E-ISSN 2534-9821
 

Review Article 


Tamsulosin and Dementia in old age: is there any relationship?

Rebecca Renata Lapenda do Monte, Karina de Andrade Vidal Costa, Arnaldo Santiago Nunes Junior, Am lia Cinthia Meneses R go, Irami Ara jo Filho.

Abstract
Tamsulosin is used to treat Benign Prostatic Hyperplasia (BPH), prescribed annually to about 12.6 million patients worldwide. It is an alpha-adrenergic antagonist that reduces the tone of the prostate smooth muscle involved in the pathophysiology of BPH. By acting on alpha 1A receptors, predominant in the prostate, tamsulosin also acts on receptors present in the brain. This study consisted of a literature review aimed at disseminating scientific knowledge about the relationship between the use of tamsulosin and the onset of dementia. Pubmed, Scopus, Scielo, Embase, and Web of Science studies involving dementia in patients using tamsulosin in the last five years were selected. The review showed a risk correlation and a higher incidence of dementia in treated patients. The risk ratio, when compared to other medicines, approached 1.20. In conclusion, it was identified the need for clinical trials with higher sampling power to increase relational significance due to the high prevalence of BPH and the extensive use of tamsulosin in elderly patients with the disease.

Key words: benign prostatic hyperplasia, prostatic hyperplasia, cognitive functions, tamsulosin, dementia, adrenergic alpha-1 receptor antagonists


 
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How to Cite this Article
Pubmed Style

Monte RRLd, Costa KdAV, Junior ASN, go AlCMR, Filho IAj, . Tamsulosin and Dementia in old age: is there any relationship?. Int J Med Rev Case Rep. 2019; 3(10): 632-635. doi:10.5455/IJMRCR.Tamsulosin-Dementia-in-old-age


Web Style

Monte RRLd, Costa KdAV, Junior ASN, go AlCMR, Filho IAj, . Tamsulosin and Dementia in old age: is there any relationship?. http://www.mdpub.net/?mno=62889 [Access: July 13, 2020]. doi:10.5455/IJMRCR.Tamsulosin-Dementia-in-old-age


AMA (American Medical Association) Style

Monte RRLd, Costa KdAV, Junior ASN, go AlCMR, Filho IAj, . Tamsulosin and Dementia in old age: is there any relationship?. Int J Med Rev Case Rep. 2019; 3(10): 632-635. doi:10.5455/IJMRCR.Tamsulosin-Dementia-in-old-age



Vancouver/ICMJE Style

Monte RRLd, Costa KdAV, Junior ASN, go AlCMR, Filho IAj, . Tamsulosin and Dementia in old age: is there any relationship?. Int J Med Rev Case Rep. (2019), [cited July 13, 2020]; 3(10): 632-635. doi:10.5455/IJMRCR.Tamsulosin-Dementia-in-old-age



Harvard Style

Monte, R. R. L. d., Costa, K. d. A. V., Junior, A. S. N., go, A. l. C. M. R., Filho, I. A. j. & (2019) Tamsulosin and Dementia in old age: is there any relationship?. Int J Med Rev Case Rep, 3 (10), 632-635. doi:10.5455/IJMRCR.Tamsulosin-Dementia-in-old-age



Turabian Style

Monte, Rebecca Renata Lapenda do, Karina de Andrade Vidal Costa, Arnaldo Santiago Nunes Junior, Am lia Cinthia Meneses R go, Irami Ara jo Filho, and . 2019. Tamsulosin and Dementia in old age: is there any relationship?. International Journal of Medical Reviews and Case Reports, 3 (10), 632-635. doi:10.5455/IJMRCR.Tamsulosin-Dementia-in-old-age



Chicago Style

Monte, Rebecca Renata Lapenda do, Karina de Andrade Vidal Costa, Arnaldo Santiago Nunes Junior, Am lia Cinthia Meneses R go, Irami Ara jo Filho, and . "Tamsulosin and Dementia in old age: is there any relationship?." International Journal of Medical Reviews and Case Reports 3 (2019), 632-635. doi:10.5455/IJMRCR.Tamsulosin-Dementia-in-old-age



MLA (The Modern Language Association) Style

Monte, Rebecca Renata Lapenda do, Karina de Andrade Vidal Costa, Arnaldo Santiago Nunes Junior, Am lia Cinthia Meneses R go, Irami Ara jo Filho, and . "Tamsulosin and Dementia in old age: is there any relationship?." International Journal of Medical Reviews and Case Reports 3.10 (2019), 632-635. Print. doi:10.5455/IJMRCR.Tamsulosin-Dementia-in-old-age



APA (American Psychological Association) Style

Monte, R. R. L. d., Costa, K. d. A. V., Junior, A. S. N., go, A. l. C. M. R., Filho, I. A. j. & (2019) Tamsulosin and Dementia in old age: is there any relationship?. International Journal of Medical Reviews and Case Reports, 3 (10), 632-635. doi:10.5455/IJMRCR.Tamsulosin-Dementia-in-old-age