E-ISSN 2534-9821
 

Original Research 


Factors that influence the incidence of drug induced liver injury in pulmonary tuberculosis patient

Muhammad Jabal Nur, Harun Iskandar, Nu'man AS Daud, Syakib Bakri, Hasyim Kasim, Nur Ahmad Tabri, Fardah Akil, Arifin Seweng.

Abstract
Background: The use of anti-tuberculosis drugs (ATD) is not uncommon to find side effects that complicate treatment. One of the side effects caused by ATD treatment is Drug Induced Liver Injury (DILI). Risk factors that trigger the incidence of DILI during tuberculosis (TB) treatment involving variety of factors. This study was conducted to determine the risk factors of DILI in pulmonary tuberculosis patient.
Method: Conducted retrospective case-control study. Study subjects were all patients who underwent first category ATD treatment at Dr. Wahidin Sudirohusodo hospital of Makassar, Indonesia. Risk factors examined were age, gender, nutritional status, alcohol consumption, smoking, history of liver disease, consumption of other drug, ATD preparation of Fixed Dose Combination (FDC) and abnormality of SGPT/ total bilirubin control value at minimum of 2 weeks after starting treatment.
Result: from total 47 samples who took part in the study, 10 samples (21.3%) suffered DILI. Samples characteristics who suffered from DILI, were an average age of 52.7 years old (P < 0.05), and consumption of other drug 29.4% (P < 0.05). There was no significant relationship between gender, nutritional status, alcohol consumption, smoking, and history of liver disease in the incidence of DILI.
Conclusion: Old age and history of consumption of other drug has significant relationship as a risk factors for the incidence of DILI in TB patients who consume ATD, while no significant relationship found between gender, malnutrition, alcohol consumption, smoking, and history of liver disease.

Key words: DILI, Pulmonary, Tuberculosis, ATD


 
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How to Cite this Article
Pubmed Style

Nur MJ, Iskandar H, Daud NA, Bakri S, Kasim H, Tabri NA, Akil F, Seweng A. Factors that influence the incidence of drug induced liver injury in pulmonary tuberculosis patient. Int J Med Rev Case Rep. 2019; 3(6): 303-305. doi:10.5455/IJMRCR.drug-induced-liver-injury-pulmonary-tuberculosis


Web Style

Nur MJ, Iskandar H, Daud NA, Bakri S, Kasim H, Tabri NA, Akil F, Seweng A. Factors that influence the incidence of drug induced liver injury in pulmonary tuberculosis patient. http://mdpub.net/?mno=34373 [Access: July 17, 2019]. doi:10.5455/IJMRCR.drug-induced-liver-injury-pulmonary-tuberculosis


AMA (American Medical Association) Style

Nur MJ, Iskandar H, Daud NA, Bakri S, Kasim H, Tabri NA, Akil F, Seweng A. Factors that influence the incidence of drug induced liver injury in pulmonary tuberculosis patient. Int J Med Rev Case Rep. 2019; 3(6): 303-305. doi:10.5455/IJMRCR.drug-induced-liver-injury-pulmonary-tuberculosis



Vancouver/ICMJE Style

Nur MJ, Iskandar H, Daud NA, Bakri S, Kasim H, Tabri NA, Akil F, Seweng A. Factors that influence the incidence of drug induced liver injury in pulmonary tuberculosis patient. Int J Med Rev Case Rep. (2019), [cited July 17, 2019]; 3(6): 303-305. doi:10.5455/IJMRCR.drug-induced-liver-injury-pulmonary-tuberculosis



Harvard Style

Nur, M. J., Iskandar, . H., Daud, . N. A., Bakri, . S., Kasim, . H., Tabri, . N. A., Akil, . F. & Seweng, . A. (2019) Factors that influence the incidence of drug induced liver injury in pulmonary tuberculosis patient. Int J Med Rev Case Rep, 3 (6), 303-305. doi:10.5455/IJMRCR.drug-induced-liver-injury-pulmonary-tuberculosis



Turabian Style

Nur, Muhammad Jabal, Harun Iskandar, Numan AS Daud, Syakib Bakri, Hasyim Kasim, Nur Ahmad Tabri, Fardah Akil, and Arifin Seweng. 2019. Factors that influence the incidence of drug induced liver injury in pulmonary tuberculosis patient. International Journal of Medical Reviews and Case Reports, 3 (6), 303-305. doi:10.5455/IJMRCR.drug-induced-liver-injury-pulmonary-tuberculosis



Chicago Style

Nur, Muhammad Jabal, Harun Iskandar, Numan AS Daud, Syakib Bakri, Hasyim Kasim, Nur Ahmad Tabri, Fardah Akil, and Arifin Seweng. "Factors that influence the incidence of drug induced liver injury in pulmonary tuberculosis patient." International Journal of Medical Reviews and Case Reports 3 (2019), 303-305. doi:10.5455/IJMRCR.drug-induced-liver-injury-pulmonary-tuberculosis



MLA (The Modern Language Association) Style

Nur, Muhammad Jabal, Harun Iskandar, Numan AS Daud, Syakib Bakri, Hasyim Kasim, Nur Ahmad Tabri, Fardah Akil, and Arifin Seweng. "Factors that influence the incidence of drug induced liver injury in pulmonary tuberculosis patient." International Journal of Medical Reviews and Case Reports 3.6 (2019), 303-305. Print. doi:10.5455/IJMRCR.drug-induced-liver-injury-pulmonary-tuberculosis



APA (American Psychological Association) Style

Nur, M. J., Iskandar, . H., Daud, . N. A., Bakri, . S., Kasim, . H., Tabri, . N. A., Akil, . F. & Seweng, . A. (2019) Factors that influence the incidence of drug induced liver injury in pulmonary tuberculosis patient. International Journal of Medical Reviews and Case Reports, 3 (6), 303-305. doi:10.5455/IJMRCR.drug-induced-liver-injury-pulmonary-tuberculosis