Serum Uric Acid Levels In Patients With Diabetes Mellitus And Its Correlation With Glomerular Filtration Rate

PN Ramani; Anup Narayanan; Jaison Varghese; Renjith James

doi:10.5455/IJMRCR.172-1669739865

2023, Vol: 7, Issue: 11

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Original Research
Online Published: 21 Sep 2023

Int J Med Rev Case Rep. 2023; 7(8): 6-9

doi: 10.5455/IJMRCR.172-1669739865

Serum Uric Acid Levels In Patients With Diabetes Mellitus And Its Correlation With Glomerular Filtration Rate

PN Ramani, Anup Narayanan, Jaison Varghese, Renjith James.

Abstract
Context: Serum uric acid is a potential risk factor for development of type 2 Diabetes Mellitus. Hyperuricemia is frequently found in persons with metabolic syndrome.
Aim: To compare the serum uric acid in the normal population and in those with diabetes mellitus.
Settings and Design: A comparative study was conducted in a tertiary-care teaching hospital in South India, with 100 patients with type 2 diabetes mellitus and 100 healthy controls.
Methods and Material: Serum uric acid levels were compared in patients with diabetes and the controls. The serum uric acid levels of the cases and controls were correlated with GFR. Association with factors such as age, gender, BMI, duration of diabetes, proteinuria and hypertension were looked for.
Statistical analysis used: Appropriate test of significance such as Student t test, one-way ANOVA test and Pearson’s correlation were used. A p-value of less than 0.05 was considered significant.
Results: The mean GFR in cases were 82.6 and in controls were 116.76. The mean serum uric acid levels were significantly higher among cases as compared to controls (4.8 v/s 3.7 mg/dl. A weak negative correlation was obtained between serum uric acid levels and GFR, both in diabetics as well as healthy controls.
Conclusions: Serum uric acid levels were higher in patients with diabetes mellitus than in the normal population. Those with elevated serum uric acid levels were found to have reduced GFR.

Key words: Diabetes mellitus, Glomerular Filtration Rate, Serum uric acid

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Pubmed Style

Ramani P, Narayanan A, Varghese J, James R. Serum Uric Acid Levels In Patients With Diabetes Mellitus And Its Correlation With Glomerular Filtration Rate. Int J Med Rev Case Rep. 2023; 7(8): 6-9. doi:10.5455/IJMRCR.172-1669739865

Web Style

Ramani P, Narayanan A, Varghese J, James R. Serum Uric Acid Levels In Patients With Diabetes Mellitus And Its Correlation With Glomerular Filtration Rate. https://www.mdpub.net/?mno=12686 [Access: October 13, 2024]. doi:10.5455/IJMRCR.172-1669739865

AMA (American Medical Association) Style

Ramani P, Narayanan A, Varghese J, James R. Serum Uric Acid Levels In Patients With Diabetes Mellitus And Its Correlation With Glomerular Filtration Rate. Int J Med Rev Case Rep. 2023; 7(8): 6-9. doi:10.5455/IJMRCR.172-1669739865

Vancouver/ICMJE Style

Ramani P, Narayanan A, Varghese J, James R. Serum Uric Acid Levels In Patients With Diabetes Mellitus And Its Correlation With Glomerular Filtration Rate. Int J Med Rev Case Rep. (2023), [cited October 13, 2024]; 7(8): 6-9. doi:10.5455/IJMRCR.172-1669739865

Harvard Style

Ramani, P., Narayanan, . A., Varghese, . J. & James, . R. (2023) Serum Uric Acid Levels In Patients With Diabetes Mellitus And Its Correlation With Glomerular Filtration Rate. Int J Med Rev Case Rep, 7 (8), 6-9. doi:10.5455/IJMRCR.172-1669739865

Turabian Style

Ramani, PN, Anup Narayanan, Jaison Varghese, and Renjith James. 2023. Serum Uric Acid Levels In Patients With Diabetes Mellitus And Its Correlation With Glomerular Filtration Rate. International Journal of Medical Reviews and Case Reports, 7 (8), 6-9. doi:10.5455/IJMRCR.172-1669739865

Chicago Style

Ramani, PN, Anup Narayanan, Jaison Varghese, and Renjith James. "Serum Uric Acid Levels In Patients With Diabetes Mellitus And Its Correlation With Glomerular Filtration Rate." International Journal of Medical Reviews and Case Reports 7 (2023), 6-9. doi:10.5455/IJMRCR.172-1669739865

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Ramani, P., Narayanan, . A., Varghese, . J. & James, . R. (2023) Serum Uric Acid Levels In Patients With Diabetes Mellitus And Its Correlation With Glomerular Filtration Rate. International Journal of Medical Reviews and Case Reports, 7 (8), 6-9. doi:10.5455/IJMRCR.172-1669739865

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