E-ISSN 2534-9821
 

Review Article 


THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN

Pascanus LP Togatorop, Faldi Yaputra, Jimmy FA Barus, I Putu Eka Widyadharma.

Abstract
Neuropathic pain (NP) is a pain caused by lesions in the nervous system. Several causes of NP are traumatic, metabolic disorders, ischemia, toxins, infections, immune-related, and hereditary. The pathophysiology of NP is very complicated and unknown entirely. Therefore the treatment of NP is still unsatisfactory. Recent studies believed the critical role of primary inflammatory mediators in the pathophysiology of NP especially leukotrienes (LTs). The 5-lipoxygenase enzyme (5-LOX) is an enzyme that plays a role in the metabolism of arachidonic acid into LTs. Leukotrienes (LTs) are the essential inflammatory mediators in the pathophysiology of NP. Leukotriene B4 (LTB4) can cause chemotaxis on neutrophils, lowering nociceptors threshold and may contribute to NP. Several studies believed the administration of 5-LOX inhibitors or LTs receptor antagonists could be useful in the management of NP. The purpose of this review is to summarize the involvement of 5-LOX enzyme as an essential role in the pathophysiology and management of NP.

Key words: 5-lipoxygenase, leukotrienes, pathophysiology of neuropathic pain, inflammatory mediators, management of neuropathic pain


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Pascanus LP Togatorop
Articles by Faldi Yaputra
Articles by Jimmy FA Barus
Articles by I Putu Eka Widyadharma
on Google
on Google Scholar
Article Statistics
 Viewed: 350
Downloaded:
Cited: 0

How to Cite this Article
Pubmed Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE, . THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep. 2018; 2(3): 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN


Web Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE, . THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. http://mdpub.net/?mno=2428 [Access: December 19, 2018]. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN


AMA (American Medical Association) Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE, . THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep. 2018; 2(3): 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN



Vancouver/ICMJE Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE, . THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep. (2018), [cited December 19, 2018]; 2(3): 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN



Harvard Style

Togatorop, P. L., Yaputra, F. ., Barus, J. F., Widyadharma, I. P. . E. & (2018) THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep, 2 (3), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN



Turabian Style

Togatorop, Pascanus LP, Faldi Yaputra, Jimmy FA Barus, I Putu Eka Widyadharma, and . 2018. THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. International Journal of Medical Reviews and Case Reports, 2 (3), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN



Chicago Style

Togatorop, Pascanus LP, Faldi Yaputra, Jimmy FA Barus, I Putu Eka Widyadharma, and . "THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN." International Journal of Medical Reviews and Case Reports 2 (2018), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN



MLA (The Modern Language Association) Style

Togatorop, Pascanus LP, Faldi Yaputra, Jimmy FA Barus, I Putu Eka Widyadharma, and . "THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN." International Journal of Medical Reviews and Case Reports 2.3 (2018), 58-61. Print. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN



APA (American Psychological Association) Style

Togatorop, P. L., Yaputra, F. ., Barus, J. F., Widyadharma, I. P. . E. & (2018) THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. International Journal of Medical Reviews and Case Reports, 2 (3), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN