., Adriani, A. ., Djawad, K. ., Bukhari, A. ., Patellongi, I. . & (2019) The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level. International Journal of Medical Reviews and Case Reports, 3 (5), 195-197. doi:10.5455/IJMRCR.Glutathione-Supplementation-TAS