Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy

Denny Moniaga; Syakib Bakri; Haerani Rasyid; Tutik Harjiyanti; Hasyim Kasim; Sahyudin Saleh; Muhammad Ilyas; Arifin Seweng

doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

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Original Research
Online Published: 02 Feb 2019

Int J Med Rev Case Rep. 2019; 3(1): 1-4

doi: 10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy

Denny Moniaga, Syakib Bakri, Haerani Rasyid, Tutik Harjiyanti, Hasyim Kasim, Sahyudin Saleh, Muhammad Ilyas, Arifin Seweng.

Abstract
Background: Acute kidney injury in malignant subjects can be caused by the process of the malignant itself or its therapy, in this case chemotherapy. Neutrophil Gelatinase Associated Lipocalin detects acute renal injury earlier than creatinine. This study measure the dynamics of Neutrophil Gelatinase Associated Lipocalin serum in malignant subjects treated with chemotherapy.
Method: Analytical research with cohort design. The research subjects were subjects aged > 18 years treated with chemotherapy at Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Serum level of Neutrophil Gelatinase Associated Lipocalin measured before and 24 hours after chemotherapy.
Results: Post-chemotherapy Neutrophil Gelatinase Associated Lipocalin serum level was significantly higher than pre-chemotherapy (280,330 ng / ml vs. 204,453 ng / ml, p <0,001). The increased percentage of Neutrophil Gelatinase Associated Lipocalin serum level was significantly higher in subjects with serum creatinine level > 1.3 mg / dl compared to subjects with serum creatinine level < 1.3 mg / dl (185% vs 52%, p <0, 05). The increased percentage of Neutrophil Gelatinase Associated Lipocalin serum level was found to be higher in subjects with diabetes and / or hypertension than those without diabetes and / or hypertension (160% vs 48%, p <0.05).
Discussion: This study found overall increased of Neutrophil Gelatinase Associated Lipocalin serum level in malignant patients 24 hours after chemotherapy, especially in patients with serum creatinine > 1.3 mg/dl and with diabetes and/or hypertension. Possible explanation is previous kidney injury, hypertension, and diabetes melitus makes kidney vulnerable to nephrotoxic substances.

Key words: Neutrophil Gelatinase Associated Lipocalin, acute kidney injury, malignancy, chemotherapy

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Pubmed Style

Moniaga D, Bakri S, Rasyid H, Harjiyanti T, Kasim H, Saleh S, Ilyas M, Seweng A. Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. Int J Med Rev Case Rep. 2019; 3(1): 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

Web Style

Moniaga D, Bakri S, Rasyid H, Harjiyanti T, Kasim H, Saleh S, Ilyas M, Seweng A. Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. https://www.mdpub.net/?mno=19296 [Access: April 02, 2025]. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

AMA (American Medical Association) Style

Moniaga D, Bakri S, Rasyid H, Harjiyanti T, Kasim H, Saleh S, Ilyas M, Seweng A. Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. Int J Med Rev Case Rep. 2019; 3(1): 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

Vancouver/ICMJE Style

Moniaga D, Bakri S, Rasyid H, Harjiyanti T, Kasim H, Saleh S, Ilyas M, Seweng A. Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. Int J Med Rev Case Rep. (2019), [cited April 02, 2025]; 3(1): 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

Harvard Style

Moniaga, D., Bakri, . S., Rasyid, . H., Harjiyanti, . T., Kasim, . H., Saleh, . S., Ilyas, . M. & Seweng, . A. (2019) Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. Int J Med Rev Case Rep, 3 (1), 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

Turabian Style

Moniaga, Denny, Syakib Bakri, Haerani Rasyid, Tutik Harjiyanti, Hasyim Kasim, Sahyudin Saleh, Muhammad Ilyas, and Arifin Seweng. 2019. Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. International Journal of Medical Reviews and Case Reports, 3 (1), 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

Chicago Style

Moniaga, Denny, Syakib Bakri, Haerani Rasyid, Tutik Harjiyanti, Hasyim Kasim, Sahyudin Saleh, Muhammad Ilyas, and Arifin Seweng. "Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy." International Journal of Medical Reviews and Case Reports 3 (2019), 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

MLA (The Modern Language Association) Style

Moniaga, Denny, Syakib Bakri, Haerani Rasyid, Tutik Harjiyanti, Hasyim Kasim, Sahyudin Saleh, Muhammad Ilyas, and Arifin Seweng. "Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy." International Journal of Medical Reviews and Case Reports 3.1 (2019), 1-4. Print. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

APA (American Psychological Association) Style

Moniaga, D., Bakri, . S., Rasyid, . H., Harjiyanti, . T., Kasim, . H., Saleh, . S., Ilyas, . M. & Seweng, . A. (2019) Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy. International Journal of Medical Reviews and Case Reports, 3 (1), 1-4. doi:10.5455/IJMRCR.neutrophil-gelatinase-associated-lipocalin-serum-malignancy

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