E-ISSN 2534-9821
 
2023, Vol: 7, Issue: 12
7 / 12Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Copyright Transfer Form

Original Research
Online Published: 24 Jan 2022
 


Oral drug challenge in drug hypersensivity reactions and its safety

Lorena Stella, Joana Soares, Adriana Ferreira, Fátima Praça, Jorge Romariz, Herculano Costa, Cludia Pedrosa.


Abstract
Introduction: Drug allergy is a common suspicion in pediatric age, although it is rarely confirmed. Considering its relevance in therapeutic decisions, the definitive diagnosis is important. The oral drug challenge (ODC) has a significant role both to confirm the diagnosis and to find safe alternative treatment options. Objectives: Characterize a pediatric population submitted to ODC in a level III hospital and evaluate the safety and need of a venous catheter. Materials and methods: Retrospective study that includes all oral drug challenge performed between January 2018 and December 2020, in patients younger than 18 years. Results: 186 ODC were performed during the study period, 85.5% were performed either to confirm or exclude the diagnosis and the remaining 14.5% were designed to choose a safe alternative regimen. The median age was 5 years. Personal history of atopy was positive in 24.3% of patients. Amoxicillin was the tested drug in 42.5% of the sample and amoxicillin associated with clavulanic acid in 22%. In 38% of cases the manifestations appeared within the first 24 hours. There were 2.1% (n=4) positive ODC and the drugs were amoxicillin (2 cases), paracetamol and ibuprofen. Conclusions: Alergy to drugs is rare in pediatric age, but its suspicion is common. Considering its relevance in therapeutic decisions, it is important to refer all suspected cases to diagnostic clarification. In our sample there was no record of any serious reaction, namely anaphylaxis, requiring iv medication. The oral drug challenge has an essential role in confirming or excluding hypersensitivity and is a safe procedure.

Key words: Allergy; drugs; hypersensitivity; oral challenge; safety


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Lorena Stella
Articles by Joana Soares
Articles by Adriana Ferreira
Articles by Fátima Praça
Articles by Jorge Romariz
Articles by Herculano Costa
Articles by Cludia Pedrosa
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Stella L, Soares J, Ferreira A, Praca F, Romariz J, Costa H, Pedrosa C. Oral drug challenge in drug hypersensivity reactions and its safety. Int J Med Rev Case Rep. 2022; 6(3): 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety

Web Style

Stella L, Soares J, Ferreira A, Praca F, Romariz J, Costa H, Pedrosa C. Oral drug challenge in drug hypersensivity reactions and its safety. https://www.mdpub.net/?mno=87719 [Access: April 02, 2025]. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety

AMA (American Medical Association) Style

Stella L, Soares J, Ferreira A, Praca F, Romariz J, Costa H, Pedrosa C. Oral drug challenge in drug hypersensivity reactions and its safety. Int J Med Rev Case Rep. 2022; 6(3): 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety


Vancouver/ICMJE Style

Stella L, Soares J, Ferreira A, Praca F, Romariz J, Costa H, Pedrosa C. Oral drug challenge in drug hypersensivity reactions and its safety. Int J Med Rev Case Rep. (2022), [cited April 02, 2025]; 6(3): 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety


Harvard Style

Stella, L., Soares, . J., Ferreira, . A., Praca, . F., Romariz, . J., Costa, . H. & Pedrosa, . C. (2022) Oral drug challenge in drug hypersensivity reactions and its safety. Int J Med Rev Case Rep, 6 (3), 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety


Turabian Style

Stella, Lorena, Joana Soares, Adriana Ferreira, Fátima Praca, Jorge Romariz, Herculano Costa, and Cludia Pedrosa. 2022. Oral drug challenge in drug hypersensivity reactions and its safety. International Journal of Medical Reviews and Case Reports, 6 (3), 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety


Chicago Style

Stella, Lorena, Joana Soares, Adriana Ferreira, Fátima Praca, Jorge Romariz, Herculano Costa, and Cludia Pedrosa. "Oral drug challenge in drug hypersensivity reactions and its safety." International Journal of Medical Reviews and Case Reports 6 (2022), 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety


MLA (The Modern Language Association) Style

Stella, Lorena, Joana Soares, Adriana Ferreira, Fátima Praca, Jorge Romariz, Herculano Costa, and Cludia Pedrosa. "Oral drug challenge in drug hypersensivity reactions and its safety." International Journal of Medical Reviews and Case Reports 6.3 (2022), 28-30. Print. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety


APA (American Psychological Association) Style

Stella, L., Soares, . J., Ferreira, . A., Praca, . F., Romariz, . J., Costa, . H. & Pedrosa, . C. (2022) Oral drug challenge in drug hypersensivity reactions and its safety. International Journal of Medical Reviews and Case Reports, 6 (3), 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About International Journal of Medical Reviews and Case Reports

International Journal of Medical Reviews and Case Reports  (Int J Med Rev Case Rep)ISSN: 2534-9821The International Journal of Medical Reviews and Ca ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Any correspondence, queries or additional requests for information on the manuscript submission process should be sent to the International Journal of Medical Reviews and Case Reports editorial office as follows:

Bulgarian Association of Young Surgeons (BAYS);

National Center of Public Health and Analyses (NCPHA), floor 2, office № 31,  Sofia 1431, Bulgaria.

inkov@journalmedica.com

Financial department is managed by International Sci Ink Press. 

It is a company registered in Bulgaria with registered no. 205414288 and registered address at 57 Antim I str., Vazrazhdane, Sofia, 1303, Bulgaria.

Tel: +359883427500