E-ISSN 2534-9821
 

Review Article 


Molecular Pathology In Lung Cancer: A Brief Review

I. Ebru Cakir.

Abstract
Lung cancer is a heterogenous tumor which develops as a result of accumulation of multiple genetic, and epigenetic changes together with environmental pathogens. In the last decade, targetable specific molecular changes were described, and important developments in the treatment, and survival of these patients have been obtained. In recent years, with recommendations of international guidelines, analyses of molecular changes related to sensitivity to tyrosine kinase inhibitors as EGFR gene mutations , and ALK/ROS gene rearrangements have been performed in many laboratories in cases with advanced stage non-small cell carcinomas. Inclusion of BRAF, MET, RET, HER2, and KRAS genes in the next generation sequencing panels, and analysis of EGFR T790M mutations related to the resistance to tyrosine kinase inhibitors are recommended. As the knowledge, and studies about genes, and mechanisms increase, determination and analysis of the laboratory tests for the markers which play roles in the patient selection will develop.

Key words: Lung cancer, gene, molecular pathology, analysis


 
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Pubmed Style

I. Ebru Cakir. Molecular Pathology In Lung Cancer: A Brief Review. Int J Med Rev Case Rep. 2019; 3(1): 10-15. doi:10.5455/IJMRCR.MOLECULAR-PATHOLOGY-IN-LUNG-CANCER


Web Style

I. Ebru Cakir. Molecular Pathology In Lung Cancer: A Brief Review. http://mdpub.net/?mno=27264 [Access: February 17, 2019]. doi:10.5455/IJMRCR.MOLECULAR-PATHOLOGY-IN-LUNG-CANCER


AMA (American Medical Association) Style

I. Ebru Cakir. Molecular Pathology In Lung Cancer: A Brief Review. Int J Med Rev Case Rep. 2019; 3(1): 10-15. doi:10.5455/IJMRCR.MOLECULAR-PATHOLOGY-IN-LUNG-CANCER



Vancouver/ICMJE Style

I. Ebru Cakir. Molecular Pathology In Lung Cancer: A Brief Review. Int J Med Rev Case Rep. (2019), [cited February 17, 2019]; 3(1): 10-15. doi:10.5455/IJMRCR.MOLECULAR-PATHOLOGY-IN-LUNG-CANCER



Harvard Style

I. Ebru Cakir (2019) Molecular Pathology In Lung Cancer: A Brief Review. Int J Med Rev Case Rep, 3 (1), 10-15. doi:10.5455/IJMRCR.MOLECULAR-PATHOLOGY-IN-LUNG-CANCER



Turabian Style

I. Ebru Cakir. 2019. Molecular Pathology In Lung Cancer: A Brief Review. International Journal of Medical Reviews and Case Reports, 3 (1), 10-15. doi:10.5455/IJMRCR.MOLECULAR-PATHOLOGY-IN-LUNG-CANCER



Chicago Style

I. Ebru Cakir. "Molecular Pathology In Lung Cancer: A Brief Review." International Journal of Medical Reviews and Case Reports 3 (2019), 10-15. doi:10.5455/IJMRCR.MOLECULAR-PATHOLOGY-IN-LUNG-CANCER



MLA (The Modern Language Association) Style

I. Ebru Cakir. "Molecular Pathology In Lung Cancer: A Brief Review." International Journal of Medical Reviews and Case Reports 3.1 (2019), 10-15. Print. doi:10.5455/IJMRCR.MOLECULAR-PATHOLOGY-IN-LUNG-CANCER



APA (American Psychological Association) Style

I. Ebru Cakir (2019) Molecular Pathology In Lung Cancer: A Brief Review. International Journal of Medical Reviews and Case Reports, 3 (1), 10-15. doi:10.5455/IJMRCR.MOLECULAR-PATHOLOGY-IN-LUNG-CANCER