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Review Article
Online Published: 16 Aug 2020
 


The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review

Putri Rossyana Dewi, I Putu Eka Widyadharma, I Made Oka Adnyana, Desak Made Wihandani.


Abstract
Pain is one of the health problems that really common in the field of medicine. Complaints of pain themselves are subjective and can affect the quality of life of patients. Therefore, a good understanding is needed to be able to diagnose and treat pain comprehensively. Along with the changing lifestyle in the community, the prevalence of diabetes mellitus (DM) also increased. Diabetic peripheral nerve (DPN) is a complication that often occurs in people with DM. This complication is the biggest cause of morbidity and mortality in patients with DM. There are several pathways that are thought to have a significant effect on the incidence of diabetic neuropathy, such as the activation of the polyol pathway from the hexosamine pathway and protein kinase C (PKC), the accumulation of advanced glycation end products (AGEs) in diabetic nerves, excessive levels of glucose and fatty acids. The last few decades of research suggest that there are transcription factors that affect the incidence of diabetic neuropathy will be discussed in this article.

Key words: Diabetic Peripheral Nerve, Neuropathic Pain, Diabetes Mellitus


 
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How to Cite this Article
Pubmed Style

Dewi PR, Widyadharma IPE, Adnyana IMO, Wihandani DM. The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review. Int J Med Rev Case Rep. 2020; 4(11): 78-80. doi:10.5455/IJMRCR.nrf2-diabetic-neuropathy

Web Style

Dewi PR, Widyadharma IPE, Adnyana IMO, Wihandani DM. The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review. https://www.mdpub.net/?mno=111665 [Access: October 13, 2024]. doi:10.5455/IJMRCR.nrf2-diabetic-neuropathy

AMA (American Medical Association) Style

Dewi PR, Widyadharma IPE, Adnyana IMO, Wihandani DM. The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review. Int J Med Rev Case Rep. 2020; 4(11): 78-80. doi:10.5455/IJMRCR.nrf2-diabetic-neuropathy


Vancouver/ICMJE Style

Dewi PR, Widyadharma IPE, Adnyana IMO, Wihandani DM. The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review. Int J Med Rev Case Rep. (2020), [cited October 13, 2024]; 4(11): 78-80. doi:10.5455/IJMRCR.nrf2-diabetic-neuropathy


Harvard Style

Dewi, P. R., Widyadharma, . I. P. E., Adnyana, . I. M. O. & Wihandani, . D. M. (2020) The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review. Int J Med Rev Case Rep, 4 (11), 78-80. doi:10.5455/IJMRCR.nrf2-diabetic-neuropathy


Turabian Style

Dewi, Putri Rossyana, I Putu Eka Widyadharma, I Made Oka Adnyana, and Desak Made Wihandani. 2020. The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review. International Journal of Medical Reviews and Case Reports, 4 (11), 78-80. doi:10.5455/IJMRCR.nrf2-diabetic-neuropathy


Chicago Style

Dewi, Putri Rossyana, I Putu Eka Widyadharma, I Made Oka Adnyana, and Desak Made Wihandani. "The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review." International Journal of Medical Reviews and Case Reports 4 (2020), 78-80. doi:10.5455/IJMRCR.nrf2-diabetic-neuropathy


MLA (The Modern Language Association) Style

Dewi, Putri Rossyana, I Putu Eka Widyadharma, I Made Oka Adnyana, and Desak Made Wihandani. "The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review." International Journal of Medical Reviews and Case Reports 4.11 (2020), 78-80. Print. doi:10.5455/IJMRCR.nrf2-diabetic-neuropathy


APA (American Psychological Association) Style

Dewi, P. R., Widyadharma, . I. P. E., Adnyana, . I. M. O. & Wihandani, . D. M. (2020) The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review. International Journal of Medical Reviews and Case Reports, 4 (11), 78-80. doi:10.5455/IJMRCR.nrf2-diabetic-neuropathy


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