E-ISSN 2534-9821
 

Original Research 


Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques

Ramazan Ícal, Nesrin Ícal.

Abstract
Background: While it is well known that systemic steroids may cause changes in hemogram parameters, it is important whether the use of inhaled corticosteroid (ICS) leads to changes in hemogram parameters. In this study, we aimed to find out the effects of ICSs on hemogram in comparison between different inhaler techniques of different corticosteroids.
Methods: The medical records of 100 ICS user COPD patients and 100 ICS non-user COPD patients were reviewed retrospectively. Demographic data, complete blood count values, GOLD groups, history of pneumonia in the last year, content of bronchodilator treatments and valid inhaler techniques were recorded.
Results: Significant increase was detected in the mean MCHC, Eosinophil%, #Eosinophil values among ICS non-users; and the mean RDW-CV, MCV, WBC, Neutrophil% and # Neutrophil values among ICS users (p<0.05). Anemia was observed in 16(%) of ICS non-users and 31(%) of ICS users (p=0.05). Fluticasone propionate group had the highest rate of pneumonia in the last year (11.1%) (p=0.05). WBC, Neutrophil%, #Neutrophil were significantly lower in budesonide group (p=0.012, p=0.05, p=0.048 respectively). The mean Monocyte% and #Monocyte were significantly lower in beclomethasone group (p=0.043, p=0.05, respectively). Nebulizer users had the highest frequency of pneumonia diagnosis in the last year (30%) (p=0.05). The mean WBC was significantly higher in blister-based DPI users (9.4´é▒2.3 x103cell/´üşL) (p=0.044). The frequency of pneumonia was increased by 3 fold/year in ICS users. Among the ICS users, the mean WBC and #Neutrophil values of these 9 patients were significantly higher than those without pneumonia history (10.8´é▒2.5 x103cell/´üşL and 6.3´é▒2.3 x103cell; p=0.042 and p=0.05, respectively).
Conclusion: The results of the study indicate that changes in hemogram parameters may be associated with ICS use and that these changes may be helpful in predicting systemic side effects of ICSs.

Key words: inhaled corticosteroid, side effect, hemogram, complete blood count, neutrophil


 
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Pubmed Style

Ocal R, Ocal N. Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques. Int J Med Rev Case Rep. 2019; 3(11): 684-692. doi:10.5455/IJMRCR.Alterations-hemogram-parameters-with-inhaled-corticosteroids


Web Style

Ocal R, Ocal N. Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques. http://www.mdpub.net/?mno=69507 [Access: January 26, 2020]. doi:10.5455/IJMRCR.Alterations-hemogram-parameters-with-inhaled-corticosteroids


AMA (American Medical Association) Style

Ocal R, Ocal N. Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques. Int J Med Rev Case Rep. 2019; 3(11): 684-692. doi:10.5455/IJMRCR.Alterations-hemogram-parameters-with-inhaled-corticosteroids



Vancouver/ICMJE Style

Ocal R, Ocal N. Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques. Int J Med Rev Case Rep. (2019), [cited January 26, 2020]; 3(11): 684-692. doi:10.5455/IJMRCR.Alterations-hemogram-parameters-with-inhaled-corticosteroids



Harvard Style

Ocal, R. & Ocal, . N. (2019) Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques. Int J Med Rev Case Rep, 3 (11), 684-692. doi:10.5455/IJMRCR.Alterations-hemogram-parameters-with-inhaled-corticosteroids



Turabian Style

Ocal, Ramazan, and Nesrin Ocal. 2019. Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques. International Journal of Medical Reviews and Case Reports, 3 (11), 684-692. doi:10.5455/IJMRCR.Alterations-hemogram-parameters-with-inhaled-corticosteroids



Chicago Style

Ocal, Ramazan, and Nesrin Ocal. "Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques." International Journal of Medical Reviews and Case Reports 3 (2019), 684-692. doi:10.5455/IJMRCR.Alterations-hemogram-parameters-with-inhaled-corticosteroids



MLA (The Modern Language Association) Style

Ocal, Ramazan, and Nesrin Ocal. "Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques." International Journal of Medical Reviews and Case Reports 3.11 (2019), 684-692. Print. doi:10.5455/IJMRCR.Alterations-hemogram-parameters-with-inhaled-corticosteroids



APA (American Psychological Association) Style

Ocal, R. & Ocal, . N. (2019) Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques. International Journal of Medical Reviews and Case Reports, 3 (11), 684-692. doi:10.5455/IJMRCR.Alterations-hemogram-parameters-with-inhaled-corticosteroids