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Case Report

Online Publishing Date:
08 / 08 / 2022

 


Malignant phyllodes with bilateral leydig cell hyperplasia of testes in a case of complete androgen insensitivity syndrome- A rare case report

Sanjay Bijwe, Ashwini Natekar, Shweta Watane, Kavita Pawar, Nitin Sagare.


Abstract
Background: Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens. Individuals with complete androgen insensitivity syndrome are born phenotypically female, without any signs of genital masculinization, despite having a 46, XY karyotype.
Case report:
We present a case of a 66 year nulliparous female with primary amenorrhea with complaints of bilateral inguinal mass for 5 years and bilateral breast lump for 3 years. The patient developed a sudden increase in the size of a left breast lump. An MRI chest revealed a large 15.4x11.5cm heterogeneous mass in the left breast and a 9.9x6.1 cm lobulated mass in the right breast. MRI abdomen and pelvis revealed soft tissue structures in the bilateral inguinal region near the deep inguinal ring with a blind-ending vaginal tract and absent uterus and ovaries. karyotyping revealed 46XY. We received specimens of left MRM, right lumpectomy and bilateral inguinal mass. Left MRM measured 32x20x12cm. The cut section showed a large tumour with a variegated appearance. The right lumpectomy showed a tumour with a leaf-like appearance noted. The bilateral inguinal mass measured 5x3x3 cm each; the cut section showed yellowish nodules. Histopathological examination reveals malignant phyllodes of the left breast, benign phyllodes of the right breast, and Leydig cell hyperplasia of bilateral testes. Conclusion:
This is the first case reported of malignant phyllodes in a case of complete androgen insensitivity syndrome with bilateral Leydig cell hyperplasia of testes.

Key words: malignant phyllodes, CAIS, leydig cell hyperplasia


 
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How to Cite this Article
Pubmed Style

Bijwe S, Natekar A, Watane S, Pawar K, Sagare N. Malignant phyllodes with bilateral leydig cell hyperplasia of testes in a case of complete androgen insensitivity syndrome- A rare case report. Int J Med Rev Case Rep. 2022; 6(13): 45-48. doi:10.5455/IJMRCR.172-1643859051

Web Style

Bijwe S, Natekar A, Watane S, Pawar K, Sagare N. Malignant phyllodes with bilateral leydig cell hyperplasia of testes in a case of complete androgen insensitivity syndrome- A rare case report. https://www.mdpub.net/?mno=25002 [Access: April 04, 2024]. doi:10.5455/IJMRCR.172-1643859051

AMA (American Medical Association) Style

Bijwe S, Natekar A, Watane S, Pawar K, Sagare N. Malignant phyllodes with bilateral leydig cell hyperplasia of testes in a case of complete androgen insensitivity syndrome- A rare case report. Int J Med Rev Case Rep. 2022; 6(13): 45-48. doi:10.5455/IJMRCR.172-1643859051


Vancouver/ICMJE Style

Bijwe S, Natekar A, Watane S, Pawar K, Sagare N. Malignant phyllodes with bilateral leydig cell hyperplasia of testes in a case of complete androgen insensitivity syndrome- A rare case report. Int J Med Rev Case Rep. (2022), [cited April 04, 2024]; 6(13): 45-48. doi:10.5455/IJMRCR.172-1643859051


Harvard Style

Bijwe, S., Natekar, . A., Watane, . S., Pawar, . K. & Sagare, . N. (2022) Malignant phyllodes with bilateral leydig cell hyperplasia of testes in a case of complete androgen insensitivity syndrome- A rare case report. Int J Med Rev Case Rep, 6 (13), 45-48. doi:10.5455/IJMRCR.172-1643859051


Turabian Style

Bijwe, Sanjay, Ashwini Natekar, Shweta Watane, Kavita Pawar, and Nitin Sagare. 2022. Malignant phyllodes with bilateral leydig cell hyperplasia of testes in a case of complete androgen insensitivity syndrome- A rare case report. International Journal of Medical Reviews and Case Reports, 6 (13), 45-48. doi:10.5455/IJMRCR.172-1643859051


Chicago Style

Bijwe, Sanjay, Ashwini Natekar, Shweta Watane, Kavita Pawar, and Nitin Sagare. "Malignant phyllodes with bilateral leydig cell hyperplasia of testes in a case of complete androgen insensitivity syndrome- A rare case report." International Journal of Medical Reviews and Case Reports 6 (2022), 45-48. doi:10.5455/IJMRCR.172-1643859051


MLA (The Modern Language Association) Style

Bijwe, Sanjay, Ashwini Natekar, Shweta Watane, Kavita Pawar, and Nitin Sagare. "Malignant phyllodes with bilateral leydig cell hyperplasia of testes in a case of complete androgen insensitivity syndrome- A rare case report." International Journal of Medical Reviews and Case Reports 6.13 (2022), 45-48. Print. doi:10.5455/IJMRCR.172-1643859051


APA (American Psychological Association) Style

Bijwe, S., Natekar, . A., Watane, . S., Pawar, . K. & Sagare, . N. (2022) Malignant phyllodes with bilateral leydig cell hyperplasia of testes in a case of complete androgen insensitivity syndrome- A rare case report. International Journal of Medical Reviews and Case Reports, 6 (13), 45-48. doi:10.5455/IJMRCR.172-1643859051


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