E-ISSN 2534-9821
 

Case Report
Online Published: 15 Jul 2020
 


Large cell neuroendocrine carcinoma of cervix: A rare and distinct clinicopathological entity

Nazish Khalid, Faizan Ullah, Jehanzeb Iftikhar, Tabinda Sadaf, Osama Shakeel.


Cited By: 1

Abstract
Large cell neuroendocrine carcinoma (LCNEC) is a rare malignancy and accounts for only 1% of cervical malignancies. The mean age is 34 years, ranges from 21 to 62 years. It usually presents with abnormal Pap smear or vaginal bleeding. LCNEC shows an aggressive behavior, similar to lung counterpart, with early metastases to regional lymph nodes and liver, lung, bone and brain. Median survival is <2 years. Due to the rarity of this malignancy, the management of LCNEC is difficult and associated with uncertainty. An interdisciplinary approach is necessary because most studies investigating the treatment of neuroendocrine tumors have been performed in patients with tumors in organs other than cervix, mostly the lung and pancreas. The biology of LCNEC is different from the squamous cell carcinoma or adenocarcinoma of the cervix regarding a number of characteristics. LCNEC is more likely to invade the lymph nodes at the time of diagnosis and local and distant relapses occur more often in LCNEC. Overall survival is significantly poor compared to squamous cell carcinoma and adenocarcinoma of the cervix

Key words: Ovarian Cancer, Neuroendocrine Carcinoma, Rare cancer of ovary


 
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This Article Cited By the following articles

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European Journal of Obstetrics & Gynecology and Reproductive Biology 2022; 270(): 212.

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How to Cite this Article
Pubmed Style

Khalid N, Ullah F, Iftikhar J, Sadaf T, Shakeel O. Large cell neuroendocrine carcinoma of cervix: A rare and distinct clinicopathological entity. Int J Med Rev Case Rep. 2020; 4(10): 76-78. doi:10.5455/IJMRCR.Large-cell-neuroendocrine-carcinoma-of-cervix


Web Style

Khalid N, Ullah F, Iftikhar J, Sadaf T, Shakeel O. Large cell neuroendocrine carcinoma of cervix: A rare and distinct clinicopathological entity. https://www.mdpub.net/?mno=111149 [Access: October 13, 2024]. doi:10.5455/IJMRCR.Large-cell-neuroendocrine-carcinoma-of-cervix


AMA (American Medical Association) Style

Khalid N, Ullah F, Iftikhar J, Sadaf T, Shakeel O. Large cell neuroendocrine carcinoma of cervix: A rare and distinct clinicopathological entity. Int J Med Rev Case Rep. 2020; 4(10): 76-78. doi:10.5455/IJMRCR.Large-cell-neuroendocrine-carcinoma-of-cervix



Vancouver/ICMJE Style

Khalid N, Ullah F, Iftikhar J, Sadaf T, Shakeel O. Large cell neuroendocrine carcinoma of cervix: A rare and distinct clinicopathological entity. Int J Med Rev Case Rep. (2020), [cited October 13, 2024]; 4(10): 76-78. doi:10.5455/IJMRCR.Large-cell-neuroendocrine-carcinoma-of-cervix



Harvard Style

Khalid, N., Ullah, . F., Iftikhar, . J., Sadaf, . T. & Shakeel, . O. (2020) Large cell neuroendocrine carcinoma of cervix: A rare and distinct clinicopathological entity. Int J Med Rev Case Rep, 4 (10), 76-78. doi:10.5455/IJMRCR.Large-cell-neuroendocrine-carcinoma-of-cervix



Turabian Style

Khalid, Nazish, Faizan Ullah, Jehanzeb Iftikhar, Tabinda Sadaf, and Osama Shakeel. 2020. Large cell neuroendocrine carcinoma of cervix: A rare and distinct clinicopathological entity. International Journal of Medical Reviews and Case Reports, 4 (10), 76-78. doi:10.5455/IJMRCR.Large-cell-neuroendocrine-carcinoma-of-cervix



Chicago Style

Khalid, Nazish, Faizan Ullah, Jehanzeb Iftikhar, Tabinda Sadaf, and Osama Shakeel. "Large cell neuroendocrine carcinoma of cervix: A rare and distinct clinicopathological entity." International Journal of Medical Reviews and Case Reports 4 (2020), 76-78. doi:10.5455/IJMRCR.Large-cell-neuroendocrine-carcinoma-of-cervix



MLA (The Modern Language Association) Style

Khalid, Nazish, Faizan Ullah, Jehanzeb Iftikhar, Tabinda Sadaf, and Osama Shakeel. "Large cell neuroendocrine carcinoma of cervix: A rare and distinct clinicopathological entity." International Journal of Medical Reviews and Case Reports 4.10 (2020), 76-78. Print. doi:10.5455/IJMRCR.Large-cell-neuroendocrine-carcinoma-of-cervix



APA (American Psychological Association) Style

Khalid, N., Ullah, . F., Iftikhar, . J., Sadaf, . T. & Shakeel, . O. (2020) Large cell neuroendocrine carcinoma of cervix: A rare and distinct clinicopathological entity. International Journal of Medical Reviews and Case Reports, 4 (10), 76-78. doi:10.5455/IJMRCR.Large-cell-neuroendocrine-carcinoma-of-cervix