Abstract
Background:
Both inductions of anaesthesia and airway management are the critical part of conducting general anaesthesia. The common complications following injection of induction agent especially in hemodynamically unstable patients range from hypotension to arrhythmias subsequently leading to cardiovascular collapse. Conversely, airway manipulation during laryngoscopy and tracheal Intubation may cause arrhythmias, hypertension, myocardial injury, airway spasm, hypoxia, hypercarbia, and raised intracranial and intraocular pressure.
Aims and Objective:
To compare the hemodynamic response to laryngoscopy and tracheal Intubation after induction of anaesthesia by Propofol and Etomidate. It is also to compare the incidence of myoclonus, oxygen saturation and postoperative nausea and vomiting.
Materials and methods:
One hundred thirty American Society of Anaesthesiology grade I and II patients of age group 18-50 years scheduled for the planned surgical procedure under general anaesthesia were randomly divided into two groups of 65 each receiving Propofol 2 mg/kg and Etomidate 0.3 mg/kg as an induction agent. Vital parameters were measured at induction and after intubation for comparison. Myoclonus and oxygenation saturation was noted after induction.
Results:
Both groups are comparable in terms of demographic variables. The statistical evaluation showed that the decrease in blood pressure was statistically significant (p<0.05) in group P on induction whereas there is a significant (p<0.05) increase in blood pressure and heart rate in group E after intubation. There was no difference with regard to oxygen saturation and postoperative nausea and vomiting.
Conclusion:
Etomidate is a more hemodynamically stable induction agent compared to Propofol but is less effective in preventing stress response to laryngoscopy and tracheal intubation with a higher incidence of myoclonus on induction if proper premedication is not used.

Key words: Hemodynamic Response, Induction Agent, Laryngoscopy, Myoclonus, Tracheal Intubation