E-ISSN 2534-9821
 

Original Article 


Diagnosis Embattled - Correlation of Serum Ferritin and Lipid Profile with Severity of Dengue in Paediatric Population

Mohit V Rojekar, Vandana Kumavat, Jayesh Panot, Arati Adhe Rojekar, Poonam Lalla.

Abstract
Introduction: Dengue is a highly prevalent mosquito-borne disease which requires serum ferritin and lipid profile testing to understand the severity of the infection. Iron and lipids are essential elements for the formation of viral organelles and the proliferation of DNGV. Hyperferritinaemia correlates with the severity of Dengue virus (DNGV) infection. Serum ferritin level is disproportionately high and indicates the increased risk of developing the complications. Hypolipidaemia is an independent predictor of the severity of dengue infection in critical patients. Due to the unavailability of dengue treatment, there is an upsurge in the demand for a prognostic biomarker for the DNGV infection. In dengue fever, serum ferritin is disproportionately raised compared to any bacterial or viral infection and this elevated level substantiates an increased risk of rising complications.
Objective: This study is aimed to investigate the correlation of serum ferritin, platelets and lipid profile with disease severity and if these could serve as a predictive marker for progression to severe disease.
Materials and Methods: This cross-sectional, observational study was conducted on 100 subjects (50 cases and 50 controls) in a tertiary care referral hospital in western India. Complete blood count at the time of admission and at 48 hours along with Ferritin, renal and liver function tests, and lipid profile were performed on XL-640 Biochemistry FAA manufactured by Transasia Biomedicals, ERBA Mannheim. Tests to identify the normality of data distribution and tests of correlation were applied.
Result: Platelet (p=0.02), total cholesterol (p=0.04), LDL (p=0.04) were found to be decreased while ferritin (p<0.05) and TG (p<0.05) were found to be significantly increased in cases than in controls. In cases and controls, the difference in the levels of HDL and VLDL were not found to be statistically significant.
Conclusion: The present study had shown that elevated serum ferritin levels done on admission or on the diagnosis of the illness can predict the severity of dengue. Further research is needed to study the exact role of lipid profile in dengue.

Key words: Aedes aegypti, Severity, Lipid profile, Platelets, Paediatric dengue, mosquito borne


 
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How to Cite this Article
Pubmed Style

Rojekar MV, Kumavat V, Panot J, Rojekar AA, Lalla P. Diagnosis Embattled - Correlation of Serum Ferritin and Lipid Profile with Severity of Dengue in Paediatric Population. Int J Med Rev Case Rep. 2021; 5(2): 12-16. doi:10.5455/IJMRCR.Serum-Ferritin-lipid-profile-dengue-pediatric


Web Style

Rojekar MV, Kumavat V, Panot J, Rojekar AA, Lalla P. Diagnosis Embattled - Correlation of Serum Ferritin and Lipid Profile with Severity of Dengue in Paediatric Population. https://www.mdpub.net/?mno=132810 [Access: September 12, 2022]. doi:10.5455/IJMRCR.Serum-Ferritin-lipid-profile-dengue-pediatric


AMA (American Medical Association) Style

Rojekar MV, Kumavat V, Panot J, Rojekar AA, Lalla P. Diagnosis Embattled - Correlation of Serum Ferritin and Lipid Profile with Severity of Dengue in Paediatric Population. Int J Med Rev Case Rep. 2021; 5(2): 12-16. doi:10.5455/IJMRCR.Serum-Ferritin-lipid-profile-dengue-pediatric



Vancouver/ICMJE Style

Rojekar MV, Kumavat V, Panot J, Rojekar AA, Lalla P. Diagnosis Embattled - Correlation of Serum Ferritin and Lipid Profile with Severity of Dengue in Paediatric Population. Int J Med Rev Case Rep. (2021), [cited September 12, 2022]; 5(2): 12-16. doi:10.5455/IJMRCR.Serum-Ferritin-lipid-profile-dengue-pediatric



Harvard Style

Rojekar, M. V., Kumavat, . V., Panot, . J., Rojekar, . A. A. & Lalla, . P. (2021) Diagnosis Embattled - Correlation of Serum Ferritin and Lipid Profile with Severity of Dengue in Paediatric Population. Int J Med Rev Case Rep, 5 (2), 12-16. doi:10.5455/IJMRCR.Serum-Ferritin-lipid-profile-dengue-pediatric



Turabian Style

Rojekar, Mohit V, Vandana Kumavat, Jayesh Panot, Arati Adhe Rojekar, and Poonam Lalla. 2021. Diagnosis Embattled - Correlation of Serum Ferritin and Lipid Profile with Severity of Dengue in Paediatric Population. International Journal of Medical Reviews and Case Reports, 5 (2), 12-16. doi:10.5455/IJMRCR.Serum-Ferritin-lipid-profile-dengue-pediatric



Chicago Style

Rojekar, Mohit V, Vandana Kumavat, Jayesh Panot, Arati Adhe Rojekar, and Poonam Lalla. "Diagnosis Embattled - Correlation of Serum Ferritin and Lipid Profile with Severity of Dengue in Paediatric Population." International Journal of Medical Reviews and Case Reports 5 (2021), 12-16. doi:10.5455/IJMRCR.Serum-Ferritin-lipid-profile-dengue-pediatric



MLA (The Modern Language Association) Style

Rojekar, Mohit V, Vandana Kumavat, Jayesh Panot, Arati Adhe Rojekar, and Poonam Lalla. "Diagnosis Embattled - Correlation of Serum Ferritin and Lipid Profile with Severity of Dengue in Paediatric Population." International Journal of Medical Reviews and Case Reports 5.2 (2021), 12-16. Print. doi:10.5455/IJMRCR.Serum-Ferritin-lipid-profile-dengue-pediatric



APA (American Psychological Association) Style

Rojekar, M. V., Kumavat, . V., Panot, . J., Rojekar, . A. A. & Lalla, . P. (2021) Diagnosis Embattled - Correlation of Serum Ferritin and Lipid Profile with Severity of Dengue in Paediatric Population. International Journal of Medical Reviews and Case Reports, 5 (2), 12-16. doi:10.5455/IJMRCR.Serum-Ferritin-lipid-profile-dengue-pediatric