E-ISSN 2534-9821
 

Case Report 


Fibroblast growth factor: A target for covid-19 infection

Pedro Cuevas, Antonio Manquillo, Pedro Guillen, Guillermo GIménez-Gallego.

Abstract
In the last few months, covid-19 has spread as a highly contagious pandemic. Currently no therapies have proven to be effective for the treatment of this severe illness that progresses with a strong inflammation in different organs and systems. Because fibroblast growth factor (FGF) is a potent inflammatory agent, we have tested, in one patient who didn’t respond to the protocol therapy, the effect of FGF inhibition with an anti-inflammatory and antiviral compound with a large history of medical use which was reported as the most effective anti-FGF inhibitor: dobesilate. After five days of oral treatment, dobesilate resulted in amelioration of chest radiographies as well as in clinical improvement, opening a new possible therapeutic mean to be tested in patients.

Key words: Covid-19 infection, fibroblast growth factor, dobesilate


 
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How to Cite this Article
Pubmed Style

Pedro Cuevas| Antonio Manquillo| Pedro Guillen| Guillermo GIménez-Gallego. Fibroblast growth factor: A target for covid-19 infection. Int J Med Rev Case Rep. 2020; 4(5): 122-125. doi:10.5455/IJMRCR.Fibroblast-growth-factor-COVID-19


Web Style

Pedro Cuevas| Antonio Manquillo| Pedro Guillen| Guillermo GIménez-Gallego. Fibroblast growth factor: A target for covid-19 infection. http://www.mdpub.net/?mno=103656 [Access: July 15, 2020]. doi:10.5455/IJMRCR.Fibroblast-growth-factor-COVID-19


AMA (American Medical Association) Style

Pedro Cuevas| Antonio Manquillo| Pedro Guillen| Guillermo GIménez-Gallego. Fibroblast growth factor: A target for covid-19 infection. Int J Med Rev Case Rep. 2020; 4(5): 122-125. doi:10.5455/IJMRCR.Fibroblast-growth-factor-COVID-19



Vancouver/ICMJE Style

Pedro Cuevas| Antonio Manquillo| Pedro Guillen| Guillermo GIménez-Gallego. Fibroblast growth factor: A target for covid-19 infection. Int J Med Rev Case Rep. (2020), [cited July 15, 2020]; 4(5): 122-125. doi:10.5455/IJMRCR.Fibroblast-growth-factor-COVID-19



Harvard Style

Pedro Cuevas| Antonio Manquillo| Pedro Guillen| Guillermo GIménez-Gallego (2020) Fibroblast growth factor: A target for covid-19 infection. Int J Med Rev Case Rep, 4 (5), 122-125. doi:10.5455/IJMRCR.Fibroblast-growth-factor-COVID-19



Turabian Style

Pedro Cuevas| Antonio Manquillo| Pedro Guillen| Guillermo GIménez-Gallego. 2020. Fibroblast growth factor: A target for covid-19 infection. International Journal of Medical Reviews and Case Reports, 4 (5), 122-125. doi:10.5455/IJMRCR.Fibroblast-growth-factor-COVID-19



Chicago Style

Pedro Cuevas| Antonio Manquillo| Pedro Guillen| Guillermo GIménez-Gallego. "Fibroblast growth factor: A target for covid-19 infection." International Journal of Medical Reviews and Case Reports 4 (2020), 122-125. doi:10.5455/IJMRCR.Fibroblast-growth-factor-COVID-19



MLA (The Modern Language Association) Style

Pedro Cuevas| Antonio Manquillo| Pedro Guillen| Guillermo GIménez-Gallego. "Fibroblast growth factor: A target for covid-19 infection." International Journal of Medical Reviews and Case Reports 4.5 (2020), 122-125. Print. doi:10.5455/IJMRCR.Fibroblast-growth-factor-COVID-19



APA (American Psychological Association) Style

Pedro Cuevas| Antonio Manquillo| Pedro Guillen| Guillermo GIménez-Gallego (2020) Fibroblast growth factor: A target for covid-19 infection. International Journal of Medical Reviews and Case Reports, 4 (5), 122-125. doi:10.5455/IJMRCR.Fibroblast-growth-factor-COVID-19