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Review Article
Online Published: 28 Mar 2021
 


Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations

Barbara Arajo de Figueiredo Toledo, Isadora Silva dos Anjos, Julia Teoro Mansano, Leticia Dias Escoura, Raianny Cunha Duarte, Douglas Reis Abdalla.


Abstract
COVID-19 has already affected more than 34 million people and led to the death of 1 million of them. The most serious cases that lead to death usually occur in people with comorbidities such as obesity, hypertension and diabetes. However, it has been observed that children with COVID-19 later show signs and symptoms that resemble Kawasaki's Disease (DK). The present study aims to recruit evidence about the relation of COVID-19 as a triggering factor for manifestations of DK, especially vasculitis. Infection with the SARS-COV-2 virus can both mimic DK symptoms, since an excessive immune response to the virus is capable of stimulating interferons and the STING pathway, which triggers exacerbated immune responses, decreased lymphocytes, increased B and T cell responses, and increased monocytes secreting cytotoxins, facts that corroborate the characteristic vasculitis of DK. Therefore, there is no concrete scientific evidence/ evidence of the association between the diseases, however, factors have been discussed that suggest that the SARS-COV-2 virus may be a trigger for Kawasaki-like vasculitis in children, reported in several countries in the COVID-19 pandemic.

Key words: Kawasaki’s Disease, SARS-COV-2, Vasculitis, Child


 
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How to Cite this Article
Pubmed Style

Toledo BAdF, Anjos ISd, Mansano JT, Escoura LD, Duarte RC, Abdalla DR. Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations. Int J Med Rev Case Rep. 2021; 5(2): 48-55. doi:10.5455/IJMRCR.kawasaki-disease-172-1608317692

Web Style

Toledo BAdF, Anjos ISd, Mansano JT, Escoura LD, Duarte RC, Abdalla DR. Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations. https://www.mdpub.net/?mno=32420 [Access: October 13, 2024]. doi:10.5455/IJMRCR.kawasaki-disease-172-1608317692

AMA (American Medical Association) Style

Toledo BAdF, Anjos ISd, Mansano JT, Escoura LD, Duarte RC, Abdalla DR. Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations. Int J Med Rev Case Rep. 2021; 5(2): 48-55. doi:10.5455/IJMRCR.kawasaki-disease-172-1608317692


Vancouver/ICMJE Style

Toledo BAdF, Anjos ISd, Mansano JT, Escoura LD, Duarte RC, Abdalla DR. Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations. Int J Med Rev Case Rep. (2021), [cited October 13, 2024]; 5(2): 48-55. doi:10.5455/IJMRCR.kawasaki-disease-172-1608317692


Harvard Style

Toledo, B. A. d. F., Anjos, . I. S. d., Mansano, . J. T., Escoura, . L. D., Duarte, . R. C. & Abdalla, . D. R. (2021) Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations. Int J Med Rev Case Rep, 5 (2), 48-55. doi:10.5455/IJMRCR.kawasaki-disease-172-1608317692


Turabian Style

Toledo, Barbara Arajo de Figueiredo, Isadora Silva dos Anjos, Julia Teoro Mansano, Leticia Dias Escoura, Raianny Cunha Duarte, and Douglas Reis Abdalla. 2021. Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations. International Journal of Medical Reviews and Case Reports, 5 (2), 48-55. doi:10.5455/IJMRCR.kawasaki-disease-172-1608317692


Chicago Style

Toledo, Barbara Arajo de Figueiredo, Isadora Silva dos Anjos, Julia Teoro Mansano, Leticia Dias Escoura, Raianny Cunha Duarte, and Douglas Reis Abdalla. "Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations." International Journal of Medical Reviews and Case Reports 5 (2021), 48-55. doi:10.5455/IJMRCR.kawasaki-disease-172-1608317692


MLA (The Modern Language Association) Style

Toledo, Barbara Arajo de Figueiredo, Isadora Silva dos Anjos, Julia Teoro Mansano, Leticia Dias Escoura, Raianny Cunha Duarte, and Douglas Reis Abdalla. "Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations." International Journal of Medical Reviews and Case Reports 5.2 (2021), 48-55. Print. doi:10.5455/IJMRCR.kawasaki-disease-172-1608317692


APA (American Psychological Association) Style

Toledo, B. A. d. F., Anjos, . I. S. d., Mansano, . J. T., Escoura, . L. D., Duarte, . R. C. & Abdalla, . D. R. (2021) Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations. International Journal of Medical Reviews and Case Reports, 5 (2), 48-55. doi:10.5455/IJMRCR.kawasaki-disease-172-1608317692


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