E-ISSN 2534-9821
 

Case Report 


Effect of Methylphenidate on Blood Glucose Profile in an Adolescent Male with Type 1 Diabetes Mellitus: A Case Report

Khalid Abou Farha, Ramy Abou Farha.

Abstract
Introduction: Attention deficit/hyperactivity disorder (ADHD) is the commonest childhood neuro-developmental disorder. Methylphenidate (MPH) is a psychostimulant commonly prescribed in clinical practice to treat patients with ADHD. Comorbidity of Type 1Diabetes mellitus (T1D) and ADHD in children can be encountered in clinical practice. However, the impact of MPH on the blood glucose profile is scarcely addressed in the literature.
Methods: Multiple blood glucose concentrations (BGCs) obtained from a 12 years old male with T1D (under treatment with continuous insulin infusion) and comorbid ADHD have been evaluated after having received 2 dose levels (5 mg and 7.5 mg) methylphenidate (MPH). BGCs were assessed at 6 time points, over 3 weeks period. During the assessment periods, the patient had similar daily feeding en activity conditions and unchanged background insulin infusion The means of the values obtained after each dose level were compared with each other and with those obtained before commencement of MPH treatment.
Results: Three clinically relevant findings were encountered. The mean values of fasting Blood glucose levels (BGLs) obtained during MPH treatment periods were lower than that obtained before MPH use, respectively -28% and -23% below BL for the 5 and 7.5 mg dose levels. The means of other post-MPH treatment values obtained, through the day, were higher than that obtained before treatment, respectively +39% and +40% above Base line (BL). In addition, increasing MPH dose level was associated with increased BGL at all assessment time points.
Conclusion: Methylphenidate seems to dysregulate blood glucose levels in patients with type 1 diabetes mellitus. This might lead to serious consequences, including both microvascular and macrovascular diseases, particularly in vulnerable subjects such as those who receive medication for a long period of time. Commencement of treatment with and up-titration of MPH dose in ADHD patients with comorbid T1D requires close monitoring of blood glucose concentrations to avoid potential blood glucose excursions that might lead to unwanted complications.

Key words: Methylphenidate, ADHD, Type 1 Diabetes Mellitus


 
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How to Cite this Article
Pubmed Style

Farha KA, Farha RA. Effect of Methylphenidate on Blood Glucose Profile in an Adolescent Male with Type 1 Diabetes Mellitus: A Case Report. Int J Med Rev Case Rep. 2019; 3(11): 782-785. doi:10.5455/IJMRCR.Methylphenidate-in-type-1-Diabetes-mellitus


Web Style

Farha KA, Farha RA. Effect of Methylphenidate on Blood Glucose Profile in an Adolescent Male with Type 1 Diabetes Mellitus: A Case Report. http://www.mdpub.net/?mno=66809 [Access: January 26, 2020]. doi:10.5455/IJMRCR.Methylphenidate-in-type-1-Diabetes-mellitus


AMA (American Medical Association) Style

Farha KA, Farha RA. Effect of Methylphenidate on Blood Glucose Profile in an Adolescent Male with Type 1 Diabetes Mellitus: A Case Report. Int J Med Rev Case Rep. 2019; 3(11): 782-785. doi:10.5455/IJMRCR.Methylphenidate-in-type-1-Diabetes-mellitus



Vancouver/ICMJE Style

Farha KA, Farha RA. Effect of Methylphenidate on Blood Glucose Profile in an Adolescent Male with Type 1 Diabetes Mellitus: A Case Report. Int J Med Rev Case Rep. (2019), [cited January 26, 2020]; 3(11): 782-785. doi:10.5455/IJMRCR.Methylphenidate-in-type-1-Diabetes-mellitus



Harvard Style

Farha, K. A. & Farha, . R. A. (2019) Effect of Methylphenidate on Blood Glucose Profile in an Adolescent Male with Type 1 Diabetes Mellitus: A Case Report. Int J Med Rev Case Rep, 3 (11), 782-785. doi:10.5455/IJMRCR.Methylphenidate-in-type-1-Diabetes-mellitus



Turabian Style

Farha, Khalid Abou, and Ramy Abou Farha. 2019. Effect of Methylphenidate on Blood Glucose Profile in an Adolescent Male with Type 1 Diabetes Mellitus: A Case Report. International Journal of Medical Reviews and Case Reports, 3 (11), 782-785. doi:10.5455/IJMRCR.Methylphenidate-in-type-1-Diabetes-mellitus



Chicago Style

Farha, Khalid Abou, and Ramy Abou Farha. "Effect of Methylphenidate on Blood Glucose Profile in an Adolescent Male with Type 1 Diabetes Mellitus: A Case Report." International Journal of Medical Reviews and Case Reports 3 (2019), 782-785. doi:10.5455/IJMRCR.Methylphenidate-in-type-1-Diabetes-mellitus



MLA (The Modern Language Association) Style

Farha, Khalid Abou, and Ramy Abou Farha. "Effect of Methylphenidate on Blood Glucose Profile in an Adolescent Male with Type 1 Diabetes Mellitus: A Case Report." International Journal of Medical Reviews and Case Reports 3.11 (2019), 782-785. Print. doi:10.5455/IJMRCR.Methylphenidate-in-type-1-Diabetes-mellitus



APA (American Psychological Association) Style

Farha, K. A. & Farha, . R. A. (2019) Effect of Methylphenidate on Blood Glucose Profile in an Adolescent Male with Type 1 Diabetes Mellitus: A Case Report. International Journal of Medical Reviews and Case Reports, 3 (11), 782-785. doi:10.5455/IJMRCR.Methylphenidate-in-type-1-Diabetes-mellitus