E-ISSN 2534-9821
 

Case Report 


A case of a periosteal reaction in a patient with paroxysmal nocturnal haemoglobinuria newly diagnosed with acute myeloid leukaemia: A South African perspective

Garrick Laudin, Peter Levay, Gugulethu Ndhlebe.

Abstract
Paroxysmal nocturnal haemoglobinuria is an orphan disease and is a deficiency in more than one GPI-linked protein on red cells which makes them vulnerable to complement mediated lysis. The availability of treatment for PNH in the form of eculizumab is currently not available in resource poor countries such as South Africa. The rare clinical manifestation of a periosteal bone reaction and upper limb swelling in a 28year-old male patient with an established diagnosis of PNH prompted exclusion of infectious and thrombotic causes for the presumed periostitis and swollen limb. Confounders in this case were the presence of splenomegaly a rare finding in PNH. Further examinations of haematological parameters revealed the presence of blasts with flow cytometry confirming an acute myeloid leukaemia.

Key words: Leukaemia, Acute Myeloid Leukaemia, Paroxysmal Nocturnal Haemoglobinuria, periosteal reaction, Rheumatology


 
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How to Cite this Article
Pubmed Style

Laudin G, Levay P, Ndhlebe G. A case of a periosteal reaction in a patient with paroxysmal nocturnal haemoglobinuria newly diagnosed with acute myeloid leukaemia: A South African perspective. Int J Med Rev Case Rep. 2020; 4(5): 81-84. doi:10.5455/IJMRCR.paroxysmal-nocturnal-haemoglobinuria-hematuria


Web Style

Laudin G, Levay P, Ndhlebe G. A case of a periosteal reaction in a patient with paroxysmal nocturnal haemoglobinuria newly diagnosed with acute myeloid leukaemia: A South African perspective. http://www.mdpub.net/?mno=87730 [Access: July 02, 2020]. doi:10.5455/IJMRCR.paroxysmal-nocturnal-haemoglobinuria-hematuria


AMA (American Medical Association) Style

Laudin G, Levay P, Ndhlebe G. A case of a periosteal reaction in a patient with paroxysmal nocturnal haemoglobinuria newly diagnosed with acute myeloid leukaemia: A South African perspective. Int J Med Rev Case Rep. 2020; 4(5): 81-84. doi:10.5455/IJMRCR.paroxysmal-nocturnal-haemoglobinuria-hematuria



Vancouver/ICMJE Style

Laudin G, Levay P, Ndhlebe G. A case of a periosteal reaction in a patient with paroxysmal nocturnal haemoglobinuria newly diagnosed with acute myeloid leukaemia: A South African perspective. Int J Med Rev Case Rep. (2020), [cited July 02, 2020]; 4(5): 81-84. doi:10.5455/IJMRCR.paroxysmal-nocturnal-haemoglobinuria-hematuria



Harvard Style

Laudin, G., Levay, . P. & Ndhlebe, . G. (2020) A case of a periosteal reaction in a patient with paroxysmal nocturnal haemoglobinuria newly diagnosed with acute myeloid leukaemia: A South African perspective. Int J Med Rev Case Rep, 4 (5), 81-84. doi:10.5455/IJMRCR.paroxysmal-nocturnal-haemoglobinuria-hematuria



Turabian Style

Laudin, Garrick, Peter Levay, and Gugulethu Ndhlebe. 2020. A case of a periosteal reaction in a patient with paroxysmal nocturnal haemoglobinuria newly diagnosed with acute myeloid leukaemia: A South African perspective. International Journal of Medical Reviews and Case Reports, 4 (5), 81-84. doi:10.5455/IJMRCR.paroxysmal-nocturnal-haemoglobinuria-hematuria



Chicago Style

Laudin, Garrick, Peter Levay, and Gugulethu Ndhlebe. "A case of a periosteal reaction in a patient with paroxysmal nocturnal haemoglobinuria newly diagnosed with acute myeloid leukaemia: A South African perspective." International Journal of Medical Reviews and Case Reports 4 (2020), 81-84. doi:10.5455/IJMRCR.paroxysmal-nocturnal-haemoglobinuria-hematuria



MLA (The Modern Language Association) Style

Laudin, Garrick, Peter Levay, and Gugulethu Ndhlebe. "A case of a periosteal reaction in a patient with paroxysmal nocturnal haemoglobinuria newly diagnosed with acute myeloid leukaemia: A South African perspective." International Journal of Medical Reviews and Case Reports 4.5 (2020), 81-84. Print. doi:10.5455/IJMRCR.paroxysmal-nocturnal-haemoglobinuria-hematuria



APA (American Psychological Association) Style

Laudin, G., Levay, . P. & Ndhlebe, . G. (2020) A case of a periosteal reaction in a patient with paroxysmal nocturnal haemoglobinuria newly diagnosed with acute myeloid leukaemia: A South African perspective. International Journal of Medical Reviews and Case Reports, 4 (5), 81-84. doi:10.5455/IJMRCR.paroxysmal-nocturnal-haemoglobinuria-hematuria