E-ISSN 2534-9821
 

Case Report 


Acute bilateral Proptosis and ophthalmoplegia as Isolated Ocular manifestation of accelerated phase chronic myeloid leukaemia on Nilotinib

Manzoor Khan, Mussadique Ali, Chandumal Lohana, Bushra Ahsan, Usman Ahmad, Syed Waqas Bokhari.

Abstract
Chronic myeloid leukaemia (CML) is a myeloproliferative neoplasm characterized by Philadelphia chromosome with excessive tyrosine activity leading to uncontrolled proliferation of mature and maturing granulocytes, predominantly neutrophils. If left untreated CML goes though chronic phase, accelerated phase and ultimately Blast Crises. Accelerated phase is characterized by features of disease progression without meeting criteria for chronic phase or blast crises. We present a case of young male with CML who presented with acute bilateral proptosis and rapidly rising white cell count. On work up he was found to have progressed to accelerated phase of CML on the basis of rapidly rising WCC and clonal evolution with new cytogenetic finding of 3q deletion in Philadelphia positive cells. He was treated with high dose Cytarabine with complete resolution of proptosis and hematologic remission.

Key words: CML, Clonal Evolution, Accelerated Phase


 
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How to Cite this Article
Pubmed Style

Khan M, Ali M, Lohana C, Ahsan B, Ahmad U, Bokhari SW. Acute bilateral Proptosis and ophthalmoplegia as Isolated Ocular manifestation of accelerated phase chronic myeloid leukaemia on Nilotinib. Int J Med Rev Case Rep. 2020; 4(12): 50-52. doi:10.5455/IJMRCR.Acute-bilateral-Proptosis-ophthalmoplegia-case


Web Style

Khan M, Ali M, Lohana C, Ahsan B, Ahmad U, Bokhari SW. Acute bilateral Proptosis and ophthalmoplegia as Isolated Ocular manifestation of accelerated phase chronic myeloid leukaemia on Nilotinib. http://www.mdpub.net/?mno=104428 [Access: January 10, 2021]. doi:10.5455/IJMRCR.Acute-bilateral-Proptosis-ophthalmoplegia-case


AMA (American Medical Association) Style

Khan M, Ali M, Lohana C, Ahsan B, Ahmad U, Bokhari SW. Acute bilateral Proptosis and ophthalmoplegia as Isolated Ocular manifestation of accelerated phase chronic myeloid leukaemia on Nilotinib. Int J Med Rev Case Rep. 2020; 4(12): 50-52. doi:10.5455/IJMRCR.Acute-bilateral-Proptosis-ophthalmoplegia-case



Vancouver/ICMJE Style

Khan M, Ali M, Lohana C, Ahsan B, Ahmad U, Bokhari SW. Acute bilateral Proptosis and ophthalmoplegia as Isolated Ocular manifestation of accelerated phase chronic myeloid leukaemia on Nilotinib. Int J Med Rev Case Rep. (2020), [cited January 10, 2021]; 4(12): 50-52. doi:10.5455/IJMRCR.Acute-bilateral-Proptosis-ophthalmoplegia-case



Harvard Style

Khan, M., Ali, . M., Lohana, . C., Ahsan, . B., Ahmad, . U. & Bokhari, . S. W. (2020) Acute bilateral Proptosis and ophthalmoplegia as Isolated Ocular manifestation of accelerated phase chronic myeloid leukaemia on Nilotinib. Int J Med Rev Case Rep, 4 (12), 50-52. doi:10.5455/IJMRCR.Acute-bilateral-Proptosis-ophthalmoplegia-case



Turabian Style

Khan, Manzoor, Mussadique Ali, Chandumal Lohana, Bushra Ahsan, Usman Ahmad, and Syed Waqas Bokhari. 2020. Acute bilateral Proptosis and ophthalmoplegia as Isolated Ocular manifestation of accelerated phase chronic myeloid leukaemia on Nilotinib. International Journal of Medical Reviews and Case Reports, 4 (12), 50-52. doi:10.5455/IJMRCR.Acute-bilateral-Proptosis-ophthalmoplegia-case



Chicago Style

Khan, Manzoor, Mussadique Ali, Chandumal Lohana, Bushra Ahsan, Usman Ahmad, and Syed Waqas Bokhari. "Acute bilateral Proptosis and ophthalmoplegia as Isolated Ocular manifestation of accelerated phase chronic myeloid leukaemia on Nilotinib." International Journal of Medical Reviews and Case Reports 4 (2020), 50-52. doi:10.5455/IJMRCR.Acute-bilateral-Proptosis-ophthalmoplegia-case



MLA (The Modern Language Association) Style

Khan, Manzoor, Mussadique Ali, Chandumal Lohana, Bushra Ahsan, Usman Ahmad, and Syed Waqas Bokhari. "Acute bilateral Proptosis and ophthalmoplegia as Isolated Ocular manifestation of accelerated phase chronic myeloid leukaemia on Nilotinib." International Journal of Medical Reviews and Case Reports 4.12 (2020), 50-52. Print. doi:10.5455/IJMRCR.Acute-bilateral-Proptosis-ophthalmoplegia-case



APA (American Psychological Association) Style

Khan, M., Ali, . M., Lohana, . C., Ahsan, . B., Ahmad, . U. & Bokhari, . S. W. (2020) Acute bilateral Proptosis and ophthalmoplegia as Isolated Ocular manifestation of accelerated phase chronic myeloid leukaemia on Nilotinib. International Journal of Medical Reviews and Case Reports, 4 (12), 50-52. doi:10.5455/IJMRCR.Acute-bilateral-Proptosis-ophthalmoplegia-case