E-ISSN 2534-9821
 

Original Research 


DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism is a higher Risk for Atopic Asthma

Harun Iskandar, Syakib Bakri, Budu Mannulusi, Ilham Jaya Patellongi.

Abstract
Background: Atopic asthma begins with exposure to allergens causing airway hyperresponsiveness and chronic inflammation. Angiotensin II involved in the pathogenesis of atopic asthma by causing airway hyperresponsiveness. Angiotensin II levels are influenced by the levels of ACE and ACE levels are influenced by I / D ACE gene polymorphisms. Study about the role of I/D ACE gene polymorphism in the incidence and severity of asthma in several countries and etnic showed inconsistency result. Study in Indonesian subjects had never been reported.
Method: This Case-control study aimed to evaluate influence of I/D ACE gene polymorphism in incidence and severity of atopic asthma. Eighty subjects aged 15-50 years including Forty non–asthmatic and Forty atopic asthmatic patients were included in this study..
Result: DD genotype with atopic asthma (85.7%) was higher than non atopic asthma (14,3%). Non-DD genotype (ID,II) with atopic asthma (46.6%) was lower than atopic asthma (53.4%). DD genotype of the ACE gene had risk 6.8 times to become atopic asthma than non-DD genotype (OR=6.8,p=0.05). DD genotype of ACE gene was not a risk factor for severe obstruction (OR=0.50, p=0.48) and uncontrolled atopic asthma compared to non-DD genotype (OR = 1.8,p=0.49)
Conclusions: This study concluded that DD genotype of ACE gene was a risk factor for the incidence of atopic asthma but not a risk factor for severe obstruction and uncontrolled atopic asthma.

Key words: Polymorphism, ACE gene, atopic asthma, severe obstruction, uncontrolled asthma


 
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How to Cite this Article
Pubmed Style

Iskandar H, Bakri S, Mannulusi B, Patellongi IJ. DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism is a higher Risk for Atopic Asthma. Int J Med Rev Case Rep. 2020; 4(5): 11-14. doi:10.5455/IJMRCR.atopic-asthma-ace-gene-polymorphism


Web Style

Iskandar H, Bakri S, Mannulusi B, Patellongi IJ. DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism is a higher Risk for Atopic Asthma. http://www.mdpub.net/?mno=73408 [Access: July 02, 2020]. doi:10.5455/IJMRCR.atopic-asthma-ace-gene-polymorphism


AMA (American Medical Association) Style

Iskandar H, Bakri S, Mannulusi B, Patellongi IJ. DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism is a higher Risk for Atopic Asthma. Int J Med Rev Case Rep. 2020; 4(5): 11-14. doi:10.5455/IJMRCR.atopic-asthma-ace-gene-polymorphism



Vancouver/ICMJE Style

Iskandar H, Bakri S, Mannulusi B, Patellongi IJ. DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism is a higher Risk for Atopic Asthma. Int J Med Rev Case Rep. (2020), [cited July 02, 2020]; 4(5): 11-14. doi:10.5455/IJMRCR.atopic-asthma-ace-gene-polymorphism



Harvard Style

Iskandar, H., Bakri, . S., Mannulusi, . B. & Patellongi, . I. J. (2020) DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism is a higher Risk for Atopic Asthma. Int J Med Rev Case Rep, 4 (5), 11-14. doi:10.5455/IJMRCR.atopic-asthma-ace-gene-polymorphism



Turabian Style

Iskandar, Harun, Syakib Bakri, Budu Mannulusi, and Ilham Jaya Patellongi. 2020. DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism is a higher Risk for Atopic Asthma. International Journal of Medical Reviews and Case Reports, 4 (5), 11-14. doi:10.5455/IJMRCR.atopic-asthma-ace-gene-polymorphism



Chicago Style

Iskandar, Harun, Syakib Bakri, Budu Mannulusi, and Ilham Jaya Patellongi. "DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism is a higher Risk for Atopic Asthma." International Journal of Medical Reviews and Case Reports 4 (2020), 11-14. doi:10.5455/IJMRCR.atopic-asthma-ace-gene-polymorphism



MLA (The Modern Language Association) Style

Iskandar, Harun, Syakib Bakri, Budu Mannulusi, and Ilham Jaya Patellongi. "DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism is a higher Risk for Atopic Asthma." International Journal of Medical Reviews and Case Reports 4.5 (2020), 11-14. Print. doi:10.5455/IJMRCR.atopic-asthma-ace-gene-polymorphism



APA (American Psychological Association) Style

Iskandar, H., Bakri, . S., Mannulusi, . B. & Patellongi, . I. J. (2020) DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism is a higher Risk for Atopic Asthma. International Journal of Medical Reviews and Case Reports, 4 (5), 11-14. doi:10.5455/IJMRCR.atopic-asthma-ace-gene-polymorphism