E-ISSN 2534-9821
 

Review Article 


Middle Eastern Respiratory Syndrome: A Brief Review

MOHAMMAD SHAHID IQBAL, MOHAMMAD BASALAMAH, ABDULRAHMAN ALMEHMADI, AHMED AL SAEEDI, AYMAN ABDULLAH ALZAHRANI, ABDULAZIZ SALEH ALMEHMADI, ABDULAZIZ ALBESHRI, AISHA TABASSUM.

Abstract
Middle East respiratory syndrome is a zoonotic viral disease caused by a novel Coronavirus named Middle East Respiratory Syndrome-Coronavirus (MERS-CoV). More than 1806 cases have been reported in human beings till the end of 2016 with a fatality rate of more than 30%. Majority of the cases have been reported from Saudi Arabia. Many healthcare associated outbreaks have been reported with the largest such outbreak being reported from Republic of Korea in 2015, where 186 cases including 36 deaths occurred. MERS is a viral pneumonia with rapidly progressive respiratory failure leading to ARDS. It presents with a wide range of clinical manifestations and associated with significant mortality rates in hospital admitted patients with comorbidities. Multiple surveillance and phylogenetic studies suggest a bat origin for this virus.A diagnostic real time reverse transcription polymerase chain reaction (RT- PCR) is done to detect MERS-CoV .Supportive treatment is the mainstay of management as no specific drug treatment exists for MERS. Resveratrol has shown to inhibit MERS-CoV infection and prolong cellular survival after virus infection. It is also inhibited by interferon type I in cultured cells. Adequate infection control measures are the mainstay in the management of MERS-CoV. Surveillance should be conducted on a large scale among humans and different animal species to determine the exact rate of spread of MERS-CoV.

Key words: Coronavirus, Pneumonia, Resveratrol


 
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How to Cite this Article
Pubmed Style

IQBAL MS, BASALAMAH M, ALMEHMADI A, SAEEDI AA, ALZAHRANI AA, ALMEHMADI AS, ALBESHRI A, TABASSUM A. Middle Eastern Respiratory Syndrome: A Brief Review. Int J Med Rev Case Rep. 2019; 3(5): 227-231. doi:10.5455/IJMRCR.MIDDLE-EASTERN-RESPIRATORY-SYNDROME


Web Style

IQBAL MS, BASALAMAH M, ALMEHMADI A, SAEEDI AA, ALZAHRANI AA, ALMEHMADI AS, ALBESHRI A, TABASSUM A. Middle Eastern Respiratory Syndrome: A Brief Review. http://www.mdpub.net/?mno=27174 [Access: January 28, 2020]. doi:10.5455/IJMRCR.MIDDLE-EASTERN-RESPIRATORY-SYNDROME


AMA (American Medical Association) Style

IQBAL MS, BASALAMAH M, ALMEHMADI A, SAEEDI AA, ALZAHRANI AA, ALMEHMADI AS, ALBESHRI A, TABASSUM A. Middle Eastern Respiratory Syndrome: A Brief Review. Int J Med Rev Case Rep. 2019; 3(5): 227-231. doi:10.5455/IJMRCR.MIDDLE-EASTERN-RESPIRATORY-SYNDROME



Vancouver/ICMJE Style

IQBAL MS, BASALAMAH M, ALMEHMADI A, SAEEDI AA, ALZAHRANI AA, ALMEHMADI AS, ALBESHRI A, TABASSUM A. Middle Eastern Respiratory Syndrome: A Brief Review. Int J Med Rev Case Rep. (2019), [cited January 28, 2020]; 3(5): 227-231. doi:10.5455/IJMRCR.MIDDLE-EASTERN-RESPIRATORY-SYNDROME



Harvard Style

IQBAL, M. S., BASALAMAH, . M., ALMEHMADI, . A., SAEEDI, . A. A., ALZAHRANI, . A. A., ALMEHMADI, . A. S., ALBESHRI, . A. & TABASSUM, . A. (2019) Middle Eastern Respiratory Syndrome: A Brief Review. Int J Med Rev Case Rep, 3 (5), 227-231. doi:10.5455/IJMRCR.MIDDLE-EASTERN-RESPIRATORY-SYNDROME



Turabian Style

IQBAL, MOHAMMAD SHAHID, MOHAMMAD BASALAMAH, ABDULRAHMAN ALMEHMADI, AHMED AL SAEEDI, AYMAN ABDULLAH ALZAHRANI, ABDULAZIZ SALEH ALMEHMADI, ABDULAZIZ ALBESHRI, and AISHA TABASSUM. 2019. Middle Eastern Respiratory Syndrome: A Brief Review. International Journal of Medical Reviews and Case Reports, 3 (5), 227-231. doi:10.5455/IJMRCR.MIDDLE-EASTERN-RESPIRATORY-SYNDROME



Chicago Style

IQBAL, MOHAMMAD SHAHID, MOHAMMAD BASALAMAH, ABDULRAHMAN ALMEHMADI, AHMED AL SAEEDI, AYMAN ABDULLAH ALZAHRANI, ABDULAZIZ SALEH ALMEHMADI, ABDULAZIZ ALBESHRI, and AISHA TABASSUM. "Middle Eastern Respiratory Syndrome: A Brief Review." International Journal of Medical Reviews and Case Reports 3 (2019), 227-231. doi:10.5455/IJMRCR.MIDDLE-EASTERN-RESPIRATORY-SYNDROME



MLA (The Modern Language Association) Style

IQBAL, MOHAMMAD SHAHID, MOHAMMAD BASALAMAH, ABDULRAHMAN ALMEHMADI, AHMED AL SAEEDI, AYMAN ABDULLAH ALZAHRANI, ABDULAZIZ SALEH ALMEHMADI, ABDULAZIZ ALBESHRI, and AISHA TABASSUM. "Middle Eastern Respiratory Syndrome: A Brief Review." International Journal of Medical Reviews and Case Reports 3.5 (2019), 227-231. Print. doi:10.5455/IJMRCR.MIDDLE-EASTERN-RESPIRATORY-SYNDROME



APA (American Psychological Association) Style

IQBAL, M. S., BASALAMAH, . M., ALMEHMADI, . A., SAEEDI, . A. A., ALZAHRANI, . A. A., ALMEHMADI, . A. S., ALBESHRI, . A. & TABASSUM, . A. (2019) Middle Eastern Respiratory Syndrome: A Brief Review. International Journal of Medical Reviews and Case Reports, 3 (5), 227-231. doi:10.5455/IJMRCR.MIDDLE-EASTERN-RESPIRATORY-SYNDROME