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Original Research
Online Published: 16 Dec 2020
 


The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy

Ramon Satya Pradhana, Hexanto Muhartomo, M. I. Widiastuti, Aris Catur Bintoro, Endang Kustiowati, Jimmy Eko Budi Hartono.


Abstract
Background: Breast cancer is the most common malignancy in women. Chemotherapy is the main modality for treating breast cancer which affect the cognitive function. Chemotherapy increases the levels of cytokines, damage genetic material, or damage the brain’s grey matter causing cognitive deficits and neurotoxicity.
Objective: To determine the incidence of cognitive impairment before the first injection and after the third injection with an interval of 3 weeks in breast cancer patients receiving chemotherapy and hormonal therapy.
Methods: This was an analytical observational study with a prospective cohort design of postoperative breast cancer patients receiving chemotherapy who met the inclusion and exclusion criteria. Cognitive function tests were carried out using the Moca-Ina questionnaire. Data analysis included descriptive statistics, Mann Whitney test, and Spearman's bivariate correlation test. The results were significant if the p value <0.05.
Results: A total of 40 breast cancer patients were included in this study. Cognitive impairment increased after the third injection of chemotherapy in the injection chemotherapy group compared to the hormonal therapy group. There was a significant difference between pre-chemotherapy and post-third injection of breast cancer patients who received chemotherapy compared to patients who received hormonal therapy (p=0.005). There was a correlation between cognitive impairment scores and neuropathic pain before (p=0.175; rho= -0.219) and after the third chemotherapy (p=0.017; rho= -0.377).
Conclusion: Cognitive impairment increased after the third injection of chemotherapy. There was a significant difference between pre-post the third chemotherapy. There was also a correlation between cognitive impairment scores and neuropathic pain of breast cancer patients who received chemotherapy.

Key words: Chemotherapy, Cognitive Function Impairment, Neuropathic Pain


 
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How to Cite this Article
Pubmed Style

Pradhana RS, Muhartomo H, Widiastuti MI, Bintoro AC, Kustiowati E, Hartono JEB. The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. Int J Med Rev Case Rep. 2020; 4(11): 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer

Web Style

Pradhana RS, Muhartomo H, Widiastuti MI, Bintoro AC, Kustiowati E, Hartono JEB. The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. https://www.mdpub.net/?mno=20589 [Access: October 13, 2024]. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer

AMA (American Medical Association) Style

Pradhana RS, Muhartomo H, Widiastuti MI, Bintoro AC, Kustiowati E, Hartono JEB. The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. Int J Med Rev Case Rep. 2020; 4(11): 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


Vancouver/ICMJE Style

Pradhana RS, Muhartomo H, Widiastuti MI, Bintoro AC, Kustiowati E, Hartono JEB. The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. Int J Med Rev Case Rep. (2020), [cited October 13, 2024]; 4(11): 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


Harvard Style

Pradhana, R. S., Muhartomo, . H., Widiastuti, . M. I., Bintoro, . A. C., Kustiowati, . E. & Hartono, . J. E. B. (2020) The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. Int J Med Rev Case Rep, 4 (11), 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


Turabian Style

Pradhana, Ramon Satya, Hexanto Muhartomo, M. I. Widiastuti, Aris Catur Bintoro, Endang Kustiowati, and Jimmy Eko Budi Hartono. 2020. The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. International Journal of Medical Reviews and Case Reports, 4 (11), 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


Chicago Style

Pradhana, Ramon Satya, Hexanto Muhartomo, M. I. Widiastuti, Aris Catur Bintoro, Endang Kustiowati, and Jimmy Eko Budi Hartono. "The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy." International Journal of Medical Reviews and Case Reports 4 (2020), 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


MLA (The Modern Language Association) Style

Pradhana, Ramon Satya, Hexanto Muhartomo, M. I. Widiastuti, Aris Catur Bintoro, Endang Kustiowati, and Jimmy Eko Budi Hartono. "The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy." International Journal of Medical Reviews and Case Reports 4.11 (2020), 122-126. Print. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


APA (American Psychological Association) Style

Pradhana, R. S., Muhartomo, . H., Widiastuti, . M. I., Bintoro, . A. C., Kustiowati, . E. & Hartono, . J. E. B. (2020) The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. International Journal of Medical Reviews and Case Reports, 4 (11), 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


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