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Original Research (Original Article) 


Expressions of basic fibroblast growth factor in the peptic ulcer healing due the nonsteroidal anti-inflammatory drugs

Husain , Fardah Akil, Nu man AS Daud, Susanto H Kusuma, AM Luthfi Parewangi, Rini R Bachtiar, Syakib Bakri, Faridin HP, Erwin Arief, Agus Sudarso, Arifin Seweng.

Abstract
Background: Basic Fibroblast Growth Factor (bFGF) or FGF2 is the most active angiogenic peptide and plays important role in the pathogenesis of ulcers healing. High levels of bFGF have been describe in healing ulcer in gastrointestinal (GI) or systemic disease. However, its role in phase of peptic ulcer especially at NSAIDs user remains limited data in human. This study was to know the expressions of bFGF in the process of NSAID-induced peptic ulcer healing.
Method: Peptic ulcer biopsies were processed for immunohistochemical staining characterization from 46 patients with a history of NSAIDs consumption and upper GI bleeding. Expression of bFGF was quantified as semiquantitative scoring of positive stain as a whole (from 0-+3). Phase evaluation of healing peptic ulcer (Active=A), Healing=H, Cicatrix=C) by Sakita and Fukotomi endoscopy classification.
Results: Twenty-seven (58,7%) subject were male patient, mean age 61 8 years and most frequently consumed NSAIDs are meloxicam (12/26,1%). Majority of the subject was in active (A) phase of peptic ulcer healing (27/58,7%). Expression of bFGF was significantly higher in patients with A phase (2.40,5) compared with H and C Phase (1.20.4; 0.40.5 respectively; p<0.001)
Conclusion: Increased expressions of bFGF in active phase of peptic ulcer while decline in phase of healing and cicatrix patiens with NSAID, confirms its important role in pathogenesis healing of peptic ulcer.

Key words: bFGF, Peptic ulcer, NSAIDs


 
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How to Cite this Article
Pubmed Style

H, Akil F, Daud NmA, Kusuma SH, Parewangi AL, Bachtiar RR, Bakri S, HP F, Arief E, Sudarso A, Seweng A, . Expressions of basic fibroblast growth factor in the peptic ulcer healing due the nonsteroidal anti-inflammatory drugs. Int J Med Rev Case Rep. 2019; 3(11): 697-701. doi:10.5455/IJMRCR.fibroblast-growth


Web Style

H, Akil F, Daud NmA, Kusuma SH, Parewangi AL, Bachtiar RR, Bakri S, HP F, Arief E, Sudarso A, Seweng A, . Expressions of basic fibroblast growth factor in the peptic ulcer healing due the nonsteroidal anti-inflammatory drugs. http://www.mdpub.net/?mno=39520 [Access: July 15, 2020]. doi:10.5455/IJMRCR.fibroblast-growth


AMA (American Medical Association) Style

H, Akil F, Daud NmA, Kusuma SH, Parewangi AL, Bachtiar RR, Bakri S, HP F, Arief E, Sudarso A, Seweng A, . Expressions of basic fibroblast growth factor in the peptic ulcer healing due the nonsteroidal anti-inflammatory drugs. Int J Med Rev Case Rep. 2019; 3(11): 697-701. doi:10.5455/IJMRCR.fibroblast-growth



Vancouver/ICMJE Style

H, Akil F, Daud NmA, Kusuma SH, Parewangi AL, Bachtiar RR, Bakri S, HP F, Arief E, Sudarso A, Seweng A, . Expressions of basic fibroblast growth factor in the peptic ulcer healing due the nonsteroidal anti-inflammatory drugs. Int J Med Rev Case Rep. (2019), [cited July 15, 2020]; 3(11): 697-701. doi:10.5455/IJMRCR.fibroblast-growth



Harvard Style

, H., Akil, F., Daud, N. m. A., Kusuma, S. H., Parewangi, A. L., Bachtiar, R. R., Bakri, S., HP, F., Arief, E., Sudarso, A., Seweng, A. & (2019) Expressions of basic fibroblast growth factor in the peptic ulcer healing due the nonsteroidal anti-inflammatory drugs. Int J Med Rev Case Rep, 3 (11), 697-701. doi:10.5455/IJMRCR.fibroblast-growth



Turabian Style

, Husain, Fardah Akil, Nu man AS Daud, Susanto H Kusuma, AM Luthfi Parewangi, Rini R Bachtiar, Syakib Bakri, Faridin HP, Erwin Arief, Agus Sudarso, Arifin Seweng, and . 2019. Expressions of basic fibroblast growth factor in the peptic ulcer healing due the nonsteroidal anti-inflammatory drugs. International Journal of Medical Reviews and Case Reports, 3 (11), 697-701. doi:10.5455/IJMRCR.fibroblast-growth



Chicago Style

, Husain, Fardah Akil, Nu man AS Daud, Susanto H Kusuma, AM Luthfi Parewangi, Rini R Bachtiar, Syakib Bakri, Faridin HP, Erwin Arief, Agus Sudarso, Arifin Seweng, and . "Expressions of basic fibroblast growth factor in the peptic ulcer healing due the nonsteroidal anti-inflammatory drugs." International Journal of Medical Reviews and Case Reports 3 (2019), 697-701. doi:10.5455/IJMRCR.fibroblast-growth



MLA (The Modern Language Association) Style

, Husain, Fardah Akil, Nu man AS Daud, Susanto H Kusuma, AM Luthfi Parewangi, Rini R Bachtiar, Syakib Bakri, Faridin HP, Erwin Arief, Agus Sudarso, Arifin Seweng, and . "Expressions of basic fibroblast growth factor in the peptic ulcer healing due the nonsteroidal anti-inflammatory drugs." International Journal of Medical Reviews and Case Reports 3.11 (2019), 697-701. Print. doi:10.5455/IJMRCR.fibroblast-growth



APA (American Psychological Association) Style

, H., Akil, F., Daud, N. m. A., Kusuma, S. H., Parewangi, A. L., Bachtiar, R. R., Bakri, S., HP, F., Arief, E., Sudarso, A., Seweng, A. & (2019) Expressions of basic fibroblast growth factor in the peptic ulcer healing due the nonsteroidal anti-inflammatory drugs. International Journal of Medical Reviews and Case Reports, 3 (11), 697-701. doi:10.5455/IJMRCR.fibroblast-growth