Abstract
Backround: Systemic Lupus Erythematosus (SLE) is an autoimmune rheumatic disease characterized by inflammation that affects the organs or systems in the body. This disease is associated with the deposit of autoantibodies and immune complexes which caused a tissue damage. Clinical manifestations of SLE are very vast, including the involvement of skin and mucosa, joints, blood, heart, lung, kidney, central nervous system (CNS), and the immune system. Lymphocytes is one type of white blood cell (leucocyte) which play a role in the pathogenesis of SLE through the role of B cells and T cells. Lymphocyte levels are also included in hematologic criteria of SLE patients, and are also used as a parameter to measure the activity degree of SLE disease. Lymphopenia in patients with SLE is associated with the increase of organ damage index.
Objective: To determine the level of lymphocyte in various clinical manifestations of patients with SLE.
Methods: This study was an analytic research with cross-sectional design. The study subjects were all newly diagnosed patients with SLE. The study was conducted at Wahidin Sudirohusodo Hospital and its network during February until June 2018.
Results: Subjects who met the study criteria were 37 who were all female. The lowest lymphocyte level was 133μl and the highest was 3978μl with an average level 1244.6μl. The most comon clinical manifestations were mucocutaneous with 26 subjects (97.3%). Clinical manifestations of renal disorders (p <0.001), vasculitis (p = 0.003) and constitutional symptoms (p = 0.002) had more significant relationship in patients with lymphopenia compared to patients who had a normal lymphocyte levels (p <0.01). Subjects with >3 clinical manifestations had an average lymphocyte levels 1018.03ul, while the subjects with ≤ 3 clinical manifestations had an average lymphocyte level of 1949.44 This result was statistically significant, with p = <0.001.
Conclusions: Renal manifestations and vasculitis increase in subjects with lymphopenia. Lympophenia is commonly found in subjects who have more clinical manifestations.

Key words: SLE, lymphocyte level, clinical manifestation