E-ISSN 2534-9821
 

Review Article 


Dobesilate an old drug as a possible new treatment option for COVID-19 infection

Pedro Cuevas, Javier Angulo, Daniel Zingg, Antonio Manquillo, José Luis Calleja, Guillermo Giménez-Gallego.

Abstract
COVID-19 pandemic is responsible for near to two million deaths worldwide. Because of the lack of any specific treatment option, repurposing of existing drugs continues worldwide in order to find immediate therapeutic strategies for deadly SARS-CoV-2 infection. We recently demonstrated the efficacy of Dobesilate, an old medicament with a long history of use with proven efficacy and good safety profiles, in a patient suffering from COVID-19 disease. The postulated therapeutic mechanism of Dobesilate in COVID-19 disease may primarily involve the following effects: reducing infection-related pathways, suppressing inflammation-related pathways (cytokine storm), protecting capillary barrier permeability, alleviating thrombosis and perivascular oedema, and ultimately attenuating interstitial fibrosis.

Key words: SARS-CoV-2, COVID-19, Dobesilate, FGF, VEGF


 
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How to Cite this Article
Pubmed Style

Pedro Cuevas| Javier Angulo| Daniel Zingg| Antonio Manquillo| José Luis Calleja| Guillermo Giménez-Gallego. Dobesilate an old drug as a possible new treatment option for COVID-19 infection. Int J Med Rev Case Rep. 2021; 5(5): 113-121. doi:10.5455/IJMRCR.dobesilate-covid-19


Web Style

Pedro Cuevas| Javier Angulo| Daniel Zingg| Antonio Manquillo| José Luis Calleja| Guillermo Giménez-Gallego. Dobesilate an old drug as a possible new treatment option for COVID-19 infection. http://www.mdpub.net/?mno=85175 [Access: December 31, 2021]. doi:10.5455/IJMRCR.dobesilate-covid-19


AMA (American Medical Association) Style

Pedro Cuevas| Javier Angulo| Daniel Zingg| Antonio Manquillo| José Luis Calleja| Guillermo Giménez-Gallego. Dobesilate an old drug as a possible new treatment option for COVID-19 infection. Int J Med Rev Case Rep. 2021; 5(5): 113-121. doi:10.5455/IJMRCR.dobesilate-covid-19



Vancouver/ICMJE Style

Pedro Cuevas| Javier Angulo| Daniel Zingg| Antonio Manquillo| José Luis Calleja| Guillermo Giménez-Gallego. Dobesilate an old drug as a possible new treatment option for COVID-19 infection. Int J Med Rev Case Rep. (2021), [cited December 31, 2021]; 5(5): 113-121. doi:10.5455/IJMRCR.dobesilate-covid-19



Harvard Style

Pedro Cuevas| Javier Angulo| Daniel Zingg| Antonio Manquillo| José Luis Calleja| Guillermo Giménez-Gallego (2021) Dobesilate an old drug as a possible new treatment option for COVID-19 infection. Int J Med Rev Case Rep, 5 (5), 113-121. doi:10.5455/IJMRCR.dobesilate-covid-19



Turabian Style

Pedro Cuevas| Javier Angulo| Daniel Zingg| Antonio Manquillo| José Luis Calleja| Guillermo Giménez-Gallego. 2021. Dobesilate an old drug as a possible new treatment option for COVID-19 infection. International Journal of Medical Reviews and Case Reports, 5 (5), 113-121. doi:10.5455/IJMRCR.dobesilate-covid-19



Chicago Style

Pedro Cuevas| Javier Angulo| Daniel Zingg| Antonio Manquillo| José Luis Calleja| Guillermo Giménez-Gallego. "Dobesilate an old drug as a possible new treatment option for COVID-19 infection." International Journal of Medical Reviews and Case Reports 5 (2021), 113-121. doi:10.5455/IJMRCR.dobesilate-covid-19



MLA (The Modern Language Association) Style

Pedro Cuevas| Javier Angulo| Daniel Zingg| Antonio Manquillo| José Luis Calleja| Guillermo Giménez-Gallego. "Dobesilate an old drug as a possible new treatment option for COVID-19 infection." International Journal of Medical Reviews and Case Reports 5.5 (2021), 113-121. Print. doi:10.5455/IJMRCR.dobesilate-covid-19



APA (American Psychological Association) Style

Pedro Cuevas| Javier Angulo| Daniel Zingg| Antonio Manquillo| José Luis Calleja| Guillermo Giménez-Gallego (2021) Dobesilate an old drug as a possible new treatment option for COVID-19 infection. International Journal of Medical Reviews and Case Reports, 5 (5), 113-121. doi:10.5455/IJMRCR.dobesilate-covid-19