THE ROLE  OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN

Pascanus LP Togatorop; Faldi Yaputra; Jimmy FA Barus; I Putu Eka Widyadharma

doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

Review Article
Online Published: 30 Aug 2018

Int J Med Rev Case Rep. 2018; 2(3): 58-61

doi: 10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN

Pascanus Lp Togatorop, Faldi Yaputra, Jimmy Fa Barus, I Putu Eka Widyadharma.

Abstract
Neuropathic pain (NP) is a pain caused by lesions in the nervous system. Several causes of NP are traumatic, metabolic disorders, ischemia, toxins, infections, immune-related, and hereditary. The pathophysiology of NP is very complicated and unknown entirely. Therefore the treatment of NP is still unsatisfactory. Recent studies believed the critical role of primary inflammatory mediators in the pathophysiology of NP especially leukotrienes (LTs). The 5-lipoxygenase enzyme (5-LOX) is an enzyme that plays a role in the metabolism of arachidonic acid into LTs. Leukotrienes (LTs) are the essential inflammatory mediators in the pathophysiology of NP. Leukotriene B4 (LTB4) can cause chemotaxis on neutrophils, lowering nociceptors threshold and may contribute to NP. Several studies believed the administration of 5-LOX inhibitors or LTs receptor antagonists could be useful in the management of NP. The purpose of this review is to summarize the involvement of 5-LOX enzyme as an essential role in the pathophysiology and management of NP.

Key words: 5-lipoxygenase, leukotrienes, pathophysiology of neuropathic pain, inflammatory mediators, management of neuropathic pain

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Pubmed Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE. THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep. 2018; 2(3): 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

Web Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE. THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. https://www.mdpub.net/?mno=2428 [Access: April 02, 2025]. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

AMA (American Medical Association) Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE. THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep. 2018; 2(3): 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

Vancouver/ICMJE Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE. THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep. (2018), [cited April 02, 2025]; 2(3): 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

Harvard Style

Togatorop, P. L., Yaputra, . F. ., Barus, . J. F. & Widyadharma, . I. P. . E. (2018) THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep, 2 (3), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

Turabian Style

Togatorop, Pascanus Lp, Faldi Yaputra, Jimmy Fa Barus, and I Putu Eka Widyadharma. 2018. THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. International Journal of Medical Reviews and Case Reports, 2 (3), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

Chicago Style

Togatorop, Pascanus Lp, Faldi Yaputra, Jimmy Fa Barus, and I Putu Eka Widyadharma. "THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN." International Journal of Medical Reviews and Case Reports 2 (2018), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

MLA (The Modern Language Association) Style

Togatorop, Pascanus Lp, Faldi Yaputra, Jimmy Fa Barus, and I Putu Eka Widyadharma. "THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN." International Journal of Medical Reviews and Case Reports 2.3 (2018), 58-61. Print. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

APA (American Psychological Association) Style

Togatorop, P. L., Yaputra, . F. ., Barus, . J. F. & Widyadharma, . I. P. . E. (2018) THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. International Journal of Medical Reviews and Case Reports, 2 (3), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

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