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Original Research
Online Published: 09 May 2023
 


Evaluating the efficacy of combination therapy of Pregabalin plus Nortriptyline in the management of PHN patients: A randomized controlled study

Swati Das, Ashok Kumar Saxena, Geetanjali T Chilkoti, Anshul Singh, Sargam Goel.


Abstract
Background: Post Herpetic Neuralgia (PHN) is chronic neuropathic pain. It is a complication of herpes zoster and negatively impacts the patient’s quality of life and physical, occupational, social and psychosocial abilities due to unceasing pain. As pain management remains the cornerstone in treating such patients, this study was undertaken to determine the efficacy of fixed-dose combination therapy of Pregabalin plus Nortriptyline in PHN.
Methods: The study, which was a follow-up, randomised, single-blind, controlled study, included a total of 40 patients who had chronic pain for at least 12 weeks with a Numeric rating scale (NRS) score of 5/10 or above. Group A (n=20) received pregabalin 75 mg plus nortriptyline 10 mg, and group B (n=20) received pregabalin 75 mg for a total of 12 weeks. Pain intensity and severity (using NRS and Global Perceived Effect), pain interference with sleep (using Numeric Rating Scale-Sleep (NRS-Sleep) and Pain Detect Questionnaire (PDQ)), pain quality (using Neuropathic Pain Symptom Inventory (NPSI)), and quality of life (QoL) (using Short Form-12 (SF-12) questionnaire) at the end of the first, second, fourth, eighth and twelfth week were measured.
Results: Significant (p <0.05) decline in Numeric rating scale (NRS) scores, NRS sleep and NPSI scores in group A along with significant (p <0.05) improvement in PDQ, GPE and QoL scores, when compared to group B.
Conclusion: The combination of pregabalin plus nortriptyline therapy has better patient outcomes in PHN as compared to pregabalin monotherapy.

Key words: Post Herpetic Neuralgia; Pregabalin; Nortriptyline; Numeric Rating Scale


 
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How to Cite this Article
Pubmed Style

Das S, Saxena AK, Chilkoti GT, Singh A, Goel S. Evaluating the efficacy of combination therapy of Pregabalin plus Nortriptyline in the management of PHN patients: A randomized controlled study. Int J Med Rev Case Rep. 2023; 7(5): 42-46. doi:10.5455/IJMRCR.172-1669175453

Web Style

Das S, Saxena AK, Chilkoti GT, Singh A, Goel S. Evaluating the efficacy of combination therapy of Pregabalin plus Nortriptyline in the management of PHN patients: A randomized controlled study. https://www.mdpub.net/?mno=131875 [Access: April 02, 2025]. doi:10.5455/IJMRCR.172-1669175453

AMA (American Medical Association) Style

Das S, Saxena AK, Chilkoti GT, Singh A, Goel S. Evaluating the efficacy of combination therapy of Pregabalin plus Nortriptyline in the management of PHN patients: A randomized controlled study. Int J Med Rev Case Rep. 2023; 7(5): 42-46. doi:10.5455/IJMRCR.172-1669175453


Vancouver/ICMJE Style

Das S, Saxena AK, Chilkoti GT, Singh A, Goel S. Evaluating the efficacy of combination therapy of Pregabalin plus Nortriptyline in the management of PHN patients: A randomized controlled study. Int J Med Rev Case Rep. (2023), [cited April 02, 2025]; 7(5): 42-46. doi:10.5455/IJMRCR.172-1669175453


Harvard Style

Das, S., Saxena, . A. K., Chilkoti, . G. T., Singh, . A. & Goel, . S. (2023) Evaluating the efficacy of combination therapy of Pregabalin plus Nortriptyline in the management of PHN patients: A randomized controlled study. Int J Med Rev Case Rep, 7 (5), 42-46. doi:10.5455/IJMRCR.172-1669175453


Turabian Style

Das, Swati, Ashok Kumar Saxena, Geetanjali T Chilkoti, Anshul Singh, and Sargam Goel. 2023. Evaluating the efficacy of combination therapy of Pregabalin plus Nortriptyline in the management of PHN patients: A randomized controlled study. International Journal of Medical Reviews and Case Reports, 7 (5), 42-46. doi:10.5455/IJMRCR.172-1669175453


Chicago Style

Das, Swati, Ashok Kumar Saxena, Geetanjali T Chilkoti, Anshul Singh, and Sargam Goel. "Evaluating the efficacy of combination therapy of Pregabalin plus Nortriptyline in the management of PHN patients: A randomized controlled study." International Journal of Medical Reviews and Case Reports 7 (2023), 42-46. doi:10.5455/IJMRCR.172-1669175453


MLA (The Modern Language Association) Style

Das, Swati, Ashok Kumar Saxena, Geetanjali T Chilkoti, Anshul Singh, and Sargam Goel. "Evaluating the efficacy of combination therapy of Pregabalin plus Nortriptyline in the management of PHN patients: A randomized controlled study." International Journal of Medical Reviews and Case Reports 7.5 (2023), 42-46. Print. doi:10.5455/IJMRCR.172-1669175453


APA (American Psychological Association) Style

Das, S., Saxena, . A. K., Chilkoti, . G. T., Singh, . A. & Goel, . S. (2023) Evaluating the efficacy of combination therapy of Pregabalin plus Nortriptyline in the management of PHN patients: A randomized controlled study. International Journal of Medical Reviews and Case Reports, 7 (5), 42-46. doi:10.5455/IJMRCR.172-1669175453


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