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Original Research
Online Published: 18 Dec 2022
 


Interleukin-6 and C-reactive protein as indicators of late-life cognitive decline in dementia

Ravi Kant, Shashi Kala Kumari, Nibha, Jayendra Kumar.


Abstract
Background: Patients with dementia have higher levels of peripheral inflammatory markers. We investigated whether midlife levels of interleukin-6 (IL-6) and C-reactive protein (CRP) predicted concurrently evaluated intelligence and eventual cognitive impairment in order to determine their causal function.
Method: In the cohort study, the mean values of IL-6 and CRP were measured in 100 individuals taking irregular supplements of vitamins (27.8% of whom were women) between Oct 2019 and May 2020 and June 2020 and Oct 2020. These values were then divided into tertiles to examine a 1-year decline in the mean (mean = 1, SD = 2) standardised scores of verbal fluency, memory, and reasoning. Logistic regression was used to model declines greater than 2 points. For the baseline age, sex, and education, as well as for subsequent analyses, adjustments were made to the analyses.
Result: In cross-sectional research, participants with high IL-6 levels had poorer reasoning scores (0.08 SD; 95% [CI] 20.13, 20.02). In a retrospective study, participants with high IL-6 had a 1-year reduction in reasoning that was larger (p-value = 0.02) than that of those with low IL-6 (20.28; 90% CI 20.30, 20.26) (20.34; 90% CI 20.36, 20.32). In none of the tests, CRP was connected to deterioration.
Conclusion: The overall cross-sectional and long term impacts across the 1-year observation time approximated to an age effect of 2.5 months; elevated IL-6 but not CRP in midlife indicates cognitive deterioration.

Key words: Interleukin-6, C-reactive protein, Dementia, cognitive impairment


 
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How to Cite this Article
Pubmed Style

Kant R, Kumari SK, Nibha , Kumar J. Interleukin-6 and C-reactive protein as indicators of late-life cognitive decline in dementia. Int J Med Rev Case Rep. 2022; 6(21): 31-35. doi:10.5455/IJMRCR.172-1669482402

Web Style

Kant R, Kumari SK, Nibha , Kumar J. Interleukin-6 and C-reactive protein as indicators of late-life cognitive decline in dementia. https://www.mdpub.net/?mno=132906 [Access: April 02, 2025]. doi:10.5455/IJMRCR.172-1669482402

AMA (American Medical Association) Style

Kant R, Kumari SK, Nibha , Kumar J. Interleukin-6 and C-reactive protein as indicators of late-life cognitive decline in dementia. Int J Med Rev Case Rep. 2022; 6(21): 31-35. doi:10.5455/IJMRCR.172-1669482402


Vancouver/ICMJE Style

Kant R, Kumari SK, Nibha , Kumar J. Interleukin-6 and C-reactive protein as indicators of late-life cognitive decline in dementia. Int J Med Rev Case Rep. (2022), [cited April 02, 2025]; 6(21): 31-35. doi:10.5455/IJMRCR.172-1669482402


Harvard Style

Kant, R., Kumari, . S. K., Nibha, . & Kumar, . J. (2022) Interleukin-6 and C-reactive protein as indicators of late-life cognitive decline in dementia. Int J Med Rev Case Rep, 6 (21), 31-35. doi:10.5455/IJMRCR.172-1669482402


Turabian Style

Kant, Ravi, Shashi Kala Kumari, Nibha, and Jayendra Kumar. 2022. Interleukin-6 and C-reactive protein as indicators of late-life cognitive decline in dementia. International Journal of Medical Reviews and Case Reports, 6 (21), 31-35. doi:10.5455/IJMRCR.172-1669482402


Chicago Style

Kant, Ravi, Shashi Kala Kumari, Nibha, and Jayendra Kumar. "Interleukin-6 and C-reactive protein as indicators of late-life cognitive decline in dementia." International Journal of Medical Reviews and Case Reports 6 (2022), 31-35. doi:10.5455/IJMRCR.172-1669482402


MLA (The Modern Language Association) Style

Kant, Ravi, Shashi Kala Kumari, Nibha, and Jayendra Kumar. "Interleukin-6 and C-reactive protein as indicators of late-life cognitive decline in dementia." International Journal of Medical Reviews and Case Reports 6.21 (2022), 31-35. Print. doi:10.5455/IJMRCR.172-1669482402


APA (American Psychological Association) Style

Kant, R., Kumari, . S. K., Nibha, . & Kumar, . J. (2022) Interleukin-6 and C-reactive protein as indicators of late-life cognitive decline in dementia. International Journal of Medical Reviews and Case Reports, 6 (21), 31-35. doi:10.5455/IJMRCR.172-1669482402


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