Purpura vasculaire, hémorragie alvéolaire : Penser aux effets secondaires du Rituximab

Naoual Oubelkacem; Maha 0uazzani; Noufissa Alami; Zineb Khammar; Rhizlane Berrady

doi:10.5455/IJMRCR.172-1651785236

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Case Report
Online Published: 22 Aug 2022

Int J Med Rev Case Rep. 2022; 6(14): 40-43

doi: 10.5455/IJMRCR.172-1651785236

Purpura vasculaire, hémorragie alvéolaire : Penser aux effets secondaires du Rituximab

Naoual Oubelkacem, Maha 0uazzani, Noufissa Alami, Zineb Khammar, Rhizlane Berrady.

Abstract
Résumé :
Le Rituximab est un anticorps monoclonal anti-CD20 indiqué dans les lymphomes non hodgkiniens, la leucémie lymphoïde chronique et la polyarthrite rhumatoïde réfractaire, mais aussi largement utilisé dans les maladies auto-immunes ; il a changé le pronostic et l’évolution de ces maladies, aux dépens d’effets secondaires, parfois graves. Nous rapportons à travers cette observation, le cas d’une patiente suivie pour un syndrome des anti-synthétases réfractaire, et qui a développé un purpura vasculaire associée à une hémorragie alvéolaire après la perfusion de Rituximab, avec une bonne évolution clinique et radiologique après arrêt du traitement et sous corticothérapie.
Summary :
Rituximab is an anti-CD20 monoclonal antibody indicated in non-Hodgkin’s lymphoma, chronic lymphocytic leukaemia and refractory rheumatoid arthritis, but also widely used in auto-immunes; it has changed the prognosis and evolution of these diseases, at the expense of side effects, sometimes serious. We report through this observation, the case of a patient followed for a refractory anti-synthetase syndrome and who developed vascular purpura associated with alveolar haemorrhage after infusion of Rituximab, with good clinical and radiological progress after discontinuation of treatment and corticosteroid therapy.

Key words: rituximab, hémorragie alvéolaire, purpura vasculaire

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How to Cite this Article

Pubmed Style

Oubelkacem N, uazzani M, Alami N, Khammar Z, Berrady R. Purpura vasculaire, hémorragie alvéolaire : Penser aux effets secondaires du Rituximab. Int J Med Rev Case Rep. 2022; 6(14): 40-43. doi:10.5455/IJMRCR.172-1651785236

Web Style

Oubelkacem N, uazzani M, Alami N, Khammar Z, Berrady R. Purpura vasculaire, hémorragie alvéolaire : Penser aux effets secondaires du Rituximab. https://www.mdpub.net/?mno=32810 [Access: October 13, 2024]. doi:10.5455/IJMRCR.172-1651785236

AMA (American Medical Association) Style

Oubelkacem N, uazzani M, Alami N, Khammar Z, Berrady R. Purpura vasculaire, hémorragie alvéolaire : Penser aux effets secondaires du Rituximab. Int J Med Rev Case Rep. 2022; 6(14): 40-43. doi:10.5455/IJMRCR.172-1651785236

Vancouver/ICMJE Style

Oubelkacem N, uazzani M, Alami N, Khammar Z, Berrady R. Purpura vasculaire, hémorragie alvéolaire : Penser aux effets secondaires du Rituximab. Int J Med Rev Case Rep. (2022), [cited October 13, 2024]; 6(14): 40-43. doi:10.5455/IJMRCR.172-1651785236

Harvard Style

Oubelkacem, N., uazzani, . M., Alami, . N., Khammar, . Z. & Berrady, . R. (2022) Purpura vasculaire, hémorragie alvéolaire : Penser aux effets secondaires du Rituximab. Int J Med Rev Case Rep, 6 (14), 40-43. doi:10.5455/IJMRCR.172-1651785236

Turabian Style

Oubelkacem, Naoual, Maha uazzani, Noufissa Alami, Zineb Khammar, and Rhizlane Berrady. 2022. Purpura vasculaire, hémorragie alvéolaire : Penser aux effets secondaires du Rituximab. International Journal of Medical Reviews and Case Reports, 6 (14), 40-43. doi:10.5455/IJMRCR.172-1651785236

Chicago Style

Oubelkacem, Naoual, Maha uazzani, Noufissa Alami, Zineb Khammar, and Rhizlane Berrady. "Purpura vasculaire, hémorragie alvéolaire : Penser aux effets secondaires du Rituximab." International Journal of Medical Reviews and Case Reports 6 (2022), 40-43. doi:10.5455/IJMRCR.172-1651785236

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Oubelkacem, N., uazzani, . M., Alami, . N., Khammar, . Z. & Berrady, . R. (2022) Purpura vasculaire, hémorragie alvéolaire : Penser aux effets secondaires du Rituximab. International Journal of Medical Reviews and Case Reports, 6 (14), 40-43. doi:10.5455/IJMRCR.172-1651785236

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