Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar

Dodo Saputera Damian; Erwin Arief; Syakib Bakri; Fachruddin Benyamin; Makbul Aman; Hasyim Kasim; Harun Iskandar; Arifin Seweng

doi:10.5455/IJMRCR.pulmonary-tuberculosis

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Original Article
Online Published: 29 Sep 2019

Int J Med Rev Case Rep. 2019; 3(11): 693-696

doi: 10.5455/IJMRCR.pulmonary-tuberculosis

Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar

Dodo Saputera Damian , Erwin Arief, Syakib Bakri, Fachruddin Benyamin, Makbul Aman, Hasyim Kasim, Harun Iskandar, Arifin Seweng.

Abstract
Background: Tuberculosis is an infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis.[1] C-reactive protein is acute phase reactants that increase during inflammatory process occurs in the body. Mycobacterium tuberculosis enters body, causes inflammation and releases various pro-inflammatory cytokines, mainly interleukin 8 and interleukin 6.[2] Increased plasma concentration of interleukin 6 stimulates increased C-reactive protein synthesis by hepatocyte cells in the liver.[4] Objective: Determined the correlation between C-reactive protein levels with Acid-Fast Bacilli smear positivity and extent of chest X-ray lesions in new Pulmonary Tuberculosis patients with positive Acid-Fast Bacilli smear. Methods: The study design was an analytical study with an observational prospective cohort. The subjects of the study were 50 subjects with new case pulmonary tuberculosis positive smear who were examined for AFB smear, chest X-ray, C-reactive protein levels before and after intensive phase treatment. Results: C-reactive protein levels were significantly higher (p<0,05) in pulmonary tuberculosis subjects with advanced lesions (6,31+3,34) compared to minimal lesions (3,20+3,16). Based on Acid-Fast Bacilli smear positivity, the highest C-reactive protein levels were obtained in pulmonary tuberculosis samples with Acid-Fast Bacilli +2 (7,20+3,01). There was a significant reduction in C-reactive protein levels (69,6%) after 2 months intensive phase treatment. Conclusions: C-reactive protein levels before treatment are significantly associated with extent of chest X-Ray lesions and Acid-Fast Bacilli smear positivity, so that can be used as a marker of severity of pulmonary tuberculosis disease. There are significant reduction in C-reactive protein levels after intensive phase treatment.

Key words: Pulmonary tuberculosis, Acid-Fast Bacilli smear, C-reactive Protein

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How to Cite this Article

Pubmed Style

DSD, Arief E, Bakri S, Benyamin F, Aman M, Kasim H, Iskandar H, Seweng A, . Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar. Int J Med Rev Case Rep. 2019; 3(11): 693-696. doi:10.5455/IJMRCR.pulmonary-tuberculosis

Web Style

DSD, Arief E, Bakri S, Benyamin F, Aman M, Kasim H, Iskandar H, Seweng A, . Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar. https://www.mdpub.net/?mno=38020 [Access: October 13, 2024]. doi:10.5455/IJMRCR.pulmonary-tuberculosis

AMA (American Medical Association) Style

DSD, Arief E, Bakri S, Benyamin F, Aman M, Kasim H, Iskandar H, Seweng A, . Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar. Int J Med Rev Case Rep. 2019; 3(11): 693-696. doi:10.5455/IJMRCR.pulmonary-tuberculosis

Vancouver/ICMJE Style

DSD, Arief E, Bakri S, Benyamin F, Aman M, Kasim H, Iskandar H, Seweng A, . Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar. Int J Med Rev Case Rep. (2019), [cited October 13, 2024]; 3(11): 693-696. doi:10.5455/IJMRCR.pulmonary-tuberculosis

Harvard Style

, D. S. D., Arief, E., Bakri, S., Benyamin, F., Aman, M., Kasim, H., Iskandar, H., Seweng, A. & (2019) Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar. Int J Med Rev Case Rep, 3 (11), 693-696. doi:10.5455/IJMRCR.pulmonary-tuberculosis

Turabian Style

, Dodo Saputera Damian, Erwin Arief, Syakib Bakri, Fachruddin Benyamin, Makbul Aman, Hasyim Kasim, Harun Iskandar, Arifin Seweng, and . 2019. Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar. International Journal of Medical Reviews and Case Reports, 3 (11), 693-696. doi:10.5455/IJMRCR.pulmonary-tuberculosis

Chicago Style

, Dodo Saputera Damian, Erwin Arief, Syakib Bakri, Fachruddin Benyamin, Makbul Aman, Hasyim Kasim, Harun Iskandar, Arifin Seweng, and . "Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar." International Journal of Medical Reviews and Case Reports 3 (2019), 693-696. doi:10.5455/IJMRCR.pulmonary-tuberculosis

MLA (The Modern Language Association) Style

, Dodo Saputera Damian, Erwin Arief, Syakib Bakri, Fachruddin Benyamin, Makbul Aman, Hasyim Kasim, Harun Iskandar, Arifin Seweng, and . "Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar." International Journal of Medical Reviews and Case Reports 3.11 (2019), 693-696. Print. doi:10.5455/IJMRCR.pulmonary-tuberculosis

APA (American Psychological Association) Style

, D. S. D., Arief, E., Bakri, S., Benyamin, F., Aman, M., Kasim, H., Iskandar, H., Seweng, A. & (2019) Correlation between C-reactive protein concentration with disease severity in new case pulmonary tuberculosis with positive smear patients in Makassar. International Journal of Medical Reviews and Case Reports, 3 (11), 693-696. doi:10.5455/IJMRCR.pulmonary-tuberculosis

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