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Original Article

Online Publishing Date:
03 / 10 / 2022

 


Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study

Sumitra Bhoi, Rajiv Kumar Nanda, Satarupa Dash, Sujata Panda, Chandrakant Poddar, Bimal Krushna Panda.


Abstract
Background: Migraine is a Primary Headache disorder, the exact aetiology of which till date is not established. Various neuroinflammatory conditions, cytokines, oxidative stress, neuropeptides and vasomotor changes have been hypothesized for the pathogenesis of migraine headache.
Aim and Objective: The aim of this study was to evaluate inflammatory and non-inflammatory marker levels in patients with migraine and compare with levels measured in controls.
Materials and Methods: This is a case control study of 45 cases of migraine between age group 15-50 years of either sex attending the outpatient department (OPD) of E.N.T, VIMSAR Burla between July 2019 to December 2019.After proper history and clinical evaluations, we analysed the serum level of inflammatory markers like Neutrophil-to-lymphocyte ratio (NLR), Malondialdehyde (MDA), C-Reactive Protein (CRP) and anti-inflammatory marker Adiponectin in migraine patients. We compared blood levels of these parameters of migraine patients with 45 controls attending the same OPD for ENT diseases other than migraine during the same period.
Results: The Unpaired t test between case and control groups shows significant increase in serum level of NLR,MDA and CRP in migraine patients compared to controls(P≤0.05).The case and control group did not show a significant difference in the value of adiponectin.
Conclusion: This study indicates that oxidative stress marker(MDA) and inflammatory markers like NLR and CRP may be potential risk factor for migraine. So, early prediction of inflammatory markers might be beneficial in management of migraine patients.

Key words: Migraine, Inflammatory markers, MDA, CRP, NLR


 
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How to Cite this Article
Pubmed Style

Bhoi S, Nanda RK, Dash S, Panda S, Poddar C, Panda BK. Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study. Int J Med Rev Case Rep. 2022; 6(15): 33-36. doi:10.5455/IJMRCR.172-1649748504

Web Style

Bhoi S, Nanda RK, Dash S, Panda S, Poddar C, Panda BK. Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study. https://www.mdpub.net/?mno=11602 [Access: April 05, 2024]. doi:10.5455/IJMRCR.172-1649748504

AMA (American Medical Association) Style

Bhoi S, Nanda RK, Dash S, Panda S, Poddar C, Panda BK. Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study. Int J Med Rev Case Rep. 2022; 6(15): 33-36. doi:10.5455/IJMRCR.172-1649748504


Vancouver/ICMJE Style

Bhoi S, Nanda RK, Dash S, Panda S, Poddar C, Panda BK. Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study. Int J Med Rev Case Rep. (2022), [cited April 05, 2024]; 6(15): 33-36. doi:10.5455/IJMRCR.172-1649748504


Harvard Style

Bhoi, S., Nanda, . R. K., Dash, . S., Panda, . S., Poddar, . C. & Panda, . B. K. (2022) Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study. Int J Med Rev Case Rep, 6 (15), 33-36. doi:10.5455/IJMRCR.172-1649748504


Turabian Style

Bhoi, Sumitra, Rajiv Kumar Nanda, Satarupa Dash, Sujata Panda, Chandrakant Poddar, and Bimal Krushna Panda. 2022. Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study. International Journal of Medical Reviews and Case Reports, 6 (15), 33-36. doi:10.5455/IJMRCR.172-1649748504


Chicago Style

Bhoi, Sumitra, Rajiv Kumar Nanda, Satarupa Dash, Sujata Panda, Chandrakant Poddar, and Bimal Krushna Panda. "Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study." International Journal of Medical Reviews and Case Reports 6 (2022), 33-36. doi:10.5455/IJMRCR.172-1649748504


MLA (The Modern Language Association) Style

Bhoi, Sumitra, Rajiv Kumar Nanda, Satarupa Dash, Sujata Panda, Chandrakant Poddar, and Bimal Krushna Panda. "Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study." International Journal of Medical Reviews and Case Reports 6.15 (2022), 33-36. Print. doi:10.5455/IJMRCR.172-1649748504


APA (American Psychological Association) Style

Bhoi, S., Nanda, . R. K., Dash, . S., Panda, . S., Poddar, . C. & Panda, . B. K. (2022) Status of Inflammatory and Anti-inflammatory parameters in Migraine: A Case-control Study. International Journal of Medical Reviews and Case Reports, 6 (15), 33-36. doi:10.5455/IJMRCR.172-1649748504


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