Correlation of CT staging and biochemical parameters in assessing disease severity and mortality of COVID-19 patients

Kalpana Radhakrishnan; Thangalakshmi Adaikkalam; Rajendran Velayutham; Karthick Rajendran

doi:10.5455/IJMRCR.172-1678464451

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Original Research
Online Published: 14 May 2023

Int J Med Rev Case Rep. 2023; 7(6): 14-19

doi: 10.5455/IJMRCR.172-1678464451

Correlation of CT staging and biochemical parameters in assessing disease severity and mortality of COVID-19 patients

Kalpana Radhakrishnan, Thangalakshmi Adaikkalam, Rajendran Velayutham, Karthick Rajendran.

Abstract
Background:
CT chest has become the front-line investigation even for a Real-time polymerase chain reaction (RT-PCR) negative patient due to low viral load. Many grading systems were formulated to assess the severity of lung involvement and combined with inflammatory markers like ferritin (Fr) and C reactive protein (CRP) to provide a guide for diagnosing and managing COVID patients.
Methods:
After being tested with RT-PCR, Severe acute respiratory syndrome coronavirus -2(SARS-CoV-2) patients who were referred for CT were included in our study. A non-contrast CT scan of the chest was obtained with 16 slice -Toshiba with 1mm collimation. Findings documented included the presence and extent of ground glass opacities; consolidation whether round, linear, patchy, lobar, or diffuse; septal thickening; and other features of pre-existing diseases like cavity, bronchiectasis, pleural effusion, and cardiomegaly. CT staging was done based on the progress of the disease and compared with biochemical parameters.
Results: 571 patients; between the ages of 19 and 88 suspected to have Coronavirus pneumonia were included in the study. CT stages were compared with the median value of LDH, Fr, TGL, AND CRP All biochemical parameters LDH 692 (438.5 -771 ) (p-value 0.0001), Fr 1.27 (0.64 -1.89) (p-value 0.0001), and CRP (113.4 (95.5 2-207.7 ) (p-value 0.0001), were elevated in higher CT stages. Both elevated biochemical parameters and higher CT stages were associated with the severity and mortality of the disease. No significant p-value was noted with TGL.
Conclusions:
Covid 19 pneumonia starts as a respiratory infection but spreads to become a systemic disease. The inflammation is associated with an increase in biochemical parameters which correlate with the staging of the lung by CT and in dead patients.

Key words: Computed tomography, Real-time polymerase chain reaction, biochemical parameters, SARS-CoV-2

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How to Cite this Article

Pubmed Style

Radhakrishnan K, Adaikkalam T, Velayutham R, Rajendran K. Correlation of CT staging and biochemical parameters in assessing disease severity and mortality of COVID-19 patients. Int J Med Rev Case Rep. 2023; 7(6): 14-19. doi:10.5455/IJMRCR.172-1678464451

Web Style

Radhakrishnan K, Adaikkalam T, Velayutham R, Rajendran K. Correlation of CT staging and biochemical parameters in assessing disease severity and mortality of COVID-19 patients. https://www.mdpub.net/?mno=145993 [Access: October 13, 2024]. doi:10.5455/IJMRCR.172-1678464451

AMA (American Medical Association) Style

Radhakrishnan K, Adaikkalam T, Velayutham R, Rajendran K. Correlation of CT staging and biochemical parameters in assessing disease severity and mortality of COVID-19 patients. Int J Med Rev Case Rep. 2023; 7(6): 14-19. doi:10.5455/IJMRCR.172-1678464451

Vancouver/ICMJE Style

Radhakrishnan K, Adaikkalam T, Velayutham R, Rajendran K. Correlation of CT staging and biochemical parameters in assessing disease severity and mortality of COVID-19 patients. Int J Med Rev Case Rep. (2023), [cited October 13, 2024]; 7(6): 14-19. doi:10.5455/IJMRCR.172-1678464451

Harvard Style

Radhakrishnan, K., Adaikkalam, . T., Velayutham, . R. & Rajendran, . K. (2023) Correlation of CT staging and biochemical parameters in assessing disease severity and mortality of COVID-19 patients. Int J Med Rev Case Rep, 7 (6), 14-19. doi:10.5455/IJMRCR.172-1678464451

Turabian Style

Radhakrishnan, Kalpana, Thangalakshmi Adaikkalam, Rajendran Velayutham, and Karthick Rajendran. 2023. Correlation of CT staging and biochemical parameters in assessing disease severity and mortality of COVID-19 patients. International Journal of Medical Reviews and Case Reports, 7 (6), 14-19. doi:10.5455/IJMRCR.172-1678464451

Chicago Style

Radhakrishnan, Kalpana, Thangalakshmi Adaikkalam, Rajendran Velayutham, and Karthick Rajendran. "Correlation of CT staging and biochemical parameters in assessing disease severity and mortality of COVID-19 patients." International Journal of Medical Reviews and Case Reports 7 (2023), 14-19. doi:10.5455/IJMRCR.172-1678464451

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Radhakrishnan, K., Adaikkalam, . T., Velayutham, . R. & Rajendran, . K. (2023) Correlation of CT staging and biochemical parameters in assessing disease severity and mortality of COVID-19 patients. International Journal of Medical Reviews and Case Reports, 7 (6), 14-19. doi:10.5455/IJMRCR.172-1678464451

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