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Original Research
Online Published: 04 Mar 2020
 


The Role of Inflammation in Pathogenesis of Preeclampsia: An Investigation of interleukin-6, interleukin 10, and the Ratio

Dewi Setiawati.


Abstract
Introduction: Pre-eclampsia is a major cause of maternal mortality and morbidity, preterm birth, perinatal death, and intrauterine growth restriction in global maternity cases.
Purpose: The study aims to investigate the role of pro-inflammatory and anti-inflammatory cytokines in the pathophysiology of preeclampsia.
Method: In order to get cross sectional data, The study employed observation method. The serum IL-6 and IL-10 of the subjects with preeclampsia and normal pregnancies were measured. The systolic, diastolic blood pressures, and proteinuria of the subjects were also checked. The results were evaluated using the t-test, the Kruskal-Wallis test, and the Spearman correlation test (P<0.05)
Results: Twenty subjects with severe preeclampsia, 15 subjects with mild preeclampsia, and 35 subjects with normal pregnancies were examined by taking blood sampling. The serum IL-6, IL-6:IL-10 ratio were significantly different between those groups, but IL-10 was not. The serum IL-6 and IL-6:IL-10 ratios were significantly correlated with the systolic, diastolic blood pressure, and proteinuria level. It indicates that pro-inflammatory cytokine (IL-6) has a role in the pathogenesis of preeclampsia.
Conclusion: Pro-inflammatory cytokine (IL-6) has a role in pathogenesis in preeclampsia, but not anti-inflammmatory cytokine (IL-10.

Key words: Preeclampsia, interleukin-6, interleukin-10, inflammation, pathogenesis


 
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Pubmed Style

Dewi Setiawati. The Role of Inflammation in Pathogenesis of Preeclampsia: An Investigation of interleukin-6, interleukin 10, and the Ratio. Int J Med Rev Case Rep. 2020; 4(10): 13-17. doi:10.5455/IJMRCR.pathogenesis-preeclampsia-inflammation

Web Style

Dewi Setiawati. The Role of Inflammation in Pathogenesis of Preeclampsia: An Investigation of interleukin-6, interleukin 10, and the Ratio. https://www.mdpub.net/?mno=85230 [Access: October 13, 2024]. doi:10.5455/IJMRCR.pathogenesis-preeclampsia-inflammation

AMA (American Medical Association) Style

Dewi Setiawati. The Role of Inflammation in Pathogenesis of Preeclampsia: An Investigation of interleukin-6, interleukin 10, and the Ratio. Int J Med Rev Case Rep. 2020; 4(10): 13-17. doi:10.5455/IJMRCR.pathogenesis-preeclampsia-inflammation


Vancouver/ICMJE Style

Dewi Setiawati. The Role of Inflammation in Pathogenesis of Preeclampsia: An Investigation of interleukin-6, interleukin 10, and the Ratio. Int J Med Rev Case Rep. (2020), [cited October 13, 2024]; 4(10): 13-17. doi:10.5455/IJMRCR.pathogenesis-preeclampsia-inflammation


Harvard Style

Dewi Setiawati (2020) The Role of Inflammation in Pathogenesis of Preeclampsia: An Investigation of interleukin-6, interleukin 10, and the Ratio. Int J Med Rev Case Rep, 4 (10), 13-17. doi:10.5455/IJMRCR.pathogenesis-preeclampsia-inflammation


Turabian Style

Dewi Setiawati. 2020. The Role of Inflammation in Pathogenesis of Preeclampsia: An Investigation of interleukin-6, interleukin 10, and the Ratio. International Journal of Medical Reviews and Case Reports, 4 (10), 13-17. doi:10.5455/IJMRCR.pathogenesis-preeclampsia-inflammation


Chicago Style

Dewi Setiawati. "The Role of Inflammation in Pathogenesis of Preeclampsia: An Investigation of interleukin-6, interleukin 10, and the Ratio." International Journal of Medical Reviews and Case Reports 4 (2020), 13-17. doi:10.5455/IJMRCR.pathogenesis-preeclampsia-inflammation


MLA (The Modern Language Association) Style

Dewi Setiawati. "The Role of Inflammation in Pathogenesis of Preeclampsia: An Investigation of interleukin-6, interleukin 10, and the Ratio." International Journal of Medical Reviews and Case Reports 4.10 (2020), 13-17. Print. doi:10.5455/IJMRCR.pathogenesis-preeclampsia-inflammation


APA (American Psychological Association) Style

Dewi Setiawati (2020) The Role of Inflammation in Pathogenesis of Preeclampsia: An Investigation of interleukin-6, interleukin 10, and the Ratio. International Journal of Medical Reviews and Case Reports, 4 (10), 13-17. doi:10.5455/IJMRCR.pathogenesis-preeclampsia-inflammation


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