E-ISSN 2534-9821
 

Case Report 


NEONATAL THROMBOSIS ASSOCIATED WITH FETAL VASCULAR MALPERFUSION: A CASE REPORT

Marina Mota, Raquel Henriques , Carolina Gonçalves, Raquel Gouveia, Andreia Fonseca, José Eduardo Silva, Maria João Palaré.

Abstract
Background: Fetal vascular malperfusion refers to placental lesions indicating reduced or absent perfusion of the villous parenchyma by the fetus. Fetal vascular malperfusion remains an underrecognized condition that is associated with adverse perinatal outcomes. It may also predispose infants to thromboembolic events. There are few cases described of inferior vena cava and renal vein thrombosis in an asymptomatic newborn.
Case presentation: We report the case of an asymptomatic female neonate delivered at 32 weeks of gestation to a mother with type 1 diabetes and preeclampsia. Prenatal diagnosis of renal vein and inferior vena cava thrombosis was made at 30 weeks. Thrombophilia work-up was negative. Diagnosis was guided by the placental pathological examination that showed thrombosis of several fetal vessels of the chorionic plate, high-grade poor perfusion lesions and distal villous hypoplasia, suggestive of Fetal vascular malperfusion. Treatment with low-molecular-weight heparin was effective in the complete resolution of the thrombus and preservation of renal function.
Conclusion: This case emphasizes the importance of placental pathological examination in the presence of fetal abnormalities. Fetal vascular malperfusion may cause unrecognized neonatal thrombosis, which may result in growth impairment or organic dysfunction. Pregnant women with known risk factors for Fetal vascular malperfusion should be monitored more closely, both antenatally and postnatally, to detect possible placental and fetal target organ involvement at an early stage.

Key words: fetal vascular malperfusion; thrombosis; neonate; preterm; treatment; outcome


 
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How to Cite this Article
Pubmed Style

Mota M, RH, Goncalves C, Gouveia R, Fonseca A, Silva JE, Palaré MJ, . NEONATAL THROMBOSIS ASSOCIATED WITH FETAL VASCULAR MALPERFUSION: A CASE REPORT. Int J Med Rev Case Rep. 2023; 7(6): 1-3. doi:10.5455/IJMRCR.172-1666204438


Web Style

Mota M, RH, Goncalves C, Gouveia R, Fonseca A, Silva JE, Palaré MJ, . NEONATAL THROMBOSIS ASSOCIATED WITH FETAL VASCULAR MALPERFUSION: A CASE REPORT. https://www.mdpub.net/?mno=122731 [Access: December 15, 2023]. doi:10.5455/IJMRCR.172-1666204438


AMA (American Medical Association) Style

Mota M, RH, Goncalves C, Gouveia R, Fonseca A, Silva JE, Palaré MJ, . NEONATAL THROMBOSIS ASSOCIATED WITH FETAL VASCULAR MALPERFUSION: A CASE REPORT. Int J Med Rev Case Rep. 2023; 7(6): 1-3. doi:10.5455/IJMRCR.172-1666204438



Vancouver/ICMJE Style

Mota M, RH, Goncalves C, Gouveia R, Fonseca A, Silva JE, Palaré MJ, . NEONATAL THROMBOSIS ASSOCIATED WITH FETAL VASCULAR MALPERFUSION: A CASE REPORT. Int J Med Rev Case Rep. (2023), [cited December 15, 2023]; 7(6): 1-3. doi:10.5455/IJMRCR.172-1666204438



Harvard Style

Mota, M., , R. H., Goncalves, C., Gouveia, R., Fonseca, A., Silva, J. E., Palaré, M. J. & (2023) NEONATAL THROMBOSIS ASSOCIATED WITH FETAL VASCULAR MALPERFUSION: A CASE REPORT. Int J Med Rev Case Rep, 7 (6), 1-3. doi:10.5455/IJMRCR.172-1666204438



Turabian Style

Mota, Marina, Raquel Henriques, Carolina Goncalves, Raquel Gouveia, Andreia Fonseca, José Eduardo Silva, Maria João Palaré, and . 2023. NEONATAL THROMBOSIS ASSOCIATED WITH FETAL VASCULAR MALPERFUSION: A CASE REPORT. International Journal of Medical Reviews and Case Reports, 7 (6), 1-3. doi:10.5455/IJMRCR.172-1666204438



Chicago Style

Mota, Marina, Raquel Henriques, Carolina Goncalves, Raquel Gouveia, Andreia Fonseca, José Eduardo Silva, Maria João Palaré, and . "NEONATAL THROMBOSIS ASSOCIATED WITH FETAL VASCULAR MALPERFUSION: A CASE REPORT." International Journal of Medical Reviews and Case Reports 7 (2023), 1-3. doi:10.5455/IJMRCR.172-1666204438



MLA (The Modern Language Association) Style

Mota, Marina, Raquel Henriques, Carolina Goncalves, Raquel Gouveia, Andreia Fonseca, José Eduardo Silva, Maria João Palaré, and . "NEONATAL THROMBOSIS ASSOCIATED WITH FETAL VASCULAR MALPERFUSION: A CASE REPORT." International Journal of Medical Reviews and Case Reports 7.6 (2023), 1-3. Print. doi:10.5455/IJMRCR.172-1666204438



APA (American Psychological Association) Style

Mota, M., , R. H., Goncalves, C., Gouveia, R., Fonseca, A., Silva, J. E., Palaré, M. J. & (2023) NEONATAL THROMBOSIS ASSOCIATED WITH FETAL VASCULAR MALPERFUSION: A CASE REPORT. International Journal of Medical Reviews and Case Reports, 7 (6), 1-3. doi:10.5455/IJMRCR.172-1666204438