E-ISSN 2534-9821
 

Original Research 


Polymorphısm ın the inducıble nıtrıc oxıde synthase gene ınpatıent susceptıbılıty spınal tuberculosıs

Jainal Arifin, Karya Triko Biakto, Andry Usman, Muh Nasrum Massi, Nur Rahmansyah, Mirza Ariandi, Padlan Pasallo, Ery Wildan.

Abstract
Spinal Tuberculosis is an infection of the spine caused by Mycobacterium Tuberculosis. It is an extrapulmonary complication of Mycobacterium Tuberculosis infection. The purpose of this study was to determine whether there is a NOS 2A gene polymorphism so that patients are susceptible to tuberculosis spondylitis. This study is an analytical cross-sectional study on 36 Spinal tuberculosis patients at the Wahidin Sudirohusodo Hospital in Makassar who had tested positive TB geneXpert and took 5 ml of blood samples in EDTA tubes. Then DNA extraction and genotyping examination with PCR techniques were carried out.
There were 39 subjects in this study 39 TB spondylitis patients (84.8%) and 7 controls (15.2%). Most of them were women (58.7%), aged between 20-29 years (41.3%). Based on PCR results, only 2 subjects experienced a gene mutation (4.3%) in the A-277G single nucleotide. The NOS2A gene polymorphism is a cause of susceptibility to spinal tuberculosis.

Key words: Spinal Tuberculosis, Polymorphism, Inducible Nitric Oxide Synthase, NOS 2A


 
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How to Cite this Article
Pubmed Style

Arifin J, Biakto KT, Usman A, Massi MN, Rahmansyah N, Ariandi M, Pasallo P, Wildan E. Polymorphısm ın the inducıble nıtrıc oxıde synthase gene ınpatıent susceptıbılıty spınal tuberculosıs. Int J Med Rev Case Rep. 2019; 3(12): 819-822. doi:10.5455/IJMRCR.spine-tuberculosis


Web Style

Arifin J, Biakto KT, Usman A, Massi MN, Rahmansyah N, Ariandi M, Pasallo P, Wildan E. Polymorphısm ın the inducıble nıtrıc oxıde synthase gene ınpatıent susceptıbılıty spınal tuberculosıs. http://www.mdpub.net/?mno=48607 [Access: September 27, 2020]. doi:10.5455/IJMRCR.spine-tuberculosis


AMA (American Medical Association) Style

Arifin J, Biakto KT, Usman A, Massi MN, Rahmansyah N, Ariandi M, Pasallo P, Wildan E. Polymorphısm ın the inducıble nıtrıc oxıde synthase gene ınpatıent susceptıbılıty spınal tuberculosıs. Int J Med Rev Case Rep. 2019; 3(12): 819-822. doi:10.5455/IJMRCR.spine-tuberculosis



Vancouver/ICMJE Style

Arifin J, Biakto KT, Usman A, Massi MN, Rahmansyah N, Ariandi M, Pasallo P, Wildan E. Polymorphısm ın the inducıble nıtrıc oxıde synthase gene ınpatıent susceptıbılıty spınal tuberculosıs. Int J Med Rev Case Rep. (2019), [cited September 27, 2020]; 3(12): 819-822. doi:10.5455/IJMRCR.spine-tuberculosis



Harvard Style

Arifin, J., Biakto, . K. T., Usman, . A., Massi, . M. N., Rahmansyah, . N., Ariandi, . M., Pasallo, . P. & Wildan, . E. (2019) Polymorphısm ın the inducıble nıtrıc oxıde synthase gene ınpatıent susceptıbılıty spınal tuberculosıs. Int J Med Rev Case Rep, 3 (12), 819-822. doi:10.5455/IJMRCR.spine-tuberculosis



Turabian Style

Arifin, Jainal, Karya Triko Biakto, Andry Usman, Muh Nasrum Massi, Nur Rahmansyah, Mirza Ariandi, Padlan Pasallo, and Ery Wildan. 2019. Polymorphısm ın the inducıble nıtrıc oxıde synthase gene ınpatıent susceptıbılıty spınal tuberculosıs. International Journal of Medical Reviews and Case Reports, 3 (12), 819-822. doi:10.5455/IJMRCR.spine-tuberculosis



Chicago Style

Arifin, Jainal, Karya Triko Biakto, Andry Usman, Muh Nasrum Massi, Nur Rahmansyah, Mirza Ariandi, Padlan Pasallo, and Ery Wildan. "Polymorphısm ın the inducıble nıtrıc oxıde synthase gene ınpatıent susceptıbılıty spınal tuberculosıs." International Journal of Medical Reviews and Case Reports 3 (2019), 819-822. doi:10.5455/IJMRCR.spine-tuberculosis



MLA (The Modern Language Association) Style

Arifin, Jainal, Karya Triko Biakto, Andry Usman, Muh Nasrum Massi, Nur Rahmansyah, Mirza Ariandi, Padlan Pasallo, and Ery Wildan. "Polymorphısm ın the inducıble nıtrıc oxıde synthase gene ınpatıent susceptıbılıty spınal tuberculosıs." International Journal of Medical Reviews and Case Reports 3.12 (2019), 819-822. Print. doi:10.5455/IJMRCR.spine-tuberculosis



APA (American Psychological Association) Style

Arifin, J., Biakto, . K. T., Usman, . A., Massi, . M. N., Rahmansyah, . N., Ariandi, . M., Pasallo, . P. & Wildan, . E. (2019) Polymorphısm ın the inducıble nıtrıc oxıde synthase gene ınpatıent susceptıbılıty spınal tuberculosıs. International Journal of Medical Reviews and Case Reports, 3 (12), 819-822. doi:10.5455/IJMRCR.spine-tuberculosis