E-ISSN 2534-9821
 

Original Article 


Histomorphologic spectrum of Hodgkin and non-Hodgkin lymphomas according to WHO classification 2016 in a tertiary care hospital in Maharashtra

Kunda Arvind Jagadale, Milind Kesarkhane, Shashank Singh, Anuja Mohan Patil.

Abstract
Introduction: Lymphoma is a group of lymphoproliferative malignancies that can originate in B lymphocytes, T lymphocytes, or natural killer (NK) lymphocytes. They account for 3% of all cancer types. The WHO's 2008 World Health Organization (WHO) classification of hematopoietic and lymphoid tumours was refined in 2016. This study screened surgically excised or biopsied specimens for lymphoma in lymphadenopathy. This research aimed to classify lymphomas in India based on histopathological and immunohistochemical findings.
Methods: The study included 71 cases suspected/probable/proven to have lymphomas, and H&E-suggestive lymphoid malignancies were recruited. Clinical details, histopathological reports, and lymphoma panel IHC status were analyzed. Age, sex, biopsy site, B-symptom history, and clinical findings were recorded. Paraffin blocks were prepared from biopsy specimens in buffered formalin using standard automated methods. All cases' slides were examined to confirm lymphoma. Tissue blocks were selected for IHC staining. All the slides were evaluated and classified as per the WHO 2016 lymphoma classification.
Results: The mean age of the patients was 44.58 years; 54 patients were males, while 17 were females. 61 of 71 cases were detected to be of NHL, and 10 cases were of HL. Most NHL cases were formed by B cell neoplasms, constituting 72.1%, whereas T cell neoplasms constituted 24.6%. 2 of 61 cases showed CD56 positivity apart from T-cell markers and were categorized as T/NK cell NHL. As per WHO classification, different types of NHL and HL were classified. Among NHL, follicular lymphoma (FL) was predominant with 15 cases, while in CHL, mixed cellularity CHL prevalence was high. Ki67 expression in 15 cases of FL showed 1 case of grade 1, 3 cases of grade 2 and 2 cases of grade 3 follicular lymphoma with a Ki67 index of more than 40%.
Conclusion: Histomorphology and immunohistochemistry help diagnose lymphoma. NHL was more common among nodal and extranodal lymphomas. Men dominated the NHL and HL. Follicular lymphoma (FL) was the most common subtype of B-cell NHL. Most HL patients had mixed-cellularity CHL.

Key words: Lymphoma, Immunohistochemistry, Hodgkin’s lymphoma, non-Hodgkin’s lymphoma


 
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How to Cite this Article
Pubmed Style

Jagadale KA, Kesarkhane M, Singh S, Patil AM. Histomorphologic spectrum of Hodgkin and non-Hodgkin lymphomas according to WHO classification 2016 in a tertiary care hospital in Maharashtra. Int J Med Rev Case Rep. 2022; 6(22): 36-43. doi:10.5455/IJMRCR.172-1661421815


Web Style

Jagadale KA, Kesarkhane M, Singh S, Patil AM. Histomorphologic spectrum of Hodgkin and non-Hodgkin lymphomas according to WHO classification 2016 in a tertiary care hospital in Maharashtra. https://www.mdpub.net/?mno=109091 [Access: December 05, 2023]. doi:10.5455/IJMRCR.172-1661421815


AMA (American Medical Association) Style

Jagadale KA, Kesarkhane M, Singh S, Patil AM. Histomorphologic spectrum of Hodgkin and non-Hodgkin lymphomas according to WHO classification 2016 in a tertiary care hospital in Maharashtra. Int J Med Rev Case Rep. 2022; 6(22): 36-43. doi:10.5455/IJMRCR.172-1661421815



Vancouver/ICMJE Style

Jagadale KA, Kesarkhane M, Singh S, Patil AM. Histomorphologic spectrum of Hodgkin and non-Hodgkin lymphomas according to WHO classification 2016 in a tertiary care hospital in Maharashtra. Int J Med Rev Case Rep. (2022), [cited December 05, 2023]; 6(22): 36-43. doi:10.5455/IJMRCR.172-1661421815



Harvard Style

Jagadale, K. A., Kesarkhane, . M., Singh, . S. & Patil, . A. M. (2022) Histomorphologic spectrum of Hodgkin and non-Hodgkin lymphomas according to WHO classification 2016 in a tertiary care hospital in Maharashtra. Int J Med Rev Case Rep, 6 (22), 36-43. doi:10.5455/IJMRCR.172-1661421815



Turabian Style

Jagadale, Kunda Arvind, Milind Kesarkhane, Shashank Singh, and Anuja Mohan Patil. 2022. Histomorphologic spectrum of Hodgkin and non-Hodgkin lymphomas according to WHO classification 2016 in a tertiary care hospital in Maharashtra. International Journal of Medical Reviews and Case Reports, 6 (22), 36-43. doi:10.5455/IJMRCR.172-1661421815



Chicago Style

Jagadale, Kunda Arvind, Milind Kesarkhane, Shashank Singh, and Anuja Mohan Patil. "Histomorphologic spectrum of Hodgkin and non-Hodgkin lymphomas according to WHO classification 2016 in a tertiary care hospital in Maharashtra." International Journal of Medical Reviews and Case Reports 6 (2022), 36-43. doi:10.5455/IJMRCR.172-1661421815



MLA (The Modern Language Association) Style

Jagadale, Kunda Arvind, Milind Kesarkhane, Shashank Singh, and Anuja Mohan Patil. "Histomorphologic spectrum of Hodgkin and non-Hodgkin lymphomas according to WHO classification 2016 in a tertiary care hospital in Maharashtra." International Journal of Medical Reviews and Case Reports 6.22 (2022), 36-43. Print. doi:10.5455/IJMRCR.172-1661421815



APA (American Psychological Association) Style

Jagadale, K. A., Kesarkhane, . M., Singh, . S. & Patil, . A. M. (2022) Histomorphologic spectrum of Hodgkin and non-Hodgkin lymphomas according to WHO classification 2016 in a tertiary care hospital in Maharashtra. International Journal of Medical Reviews and Case Reports, 6 (22), 36-43. doi:10.5455/IJMRCR.172-1661421815