E-ISSN 2534-9821
 

Case Report 


A Cervical Carcinoma Patient with Therapy-related Myeloid Neoplasm after Chemotherapy and Radiotherapy

Komang Agus Wira Nugraha, Ni Made Renny Anggreni Rena, Herman Saputra.

Abstract
The quantity of cancer survivors in developed countries has tripled since 1970 and is growing by 2% each year. The 5-year survival rate of cancer patients is about 66% and in 2004 there were 10 million cancer survivors in the United States. Due to improvements in early detection and treatment, the quantity of patients with multiple cancers is rapidly growing. The rapid improvement of cancer treatment (chemotherapy or radiotherapy) will increase the side effects, such as the emergence of other types of malignancies. Therapy-related myeloid neoplasm (t-MN) consists of therapy-related acute myeloid leukaemia (t-AML) and therapy-related myelodysplastic syndrome (t-MDS). This type of malignancy is raised after treatment with chemotherapy, radiotherapy, immunosuppressive agents, or after documented exposure to environmental carcinogens. We report the case of 49 years old woman with cervical cancer. She was treated by chemotherapy (paclitaxel, carboplatin) and radiotherapy. After about 4 years of initial chemotherapy, she was diagnosed with t-MN (t-AML). Based on the timeline of the event in our patient, we strongly suspected carboplatin, paclitaxel, and radiotherapy as the culprit in the pathogenesis of this myeloid neoplasm. After incomplete induction chemotherapy, she passed away following suspicion of pulmonary leukostasis and septic shock.

Key words: therapy-related myeloid neoplasm, chemotherapy, radiotherapy


 
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How to Cite this Article
Pubmed Style

Nugraha KAW, Rena NMRA, Saputra H. A Cervical Carcinoma Patient with Therapy-related Myeloid Neoplasm after Chemotherapy and Radiotherapy. Int J Med Rev Case Rep. 2022; 6(2): 53-59. doi:10.5455/IJMRCR.CervicalCarcinomaPatientwithTherapy-relatedMyeloidNeoplasm


Web Style

Nugraha KAW, Rena NMRA, Saputra H. A Cervical Carcinoma Patient with Therapy-related Myeloid Neoplasm after Chemotherapy and Radiotherapy. https://www.mdpub.net/?mno=5375 [Access: January 14, 2023]. doi:10.5455/IJMRCR.CervicalCarcinomaPatientwithTherapy-relatedMyeloidNeoplasm


AMA (American Medical Association) Style

Nugraha KAW, Rena NMRA, Saputra H. A Cervical Carcinoma Patient with Therapy-related Myeloid Neoplasm after Chemotherapy and Radiotherapy. Int J Med Rev Case Rep. 2022; 6(2): 53-59. doi:10.5455/IJMRCR.CervicalCarcinomaPatientwithTherapy-relatedMyeloidNeoplasm



Vancouver/ICMJE Style

Nugraha KAW, Rena NMRA, Saputra H. A Cervical Carcinoma Patient with Therapy-related Myeloid Neoplasm after Chemotherapy and Radiotherapy. Int J Med Rev Case Rep. (2022), [cited January 14, 2023]; 6(2): 53-59. doi:10.5455/IJMRCR.CervicalCarcinomaPatientwithTherapy-relatedMyeloidNeoplasm



Harvard Style

Nugraha, K. A. W., Rena, . N. M. R. A. & Saputra, . H. (2022) A Cervical Carcinoma Patient with Therapy-related Myeloid Neoplasm after Chemotherapy and Radiotherapy. Int J Med Rev Case Rep, 6 (2), 53-59. doi:10.5455/IJMRCR.CervicalCarcinomaPatientwithTherapy-relatedMyeloidNeoplasm



Turabian Style

Nugraha, Komang Agus Wira, Ni Made Renny Anggreni Rena, and Herman Saputra. 2022. A Cervical Carcinoma Patient with Therapy-related Myeloid Neoplasm after Chemotherapy and Radiotherapy. International Journal of Medical Reviews and Case Reports, 6 (2), 53-59. doi:10.5455/IJMRCR.CervicalCarcinomaPatientwithTherapy-relatedMyeloidNeoplasm



Chicago Style

Nugraha, Komang Agus Wira, Ni Made Renny Anggreni Rena, and Herman Saputra. "A Cervical Carcinoma Patient with Therapy-related Myeloid Neoplasm after Chemotherapy and Radiotherapy." International Journal of Medical Reviews and Case Reports 6 (2022), 53-59. doi:10.5455/IJMRCR.CervicalCarcinomaPatientwithTherapy-relatedMyeloidNeoplasm



MLA (The Modern Language Association) Style

Nugraha, Komang Agus Wira, Ni Made Renny Anggreni Rena, and Herman Saputra. "A Cervical Carcinoma Patient with Therapy-related Myeloid Neoplasm after Chemotherapy and Radiotherapy." International Journal of Medical Reviews and Case Reports 6.2 (2022), 53-59. Print. doi:10.5455/IJMRCR.CervicalCarcinomaPatientwithTherapy-relatedMyeloidNeoplasm



APA (American Psychological Association) Style

Nugraha, K. A. W., Rena, . N. M. R. A. & Saputra, . H. (2022) A Cervical Carcinoma Patient with Therapy-related Myeloid Neoplasm after Chemotherapy and Radiotherapy. International Journal of Medical Reviews and Case Reports, 6 (2), 53-59. doi:10.5455/IJMRCR.CervicalCarcinomaPatientwithTherapy-relatedMyeloidNeoplasm