Auer rods in mature neutrophils in a case of acute promyelocytic leukemia

Selin  Kucukyurt; Sule Mine  Bakanay; Aydan Kilicarslan; Sema Akinci; Mehmet Gunduz; İmdat Dilek

doi:10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

2023, Vol: 7, Issue: 11

7 / 11Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Copyright Transfer Form

« Previous Article

Case Report
Online Published: 16 Feb 2019

Int J Med Rev Case Rep. 2019; 3(6): 343-345

doi: 10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

Auer rods in mature neutrophils in a case of acute promyelocytic leukemia

Selin Kucukyurt, Sule Mine Bakanay, Aydan Kilicarslan, Sema Akinci, Mehmet Gunduz, İmdat Dilek.

Cited By: 1

Abstract
Acute promyelocytic leukemia is characterized by the presence of atypical promyelocytes in bone marrow and peripheral blood. Neoplastic promyelocytes, which often have Auer rods, are most commonly seen in early myeloid precursors in certain subtypes of myeloid leukemia.
A 63-year-old male patient,was admitted to our clinic with the complaints of malaise and weight loss for several months, presented with leucopenia and mild anemia. There were no findings of organomegaly, lymphadenopathy and bleeding diathesis and no evidence of infection. Bone marrow aspiration and biopsy which was performed with the preliminary diagnosis of myelodysplastic syndrome revealed a slightly increased Myeloid/Erythroid ratio, distinct maturation arrest in the cells of myeloid lineage 15-20% of which have nucleocytoplasmic asynchrony, course cytoplasmic granules and Auer rods. Auer rods were also present in the cytoplasm of mature neutrophils. Additionally, megakaryocytes were also dysplastic. The immunohistochemical staining was positive for CD117 in 10% of the cells and there was no staining for CD34. The diagnosis was obscure until the fluorescein in situ hybridization results which was positive for PML-RARa fusion t(15;17) (q24.1;q21.2) was received. The patient was eventually diagnosed with acute promyelocytic leukemia.
This unusual case of APL was characterized with rarity of atypical promyelocytes in the bone marrow, distinct dysplasia in the myeloid and megakaryocytic lineages and silent clinical course without coagulopathy which caused delay in diagnosis, and well response to treatment.

Key words: acute promyelocytic leukemia, auer rods, mature neutrophils

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Selin Kucukyurt Articles by Sule Mine Bakanay Articles by Aydan Kilicarslan Articles by Sema Akinci Articles by Mehmet Gunduz Articles by İmdat Dilek
	on Google
	on Google Scholar

This Article Cited By the following articles

Bundles of Auer rods in mature neutrophils in a pediatric acute myeloid leukemia patient with inv(16)(p13.1q22) International Journal of Laboratory Hematology 2020; (): .	1

How to Cite this Article

Pubmed Style

Kucukyurt S, Bakanay SM, Kilicarslan A, Akinci S, Gunduz M, Dilek �, . Auer rods in mature neutrophils in a case of acute promyelocytic leukemia. Int J Med Rev Case Rep. 2019; 3(6): 343-345. doi:10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

Web Style

Kucukyurt S, Bakanay SM, Kilicarslan A, Akinci S, Gunduz M, Dilek �, . Auer rods in mature neutrophils in a case of acute promyelocytic leukemia. https://www.mdpub.net/?mno=24705 [Access: October 13, 2024]. doi:10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

AMA (American Medical Association) Style

Kucukyurt S, Bakanay SM, Kilicarslan A, Akinci S, Gunduz M, Dilek �, . Auer rods in mature neutrophils in a case of acute promyelocytic leukemia. Int J Med Rev Case Rep. 2019; 3(6): 343-345. doi:10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

Vancouver/ICMJE Style

Kucukyurt S, Bakanay SM, Kilicarslan A, Akinci S, Gunduz M, Dilek �, . Auer rods in mature neutrophils in a case of acute promyelocytic leukemia. Int J Med Rev Case Rep. (2019), [cited October 13, 2024]; 3(6): 343-345. doi:10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

Harvard Style

Kucukyurt, S. . ., Bakanay, S. M. . ., Kilicarslan, A., Akinci, S., Gunduz, M., Dilek, �. & (2019) Auer rods in mature neutrophils in a case of acute promyelocytic leukemia. Int J Med Rev Case Rep, 3 (6), 343-345. doi:10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

Turabian Style

Kucukyurt, Selin , Sule Mine Bakanay, Aydan Kilicarslan, Sema Akinci, Mehmet Gunduz, İmdat Dilek, and . 2019. Auer rods in mature neutrophils in a case of acute promyelocytic leukemia. International Journal of Medical Reviews and Case Reports, 3 (6), 343-345. doi:10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

Chicago Style

Kucukyurt, Selin , Sule Mine Bakanay, Aydan Kilicarslan, Sema Akinci, Mehmet Gunduz, İmdat Dilek, and . "Auer rods in mature neutrophils in a case of acute promyelocytic leukemia." International Journal of Medical Reviews and Case Reports 3 (2019), 343-345. doi:10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

MLA (The Modern Language Association) Style

Kucukyurt, Selin , Sule Mine Bakanay, Aydan Kilicarslan, Sema Akinci, Mehmet Gunduz, İmdat Dilek, and . "Auer rods in mature neutrophils in a case of acute promyelocytic leukemia." International Journal of Medical Reviews and Case Reports 3.6 (2019), 343-345. Print. doi:10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

APA (American Psychological Association) Style

Kucukyurt, S. . ., Bakanay, S. M. . ., Kilicarslan, A., Akinci, S., Gunduz, M., Dilek, �. & (2019) Auer rods in mature neutrophils in a case of acute promyelocytic leukemia. International Journal of Medical Reviews and Case Reports, 3 (6), 343-345. doi:10.5455/IJMRCR.AUER-RODS-IN-MATURE-NEUTROPHILS

About International Journal of Medical Reviews and Case Reports

International Journal of Medical Reviews and Case Reports (Int J Med Rev Case Rep)ISSN: 2534-9821The International Journal of Medical Reviews and Ca ... Read more.

For best results, please use Internet Explorer or Google Chrome.

Contact Information

Any correspondence, queries or additional requests for information on the manuscript submission process should be sent to the International Journal of Medical Reviews and Case Reports editorial office as follows:

Bulgarian Association of Young Surgeons (BAYS);

National Center of Public Health and Analyses (NCPHA), floor 2, office № 31, Sofia 1431, Bulgaria.

inkov@journalmedica.com

Financial department is managed by International Sci Ink Press.

It is a company registered in Bulgaria with registered no. 205414288 and registered address at 57 Antim I str., Vazrazhdane, Sofia, 1303, Bulgaria.

Tel: +359883427500

About International Journal of Medical Reviews and Case Reports

Contact Information

How to cite this article