E-ISSN 2534-9821
 

Original Research 


Oral drug challenge in drug hypersensivity reactions and its safety

Lorena Stella , Joana Soares , Adriana Ferreira , Fátima Praça , Jorge Romariz, Herculano Costa, Cludia Pedrosa.

Abstract
Introduction: Drug allergy is a common suspicion in pediatric age, although it is rarely confirmed. Considering its relevance in therapeutic decisions, the definitive diagnosis is important. The oral drug challenge (ODC) has a significant role both to confirm the diagnosis and to find safe alternative treatment options. Objectives: Characterize a pediatric population submitted to ODC in a level III hospital and evaluate the safety and need of a venous catheter. Materials and methods: Retrospective study that includes all oral drug challenge performed between January 2018 and December 2020, in patients younger than 18 years. Results: 186 ODC were performed during the study period, 85.5% were performed either to confirm or exclude the diagnosis and the remaining 14.5% were designed to choose a safe alternative regimen. The median age was 5 years. Personal history of atopy was positive in 24.3% of patients. Amoxicillin was the tested drug in 42.5% of the sample and amoxicillin associated with clavulanic acid in 22%. In 38% of cases the manifestations appeared within the first 24 hours. There were 2.1% (n=4) positive ODC and the drugs were amoxicillin (2 cases), paracetamol and ibuprofen. Conclusions: Alergy to drugs is rare in pediatric age, but its suspicion is common. Considering its relevance in therapeutic decisions, it is important to refer all suspected cases to diagnostic clarification. In our sample there was no record of any serious reaction, namely anaphylaxis, requiring iv medication. The oral drug challenge has an essential role in confirming or excluding hypersensitivity and is a safe procedure.

Key words: Allergy; drugs; hypersensitivity; oral challenge; safety


 
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How to Cite this Article
Pubmed Style

LS, JS, AF, FP, Romariz J, Costa H, Pedrosa C, . Oral drug challenge in drug hypersensivity reactions and its safety. Int J Med Rev Case Rep. 2022; 6(3): 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety


Web Style

LS, JS, AF, FP, Romariz J, Costa H, Pedrosa C, . Oral drug challenge in drug hypersensivity reactions and its safety. https://www.mdpub.net/?mno=87719 [Access: November 20, 2022]. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety


AMA (American Medical Association) Style

LS, JS, AF, FP, Romariz J, Costa H, Pedrosa C, . Oral drug challenge in drug hypersensivity reactions and its safety. Int J Med Rev Case Rep. 2022; 6(3): 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety



Vancouver/ICMJE Style

LS, JS, AF, FP, Romariz J, Costa H, Pedrosa C, . Oral drug challenge in drug hypersensivity reactions and its safety. Int J Med Rev Case Rep. (2022), [cited November 20, 2022]; 6(3): 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety



Harvard Style

, L. S., , J. S., , A. F., , F. P., Romariz, J., Costa, H., Pedrosa, C. & (2022) Oral drug challenge in drug hypersensivity reactions and its safety. Int J Med Rev Case Rep, 6 (3), 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety



Turabian Style

, Lorena Stella, Joana Soares, Adriana Ferreira, Fátima Praca, Jorge Romariz, Herculano Costa, Cludia Pedrosa, and . 2022. Oral drug challenge in drug hypersensivity reactions and its safety. International Journal of Medical Reviews and Case Reports, 6 (3), 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety



Chicago Style

, Lorena Stella, Joana Soares, Adriana Ferreira, Fátima Praca, Jorge Romariz, Herculano Costa, Cludia Pedrosa, and . "Oral drug challenge in drug hypersensivity reactions and its safety." International Journal of Medical Reviews and Case Reports 6 (2022), 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety



MLA (The Modern Language Association) Style

, Lorena Stella, Joana Soares, Adriana Ferreira, Fátima Praca, Jorge Romariz, Herculano Costa, Cludia Pedrosa, and . "Oral drug challenge in drug hypersensivity reactions and its safety." International Journal of Medical Reviews and Case Reports 6.3 (2022), 28-30. Print. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety



APA (American Psychological Association) Style

, L. S., , J. S., , A. F., , F. P., Romariz, J., Costa, H., Pedrosa, C. & (2022) Oral drug challenge in drug hypersensivity reactions and its safety. International Journal of Medical Reviews and Case Reports, 6 (3), 28-30. doi:10.5455/IJMRCR.Oraldrugchallengeindrughypersensivityreactionsanditssafety