E-ISSN 2534-9821
 

Original Research 


Effect of virgin coconut oil on the kidney of wistar rats exposed to toxic dose of paraquat

Joseph Nwafor, Joy Umudu, Augustine Oviosun, Obinna Uchewa.

Abstract
Background and objective: Paraquat toxicity to bodily organs is a public health concern, especially in climes where there no safe remedies. This study investigated the effect of Virgin Coconut Oil (VCO) on the kidney of wistar rats exposed to toxic dose of paraquat. Materials and Methods: Four groups (A, B, C and D) of six adult wistar rats were used. Group A is the normal control. Group B rats received oral dose of 12.75mg/kg b.wt of paraquat without treatment. Groups C and D were pre-treated respectively with 5 and 10 ml/kg b.w.t of VCO before exposure to paraquat. The experiment lasted for 24 days. At the end of administration, the rats were sacrificed. The kidney was harvested for routine histology and blood was collected via cardiac puncture for biochemical analysis. Results: Group B had a significant (p≤0.05) increase in mean values of potassium (5.41±0.16), urea (5.15±0.07), creatinine (59.00±8.34) and MDA (2.94±0.07) levels when compared to group A. Group D shows a significant (p≤0.05) decrease in these parameters. Except for potassium, group C also showed a decrease in the afore mentioned parameters when compared to group B. In comparison to groups B and D, C had a significant decrease in SOD (4.85±2.05). VCO preserved the kidney cortex. Conclusion: The finding of this study has shown that the toxic effects of paraquat on kidney function could be moderately reversed by phyto-oxidants present in virgin coconut oil. Thus, virgin coconut oil has anti-oxidative and nephroprotective benefits against paraquat nephrotoxicity. However, this may be dose dependent.

Key words: Paraquat, Virgin Coconut Oil, Kidney, Toxicity


 
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How to Cite this Article
Pubmed Style

Nwafor J, Umudu J, Oviosun A, Uchewa O. Effect of virgin coconut oil on the kidney of wistar rats exposed to toxic dose of paraquat. Int J Med Rev Case Rep. 2020; 4(5): 136-140. doi:10.5455/IJMRCR.virgin-coconut-oil-the-kidney-wistar-rats


Web Style

Nwafor J, Umudu J, Oviosun A, Uchewa O. Effect of virgin coconut oil on the kidney of wistar rats exposed to toxic dose of paraquat. http://www.mdpub.net/?mno=85819 [Access: July 15, 2020]. doi:10.5455/IJMRCR.virgin-coconut-oil-the-kidney-wistar-rats


AMA (American Medical Association) Style

Nwafor J, Umudu J, Oviosun A, Uchewa O. Effect of virgin coconut oil on the kidney of wistar rats exposed to toxic dose of paraquat. Int J Med Rev Case Rep. 2020; 4(5): 136-140. doi:10.5455/IJMRCR.virgin-coconut-oil-the-kidney-wistar-rats



Vancouver/ICMJE Style

Nwafor J, Umudu J, Oviosun A, Uchewa O. Effect of virgin coconut oil on the kidney of wistar rats exposed to toxic dose of paraquat. Int J Med Rev Case Rep. (2020), [cited July 15, 2020]; 4(5): 136-140. doi:10.5455/IJMRCR.virgin-coconut-oil-the-kidney-wistar-rats



Harvard Style

Nwafor, J., Umudu, . J., Oviosun, . A. & Uchewa, . O. (2020) Effect of virgin coconut oil on the kidney of wistar rats exposed to toxic dose of paraquat. Int J Med Rev Case Rep, 4 (5), 136-140. doi:10.5455/IJMRCR.virgin-coconut-oil-the-kidney-wistar-rats



Turabian Style

Nwafor, Joseph, Joy Umudu, Augustine Oviosun, and Obinna Uchewa. 2020. Effect of virgin coconut oil on the kidney of wistar rats exposed to toxic dose of paraquat. International Journal of Medical Reviews and Case Reports, 4 (5), 136-140. doi:10.5455/IJMRCR.virgin-coconut-oil-the-kidney-wistar-rats



Chicago Style

Nwafor, Joseph, Joy Umudu, Augustine Oviosun, and Obinna Uchewa. "Effect of virgin coconut oil on the kidney of wistar rats exposed to toxic dose of paraquat." International Journal of Medical Reviews and Case Reports 4 (2020), 136-140. doi:10.5455/IJMRCR.virgin-coconut-oil-the-kidney-wistar-rats



MLA (The Modern Language Association) Style

Nwafor, Joseph, Joy Umudu, Augustine Oviosun, and Obinna Uchewa. "Effect of virgin coconut oil on the kidney of wistar rats exposed to toxic dose of paraquat." International Journal of Medical Reviews and Case Reports 4.5 (2020), 136-140. Print. doi:10.5455/IJMRCR.virgin-coconut-oil-the-kidney-wistar-rats



APA (American Psychological Association) Style

Nwafor, J., Umudu, . J., Oviosun, . A. & Uchewa, . O. (2020) Effect of virgin coconut oil on the kidney of wistar rats exposed to toxic dose of paraquat. International Journal of Medical Reviews and Case Reports, 4 (5), 136-140. doi:10.5455/IJMRCR.virgin-coconut-oil-the-kidney-wistar-rats