E-ISSN 2534-9821
 

Original Research 


Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus

Pande Ketut Kurniari, I Putu Bayu Triguna, Gede Kambayana, Tjokorda Raka Putra.

Abstract
Introduction: Osteoporosis often occurred in SLE patients, one of the mechanisms involved increased homocysteine levels and oxidative stress. Homocysteine levels greatly affect osteoclast and osteoblast activity. Two crucial proteins are produced by osteoblasts; namely the RANKL activator and OPG receptor.
Purpose: This study aims to prove that there is a relationship between serum homocysteine and osteoprotegerin (OPG) levels and bone mineral density in women with systemic lupus erythematosus.
Method: A cross-sectional analytic study with a sample size of 66 females with SLE age 18-50 years. The research variables were age, duration of illness, cumulative dose of corticosteroids, GFR, through interviews and review of medical records. Examination of RANKL and OPG serum by ELISA. BMD examination by Dual Energy X-ray Absorptiometry (DEXA).
Result : A total of 66 female subjects with a mean age of 30.67 ± 8.27 years were included in this study. In bivariate analysis, homocysteine levels had a significant correlation with BMD (r = - 0.250, p = 0.021), serum OPG (r = -0.468, p = 0.000), and serum RANKL (r = -0.368, p = 0.001) . In the multiple linear regression test, the formula for the regression equation is y = 0.1x + (- 4).
Conclusion: The results between homocysteine and OPG levels show an inverse correlation, where the higher the homocysteine level, the lower the serum OPG.

Key words: SLE, Homocysteine, BMD, RANKL, OPG


 
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How to Cite this Article
Pubmed Style

Kurniari PK, Triguna IPB, Kambayana G, Putra TR. Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus. Int J Med Rev Case Rep. 2022; 6(2): 91-95. doi:10.5455/IJMRCR.CorrelationbetweenhomocysteineandosteoprotegerinOPGserum


Web Style

Kurniari PK, Triguna IPB, Kambayana G, Putra TR. Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus. https://www.mdpub.net/?mno=74350 [Access: January 14, 2023]. doi:10.5455/IJMRCR.CorrelationbetweenhomocysteineandosteoprotegerinOPGserum


AMA (American Medical Association) Style

Kurniari PK, Triguna IPB, Kambayana G, Putra TR. Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus. Int J Med Rev Case Rep. 2022; 6(2): 91-95. doi:10.5455/IJMRCR.CorrelationbetweenhomocysteineandosteoprotegerinOPGserum



Vancouver/ICMJE Style

Kurniari PK, Triguna IPB, Kambayana G, Putra TR. Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus. Int J Med Rev Case Rep. (2022), [cited January 14, 2023]; 6(2): 91-95. doi:10.5455/IJMRCR.CorrelationbetweenhomocysteineandosteoprotegerinOPGserum



Harvard Style

Kurniari, P. K., Triguna, . I. P. B., Kambayana, . G. & Putra, . T. R. (2022) Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus. Int J Med Rev Case Rep, 6 (2), 91-95. doi:10.5455/IJMRCR.CorrelationbetweenhomocysteineandosteoprotegerinOPGserum



Turabian Style

Kurniari, Pande Ketut, I Putu Bayu Triguna, Gede Kambayana, and Tjokorda Raka Putra. 2022. Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus. International Journal of Medical Reviews and Case Reports, 6 (2), 91-95. doi:10.5455/IJMRCR.CorrelationbetweenhomocysteineandosteoprotegerinOPGserum



Chicago Style

Kurniari, Pande Ketut, I Putu Bayu Triguna, Gede Kambayana, and Tjokorda Raka Putra. "Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus." International Journal of Medical Reviews and Case Reports 6 (2022), 91-95. doi:10.5455/IJMRCR.CorrelationbetweenhomocysteineandosteoprotegerinOPGserum



MLA (The Modern Language Association) Style

Kurniari, Pande Ketut, I Putu Bayu Triguna, Gede Kambayana, and Tjokorda Raka Putra. "Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus." International Journal of Medical Reviews and Case Reports 6.2 (2022), 91-95. Print. doi:10.5455/IJMRCR.CorrelationbetweenhomocysteineandosteoprotegerinOPGserum



APA (American Psychological Association) Style

Kurniari, P. K., Triguna, . I. P. B., Kambayana, . G. & Putra, . T. R. (2022) Correlation between homocysteine and osteoprotegerin (OPG) serum with bone mineral density in women with systemic lupus erythematosus. International Journal of Medical Reviews and Case Reports, 6 (2), 91-95. doi:10.5455/IJMRCR.CorrelationbetweenhomocysteineandosteoprotegerinOPGserum