E-ISSN 2534-9821
 

Original Research 


Effects of l-glutamine supplementation on reducing c-reactive protein (CRP) levels and length of stay in intensive care unit post laparotomy

Daniel, Pontisomaya Parami.

Abstract
Backgrounds: Post-laparotomy ICU patients have an average length of stay in the ICU with an average of 7-14 days depending on the procedure and postoperative complications. When the body is sick or injured, glutamine will become "conditionally-essential" which is a condition where a person needs additional food or supplements. Glutamine (Gln) has been shown to have an important function for various organ systems, including the intestines, the immune system, and to maintain acid-base balance. C-reactive protein (CRP) is a sensitive inflammatory marker to assess non-specific inflammatory response and there is an inverse relationship between Gln and CRP levels (r = -0.44, p < 0.05).
Aims: L-Glutamin 20 gram intravenous per day for 3 days can reduce CRP levels and length of stay in ICU of the post-laparotomy patients.
Method: This study used a double-blind randomized clinical trial to compare a group with L-Gln supplementation and without L-Gln supplementation, for laparotomy patients who were treated in the ICU from March to June 2021.
Results: There were 40 patients divided into 2 groups. The statistical analysis results found the difference in CRP levels, p-value <0.001 and length of stay in ICU, p-value 0.011. Length of stay in the ICU of patients with high CRP was positively related with a significant correlation, r = 0.372 p = 0.018
Conclusion: L-Glutamin 20 gram intravenous per day for 3 days can reduce CRP levels and length of stay at ICU for post laparotomy patients.

Key words: C-reactive protein, Glutamine, Intensive care unit, length of stay, laparotomy


 
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Pubmed Style

, Parami P. Effects of l-glutamine supplementation on reducing c-reactive protein (CRP) levels and length of stay in intensive care unit post laparotomy. Int J Med Rev Case Rep. 2021; 5(13): 20-23. doi:10.5455/IJMRCR.l-glutamin-crp-levels-postlaparotomy


Web Style

, Parami P. Effects of l-glutamine supplementation on reducing c-reactive protein (CRP) levels and length of stay in intensive care unit post laparotomy. http://www.mdpub.net/?mno=101231 [Access: December 31, 2021]. doi:10.5455/IJMRCR.l-glutamin-crp-levels-postlaparotomy


AMA (American Medical Association) Style

, Parami P. Effects of l-glutamine supplementation on reducing c-reactive protein (CRP) levels and length of stay in intensive care unit post laparotomy. Int J Med Rev Case Rep. 2021; 5(13): 20-23. doi:10.5455/IJMRCR.l-glutamin-crp-levels-postlaparotomy



Vancouver/ICMJE Style

, Parami P. Effects of l-glutamine supplementation on reducing c-reactive protein (CRP) levels and length of stay in intensive care unit post laparotomy. Int J Med Rev Case Rep. (2021), [cited December 31, 2021]; 5(13): 20-23. doi:10.5455/IJMRCR.l-glutamin-crp-levels-postlaparotomy



Harvard Style

& Parami, . P. (2021) Effects of l-glutamine supplementation on reducing c-reactive protein (CRP) levels and length of stay in intensive care unit post laparotomy. Int J Med Rev Case Rep, 5 (13), 20-23. doi:10.5455/IJMRCR.l-glutamin-crp-levels-postlaparotomy



Turabian Style

, and Pontisomaya Parami. 2021. Effects of l-glutamine supplementation on reducing c-reactive protein (CRP) levels and length of stay in intensive care unit post laparotomy. International Journal of Medical Reviews and Case Reports, 5 (13), 20-23. doi:10.5455/IJMRCR.l-glutamin-crp-levels-postlaparotomy



Chicago Style

, and Pontisomaya Parami. "Effects of l-glutamine supplementation on reducing c-reactive protein (CRP) levels and length of stay in intensive care unit post laparotomy." International Journal of Medical Reviews and Case Reports 5 (2021), 20-23. doi:10.5455/IJMRCR.l-glutamin-crp-levels-postlaparotomy



MLA (The Modern Language Association) Style

, and Pontisomaya Parami. "Effects of l-glutamine supplementation on reducing c-reactive protein (CRP) levels and length of stay in intensive care unit post laparotomy." International Journal of Medical Reviews and Case Reports 5.13 (2021), 20-23. Print. doi:10.5455/IJMRCR.l-glutamin-crp-levels-postlaparotomy



APA (American Psychological Association) Style

& Parami, . P. (2021) Effects of l-glutamine supplementation on reducing c-reactive protein (CRP) levels and length of stay in intensive care unit post laparotomy. International Journal of Medical Reviews and Case Reports, 5 (13), 20-23. doi:10.5455/IJMRCR.l-glutamin-crp-levels-postlaparotomy