E-ISSN 2534-9821
 
2023, Vol: 7, Issue: 6
7 / 6Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Copyright Transfer Form

Case Report

Online Publishing Date:
10 / 12 / 2020

 


Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases

Vipal Parmar, Bhavna Mehta, Sandip Shah, Rahul Yadav, Mandava Rao.


Abstract
Leiomyosarcoma (LMS) of the colo-rectum is a rare malignant entity with unfavourable prognosis, and responds poorly to conventional chemo-radiation therapy. Only a few cases of the LMS of colorectum have so far been reported earlier. Here we report two such cases of primary leiomyosarcoma of sigmoid colon and rectum. Due to histological similarity with gastrointestinal stromal tumour (GIST), the LMS cases were misdiagnosed as GIST. This is essentially a pathological diagnosis having a similar histomorphological appearance that of GIST, but a different Immunohistochemistry profile, in contrast to GIST. Immunohistocytochemically LMS are negative for CD34, CD117 and DOG1 and positive for desmin as detected in this report. GIST is curable with surgery followed by imatinib (in intermediate /high-risk patients) while LMS behaves aggressively requiring radical excision of the tumour followed by intensive cytotoxic chemotherapy regimens. Thus it is important to diagnose LMS definitively by immunohistochemical profiling as the prognosis and treatment of these tumours vary from others as mentioned.

Key words: Leiomyosarcoma, colon, rectum, Immunohistochemistry, Rare case


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Vipal Parmar
Articles by Bhavna Mehta
Articles by Sandip Shah
Articles by Rahul Yadav
Articles by Mandava Rao
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Parmar V, Mehta B, Shah S, Yadav R, Rao M. Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. Int J Med Rev Case Rep. 2021; 5(1): 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON

Web Style

Parmar V, Mehta B, Shah S, Yadav R, Rao M. Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. https://www.mdpub.net/?mno=29416 [Access: April 04, 2024]. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON

AMA (American Medical Association) Style

Parmar V, Mehta B, Shah S, Yadav R, Rao M. Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. Int J Med Rev Case Rep. 2021; 5(1): 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


Vancouver/ICMJE Style

Parmar V, Mehta B, Shah S, Yadav R, Rao M. Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. Int J Med Rev Case Rep. (2021), [cited April 04, 2024]; 5(1): 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


Harvard Style

Parmar, V., Mehta, . B., Shah, . S., Yadav, . R. & Rao, . M. (2021) Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. Int J Med Rev Case Rep, 5 (1), 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


Turabian Style

Parmar, Vipal, Bhavna Mehta, Sandip Shah, Rahul Yadav, and Mandava Rao. 2021. Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. International Journal of Medical Reviews and Case Reports, 5 (1), 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


Chicago Style

Parmar, Vipal, Bhavna Mehta, Sandip Shah, Rahul Yadav, and Mandava Rao. "Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases." International Journal of Medical Reviews and Case Reports 5 (2021), 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


MLA (The Modern Language Association) Style

Parmar, Vipal, Bhavna Mehta, Sandip Shah, Rahul Yadav, and Mandava Rao. "Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases." International Journal of Medical Reviews and Case Reports 5.1 (2021), 36-38. Print. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


APA (American Psychological Association) Style

Parmar, V., Mehta, . B., Shah, . S., Yadav, . R. & Rao, . M. (2021) Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. International Journal of Medical Reviews and Case Reports, 5 (1), 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About International Journal of Medical Reviews and Case Reports

International Journal of Medical Reviews and Case Reports  (Int J Med Rev Case Rep)ISSN: 2534-9821The International Journal of Medical Reviews and Ca ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Any correspondence, queries or additional requests for information on the manuscript submission process should be sent to the International Journal of Medical Reviews and Case Reports editorial office as follows:

Bulgarian Association of Young Surgeons (BAYS);

National Center of Public Health and Analyses (NCPHA), floor 2, office № 31,  Sofia 1431, Bulgaria.

inkov@journalmedica.com

Financial department is managed by International Sci Ink Press. 

It is a company registered in Bulgaria with registered no. 205414288 and registered address at 57 Antim I str., Vazrazhdane, Sofia, 1303, Bulgaria.

Tel: +359883427500