Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report

Sonia Silva; Francisca Costa; Claudia Teles Silva; Tiago Parreira; Mafalda Sampaio; Raquel Sousa

doi:10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

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Brief Report
Online Published: 04 Feb 2020

Int J Med Rev Case Rep. 2020; 4(4): 84-87

doi: 10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report

Sonia Silva, Francisca Costa, Claudia Teles Silva, Tiago Parreira, Mafalda Sampaio, Raquel Sousa.

Abstract
Mild encephalopathy with reversible splenial lesion (MERS) is a clinico-radiological syndrome characterized by a transient mild encephalopathy and magnetic resonance imaging findings of a reversible lesion in the splenium of corpus callosum. This syndrome is more frequently described in Asiatic population and has been associated with some viral and bacterial infections, including Influenza. In those cases, patients usually present with flu-like symptoms before the beginning of neurological symptoms.
We present a case report of an Influenza A-related MERS in a pediatric patient. He is an eleven year-old Caucasian male that presented with sudden abnormal behaviour and speech impairment, motor aphasia and dysarthria and episodic dystonic movements of his left upper limb. Brain CT and CT angiography were normal, but brain MRI demonstrated increased signals of restricted diffusion involving the corpus callosum and symmetrical extension to frontoparietal subcortical white matter. There was history of flu symptoms some days before and Influenza A was isolated on nasopharyngeal swab exam.
Neurological symptoms in MERS can be very variable, mainly in pediatric population. Clinicians should be aware of this disorder and include it in the differential diagnosis of encephalopathic patients, particularly during Influenza season. Prognosis is usually favourable with complete neurological and radiological resolution within days or weeks, as seen in our patient.

Key words: Influenza A, Encephalopathy, Mild Encephalopathy with Reversible Splenial lesion, Central Nervous System Infection, Corpus Callosum, Pediatrics

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How to Cite this Article

Pubmed Style

Silva S, Costa F, Silva CT, Parreira T, Sampaio M, Sousa R. Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report. Int J Med Rev Case Rep. 2020; 4(4): 84-87. doi:10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

Web Style

Silva S, Costa F, Silva CT, Parreira T, Sampaio M, Sousa R. Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report. https://www.mdpub.net/?mno=80720 [Access: April 02, 2025]. doi:10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

AMA (American Medical Association) Style

Silva S, Costa F, Silva CT, Parreira T, Sampaio M, Sousa R. Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report. Int J Med Rev Case Rep. 2020; 4(4): 84-87. doi:10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

Vancouver/ICMJE Style

Silva S, Costa F, Silva CT, Parreira T, Sampaio M, Sousa R. Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report. Int J Med Rev Case Rep. (2020), [cited April 02, 2025]; 4(4): 84-87. doi:10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

Harvard Style

Silva, S., Costa, . F., Silva, . C. T., Parreira, . T., Sampaio, . M. & Sousa, . R. (2020) Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report. Int J Med Rev Case Rep, 4 (4), 84-87. doi:10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

Turabian Style

Silva, Sonia, Francisca Costa, Claudia Teles Silva, Tiago Parreira, Mafalda Sampaio, and Raquel Sousa. 2020. Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report. International Journal of Medical Reviews and Case Reports, 4 (4), 84-87. doi:10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

Chicago Style

Silva, Sonia, Francisca Costa, Claudia Teles Silva, Tiago Parreira, Mafalda Sampaio, and Raquel Sousa. "Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report." International Journal of Medical Reviews and Case Reports 4 (2020), 84-87. doi:10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

MLA (The Modern Language Association) Style

Silva, Sonia, Francisca Costa, Claudia Teles Silva, Tiago Parreira, Mafalda Sampaio, and Raquel Sousa. "Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report." International Journal of Medical Reviews and Case Reports 4.4 (2020), 84-87. Print. doi:10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

APA (American Psychological Association) Style

Silva, S., Costa, . F., Silva, . C. T., Parreira, . T., Sampaio, . M. & Sousa, . R. (2020) Mild encephalopathy with reversible splenial lesion (MERS) duo to Influenza A: Case Report. International Journal of Medical Reviews and Case Reports, 4 (4), 84-87. doi:10.5455/IJMRCR.Mild-encephalopathy-with-reversible-splenial-lesion

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